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A previous study found that Extraversion and Conscientiousness were associated with increased and decreased expression of a pre-specified set of pro-inflammatory indicator genes. The present study aimed to replicate these findings in a sample of adults from the Refresher Cohort of the Study of Midlife in the United States (MIDUS). Analysis of gene expression composite scores and generalized linear models that took into account the heterogeneity and non-independence of RNA expression across different genes found no significant associations between the pro-inflammatory indicator gene set and the Big Five domains of personality. In addition, there was no significant association between a pre-specified antiviral indicator gene set and the Big Five domains. These findings suggest that relations between Big Five personality and expression of these two immune response indicator gene sets do not consistently appear across samples and may be context-dependent in ways that remain to be elucidated.

The current study is the first to explore the prevalence of reproductive coercion among adolescent women currently or previously involved in the U.S. foster care system. Reproductive coercion (RC), a form of intimate partner violence (IPV) involving exertion of power over a partner by controlling their reproductive health and decision making, is a significant public health concern. Existing research on RC has primarily been conducted in either healthcare settings or on college campuses. Foster youth are disproportionately impacted by both adolescent pregnancy and interpersonal violence. RC may contribute to this elevated risk.

We conducted a cross-sectional survey in 2015 and 2016 of adolescent women (n=136), ages 16-24 years old, seeking services from youth-serving agencies affiliated with a child welfare system in Pennsylvania, United States. Participants completed measures assessing RC, experiences of physical and sexual violence, sexual behaviors, and pregnancy. We used multivariable logistic regressiese young women.Monitoring business cycles faces two potentially conflicting objectives accuracy and timeliness. selleck kinase inhibitor To strike a balance between the dual objectives, we develop a Bayesian sequential quickest detection method to identify turning points in real time and propose a sequential stopping time as a solution. Using four monthly indexes of real economic activity in the US, we evaluate the method's real-time ability to date the past five recessions. The proposed method identifies similar turning point dates as the National Bureau of Economic Research (NBER), with no false alarms, but on average dates peaks 4 months faster and troughs 10 months faster relative to the NBER announcement. The timeliness of our method is also notable compared to the dynamic factor Markov-switching model - the average lead time is about 5 months in dating peaks and 2 months in dating troughs.Does childrearing affect the biological functioning of parents? To address this question, we analyze cross-sectional survey and biomarker data from Vanderbilt University's Nashville Stress and Health Study, a probability sample of non-Hispanic white and black working-age adults from Davidson County, Tennessee (2011-2014; n = 1,252). Multivariable regression analyses reveal a linear dose-response relationship between the number of children living in a respondent's home and (a) increased allostatic load, and (b) decreased leukocyte telomere length. We found no differences in biological functioning between childless respondents and empty-nest parents. These findings also withstood controls for a battery of socioeconomic factors. The implications of these findings and suggestions for future research are discussed.There has been a growing interest in optical neural interfaces which is driven by the need for improvements in spatial precision, real-time monitoring, and reduced invasiveness. Here, we present unique microfabrication and packaging techniques to build implantable optoelectronics with high precision and spatial complexity. Material characterization of our hybrid polymers shows minimal in vitro degradation, greater flexibility, and lowest optical loss (4.04-4.4 dB/cm at 670 nm) among other polymers reported in prior studies. We use the developed methods to build Lawrence Livermore National Laboratory's (LLNL's) first ultra-compact, lightweight (0.38 g), scalable and minimally invasive thin-film optoelectronic neural implant that can be used for chronic studies of brain activities. The paper concludes by summarizing the progress to date and discussing future opportunities for flexible optoelectronic interfaces in next generation clinical applications.Primates are facing a global extinction crisis driven by an expanding human population, environmental degradation, the conversion of tropical forests into monocultures for industrial agriculture and cattle ranching, unsustainable resource extraction, hunting, climate change, and the threat of emerging zoonotic diseases. And, although many primate scientists have dedicated their careers to conservation, 65% of primate species are listed as Vulnerable, Endangered, or Critically Endangered, and >75% are experiencing a population decline. Projections indicate that by the end of the century, an additional 75% of the area currently occupied by wild primates will be lost to agriculture. Clearly, we are losing the battle and must change business-as-usual if we are to protect wild primates and their habitats. This article is a call to action. Primate societies and their membership need to expand their engagement in scientific advocacy and scientific activism designed to educate, inspire, organize, and mobilize global citizens to join together, lobby business leaders and politicians in both primate habitat countries and in consumer nations, boycott forest-risk products, participate in demonstrations and letter writing campaigns, and use social media to effect transformational change. We are the experts, and the more we and our professional organizations drive the public policy debate on wildlife conservation and environmental justice, the more successful we will be in protecting the world's primates from extinction. The time to act is now!