Rossikragelund0491

Electrical-to-optical signal conversion is widely employed in information technology and is implemented using on-chip optical modulators. State-of-the-art modulator technologies are incompatible with silicon manufacturing techniques inorganic nonlinear crystals such as LiNbO3 are integrated with silicon photonic chips only using complex approaches, and hybrid silicon-LiNbO3 optical modulators show either low bandwidth or high operating voltage. read more Organic perovskites are solution-processed materials readily integrated with silicon photonics; and organic molecules embedded within the perovskite scaffold allow in principle for high polarizability. However, it is found that the large molecules required for high polarizability also require an increase of the size of the perovskite cavity specifically, using the highly polarizable DR2+ (R = H, F, Cl) in the A site necessitates the exploration of new X-site options. Only by introducing BF4- as the X-site molecule is it possible to synthesize (DCl)(NH4 )(BF4 )3 , a material exhibiting a linear EO coefficient of 20 pm V-1 , which is 10 times higher than that of metal halide perovskites and is a 1.5 fold enhancement compared to reported organic perovskites. The EO response of the organic perovskite approaches that of LiNbO3 (reff ≈ 30 pm V-1 ) and highlights the promise of rationally designed organic perovskites for use in efficient EO modulators.Wolbachia is an obligate intracellular bacterial symbiont prevalent among arthropods and nematodes. To survive and reproduce, Wolbachia interacts with and modifies host subcellular structures, while sensing and responding to changes within the cellular environment. In mutualistic associations, Wolbachia may provision the host with metabolites, or help to maintain the chemical homeostasis of the host cell. Some strains can rapidly invade insect populations by manipulating host reproductive biology, while also preventing viral replication, allowing their use in vector control of arthropod-borne viruses. The Aedes albopictus-derived strain wAlbB is promising in this regard. When transinfected into the Yellow fever mosquito, Aedes aegypti, wAlbB reaches high frequencies within wild populations, and strongly inhibits viral transmission. Despite its obvious potential, much is still unknown about the molecular interactions between Wolbachia and host that enable its use in vector control. Furthermore, most Wolbachia transinfection research to date has focused on host effects. In the current study, we used a cell line model to explore the effect of transinfection of wAlbB from Ae. albopictus to Ae. aegypti. Using RNA sequencing, we show that several genes associated with host-symbiont interactions were downregulated by transinfection, with the greatest downregulation exhibited by prophage-associated genes.An accruing body of research has shown that interoception (the sensing of signals from the body's internal milieu) relies on both a direct route (afforded by the vagus nerve) and a secondary route (supported by somatosensory mechanisms). However, no study has causally tested the differential role of these pathways, let alone via direct stimulation. To bridge this gap, we tested whether multidimensional signatures of interoception are modulated by noninvasive vagus nerve stimulation (nVNS). Sixty-three participants were divided into an nVNS and a sham-stimulation group. Before and after stimulation, both groups performed a validated heartbeat detection (HBD) task including a genuinely interoceptive condition (monitoring one's own heartbeat) and a control exteroceptive condition (tracking an aurally presented heartbeat). Electroencephalographic signals were obtained during both conditions to examine modulations of the heartbeat-evoked potential (HEP). Moreover, before and after stimulation, participants were asked to complete a somatosensory heartbeat localization task. Results from the interoceptive condition revealed that, after treatment, only the nVNS group exhibited improved performance and greater HEP modulations. No behavioral differences were found for the exteroceptive control condition, which was nonetheless associated with significant HEP modulations. Finally, no between-group differences were observed regarding the localization of the heartbeat sensations or relevant cardiodynamic variables (heart rate and or heart rate variability). link2 Taken together, these results constitute unprecedented evidence that the vagus nerve plays a direct role in neurovisceral integration during interoception. This finding can constrain mechanistic models of the domain while informing a promising transdiagnostic agenda for interoceptive impairments across neuropsychiatric conditions.The emergence of 2D polarized materials, including ferromagnetic, ferrovalley, and ferroelectric materials, has demonstrated unique quantum behaviors at atomic scales. These polarization behaviors are tightly bonded to the new degrees of freedom (DOFs) for next generation information storage and processing, which have been dramatically developed in the past few years. Here, the basic 2D polarized materials system and related devices' application in spintronics, valleytronics, and electronics are reviewed. Specifically, the underlying physical mechanism accompanied with symmetry broken theory and the modulation process through heterostructure engineering are highlighted. These summarized works focusing on the 2D polarization would continue to enrich the cognition of 2D quantum system and promising practical applications.Structurally complex π-conjugated polymers hold great promise as key components in sensor and electronic devices; however, their syntheses have not been a trivial task. From a synthetic efficiency perspective, it would be more attractive to access these materials using convenient and efficient methods from simple building blocks. One such synthetic tool, multicomponent polymerization, can accommodate modularity and provide highly efficient syntheses. This feature article outlines several multicomponent polymerization strategies for the synthesis of various π-conjugated polymers, which are classified based upon how the monomers are aligned during polymerization. Additionally, the challenges and outlooks of this field are highlighted and discussed.Recent research has uncovered many complex cognitive traits and affective processes in many reptile species, such as the ability to make choices that are rewarding or pleasurable. The investigation herein was initiated after many years of anecdotal reports, and preliminary observations, that the two male Aldabran giant tortoises (Aldabrachelys gigantea), Wilbur and Little John, at Melbourne Zoo (Melbourne, Australia) would approach the fence-line of their enclosure, sometimes multiple times daily, to "solicit" interactions from zoo visitors and/or zoo staff. Following other research with Galapagos giant tortoises (Geochelone nigra), this experiment was a novel preference test with two male Aldabran giant tortoises to assess their individual preferences for three stimuli (1) human interaction (shell and neck rubs provided using hands); (2) food (highly palatable carrot pieces); and (3) an "enrichment" ball (a red "boomer ball"). The results found that Wilbur highly preferred human interaction and food over the ball; whereas Little John preferred food, and showed some initial interest in the ball, but did not approach the human on any of his 13 human interaction trials. These results reflect previous published findings, that human interaction is a preferred "enrichment," but is dependent upon a multitude of other contextual factors, and is not preferred at all times by all individuals. Individual variation may be very important to understand to have greater positive effect on the welfare-related needs of each giant tortoise housed in captivity. Further research is clearly required to enhance the welfare and well-being of many types of zoo-housed reptiles.The PI3K/AKT/mTOR signaling pathway is a critical mediator of cell functions. Activating mutations of this pathway are known to disturb normal growth and development, leading to a range of overgrowth and neurologic syndromes. We report a case of megalencephaly-polymicrogyria-pigmentary mosaicism syndrome (MPPM) in novel association with MTOR pathogenic variant c.6644C>A (p.Ser2215Tyr) and neonatal evanescent skin findings. link3 This case highlights the importance of a thorough newborn cutaneous examination, as this initial window offers a critical opportunity for potential prognostication and surveillance for neurological sequelae.

