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Immunoreactivity for CCL28 was observed in osteoblasts and osteoclasts on bone tissue. Additionally, Ccl28 deficiency promoted osteoblast and osteoclast maturation. Moreover, CCL28 treatment decreased osteoblast and osteoclast activities but did not affect differentiation.

In summary, this study indicated that CCL28 is one of the negative regulators of bone mass by suppressing osteoblast and osteoclast activities. These results provide important insights into bone immunology and the selection of new osteoporosis treatments.

In summary, this study indicated that CCL28 is one of the negative regulators of bone mass by suppressing osteoblast and osteoclast activities. These results provide important insights into bone immunology and the selection of new osteoporosis treatments.The competition for maize and soybean between humans and livestock for food has led to an increase in the cost of livestock feeds. Therefore, this has necessitated the search for alternative non-competitive feedstuffs in order to partially replace maize and soybean in small ruminant diets. The use of cassava products as a partial replacement for maize and soybean in small ruminant diet has been investigated. Cassava is a tropical crop, and its fodder is rich in crude protein (CP), minerals and vitamins with about 85% of the CP fraction exist as true protein. Cassava by-products are also high in nutrients and could contribute significantly to the nutritional needs of sheep and goats. Specifically, cassava leaves are high in CP (25.10%) with an amino acid composition similar to soybean. Evidence also exist that ruminal degradability of cassava fodder is similar to that of maize and soybean with comparable outflow rates (75%). However, the use of cassava fodder in livestock production is limited by the presence of cyanogenic glucosides (linamarin and lotaustralin) that releases hydrogen cyanide (HCN) known to cause pathophysiological changes in the liver of sheep and goats. Importantly, several processing techniques are well known to reduce or eliminate the concentrates of cyanogenic glucosides in cassava with great success. Blood chemistry and production indices of sheep and goats fed differently processed cassava by-product-based diets have been evaluated by different authors. This review revealed that cassava root sievate meal, cassava root meal and cassava peel meal are low in CP (2.29, 3.40 and 7.05%, respectively), while cassava leaf meal is high in CP (32.43%). Feed conversion efficiency of sheep and good fed cassava leaves were 9.49 and 11.24, respectively, indicating that goats utilize cassava leaves better than sheep. It is concluded that cassava by-products are low in quality protein and should be supplemented with other rich protein sources before their use in ruminant diets.

This study was performed to investigate leg length discrepancy (LLD), overgrowth, and associated risk factors after pediatric tibial shaft fractures.

This study included 103 patients younger than 14years of age (mean age 7.1years; 75 boys, 28 girls) with unilateral tibial shaft fracture and a minimum follow-up of 24months. LLD was calculated as the difference between the lengths of the injured and uninjured limbs. Overgrowth was calculated by adding the fracture site shortening from the LLD. Risk factors were assessed in patients with LLD < 1cm and ≥ 1cm and overgrowth < 1cm and ≥ 1cm.

Casting and titanium elastic nailing (TEN) were performed on 64 and 39 patients, respectively. The mean LLD and overgrowth were 5.6 and 6.4mm, respectively. There were significant differences in sex (p = 0.018), age (p = 0.041), fibular involvement (p = 0.005), injury mechanism (p = 0.006), and treatment methods (p < 0.001) between patients with LLDs < 1cm and ≥ 1cm. There were significant differences in sex (p = 0.029), fibular involvement (p = 0.002), injury mechanism (p = 0.008), and treatment methods (p < 0.001) between patients with overgrowth < 1cm and ≥ 1cm. Sex and treatment methods were risk factors associated with LLD ≥ 1cm and overgrowth ≥ 1cm following pediatric tibial shaft fracture. The boys had a 7.4-fold higher risk of LLD ≥ 1cm and 5.4-fold higher risk of overgrowth ≥ 1cm than the girls. Patients who underwent TEN had a 4.3-fold higher risk of LLD ≥ 1cm and 4.8-fold higher risk of overgrowth ≥ 1cm than those treated by casting.

Patients undergoing TEN showed greater LLD and overgrowth than those undergoing casting, with boys showing greater LLD and overgrowth than girls. Surgeons should consider the possibility of LLD and overgrowth after pediatric tibial shaft fractures, especially when performing TEN for boys.

Level III.

Level III.

Sodium fluorescein (fluorescein) crosses a disrupted blood-brain barrier similarly to gadolinium contrast in contrast-enhancing cerebral tumors. When exposed to light with 560 nm wavelength during surgery, fluorescein emits a yellow-green fluorescent light that can be visualized through an operating microscope equipped with an appropriate emission filter. Protein Tyrosine Kinase inhibitor The distribution of the fluorescence correlates with the contrast on a gadolinium contrast-enhanced MRI.

The objective of this single-center retrospective study was to investigate if the use of fluorescein would increase the extent of resection and to examine if fluorescein guided resection influences postoperative neurological status.

During the study period from August 2014 to August 2018, 117 patients were operated for cerebral metastases. Of these, 56 operations were guided by fluorescein and 61 by traditional white light. All patients had an early postoperative MRI within 72 h after surgery.

The use of fluorescein increased the extent of resection in patients with cerebral metastases. The use of fluorescein was not associated with increased postoperative sequelae or neurological damage regardless of underlying primary cancer.

Fluorescein is a helpful supplement in the neurosurgical treatment of cerebral metastases.

Fluorescein is a helpful supplement in the neurosurgical treatment of cerebral metastases.