Simulation-based obstetric team training focuses on building a system that will anticipate errors, improve patient outcomes and the performance of clinical care teams. Simulation-based obstetric team training has been proposed as a tool to improve the overall outcome of obstetric health care.

To assess the effects of simulation-based obstetric team training on patient outcomes, performance of obstetric care teams in practice and educational settings, and trainees' experience.

The Cochrane Pregnancy and Childbirth Group's Trials Register, ClinicalTrials.gov and the WHO International Clinical Trials Registry Platform (ICTRP) were searched (14 April 2020), together with references checking and hand searching the available proceedings of 2 international conferences.

We included randomised controlled trials (RCTs) (including cluster-randomised trials) comparing simulation-based obstetric team training with no, or other type of training.

We used standard methodological procedures expected by Cochrane, to Particular attention should be paid to effect measurement at the level of patient outcome, taking into consideration the low incidence of adverse maternal and perinatal events.

Simulation-based obstetric team training may help to improve team performance of obstetric teams, and it might contribute to improvement of specific maternal and perinatal outcomes, compared with no training. However, high-certainty evidence is lacking due to serious risk of bias and imprecision, and the effect cannot be generalised for all outcomes. Future studies investigating simulation-based obstetric team training compared to training courses with a different instructional design should carefully consider how and when to measure outcomes. Particular attention should be paid to effect measurement at the level of patient outcome, taking into consideration the low incidence of adverse maternal and perinatal events.The use of histamine H3 receptor (H3 R) antagonists is becoming a promising therapeutic approach for epilepsy. In this paper, a series of novel nonimidazole H3 R antagonists was synthesized and screened as antiepileptic drugs. All of these prepared antagonists displayed micromolar or submicromolar H3 R antagonistic activities in the cAMP response element luciferase screening assay. Compounds 5a (IC50  = 0.11 μM), 5b (IC50  = 0.56 μM), and 5f (IC50  = 0.78 μM) displayed the most potent H3 R antagonistic activities, with considerable potency when compared with pitolisant (IC50  = 0.51 μM). In the maximal electroshock (MES)-induced seizure model, compounds 5c, 5e, and 5g showed obvious protection for the electrostimulated mice, and the protection of 5g against the MES-induced seizures was fully abrogated when mice were cotreated with R-(α)-methyl-histamine, a central nervous system-penetrant H3 R agonist, suggesting that the potential therapeutic effect of 5g was observed to work through H3 R. These results indicate that the attempt to find a new antiepileptic drug among H3 R antagonists is practicable, but it is necessary to consider the log P of the molecules to ensure penetration of the blood-brain barrier.