Potterherskind1119

Results HR, TT, PFV, and AFV persistently and significantly increased during warming and heat-retention phases of HPTT. Trastuzumab Emtansine In WT, HR and TT significantly increased during warming but decreased and plateaued during heat-retention. BP did not change significantly after either therapy; however, BA was dilated equally in both (HPTT 3.70 ± 0.57 ⇒ 4.05 ± 0.59 mm, p = .001; WT 3.63 ± 0.63 ⇒ 3.93 ± 0.61 mm, p  less then  .001).Conclusion HPTT may be equivalent to WT with respect to vasodilation response of the skin.The traditional Chinese medicine formula Jianpi-Huayu (JPHY) has been reported to be effective in the treatment of hepatocellular carcinoma (HCC). However, its underlying mechanism remains unclear. In this article, we employed an orthotopic transplantation model in nude mice to explore whether JPHY could inhibit the development of HCC by regulating miR-602, which targets the Ras association domain-containing protein 1A (RASSF1A) pathway. HCC SMMC-7721 cells were treated with JPHY to test whether the RASSF1A gene as mediated by miR-602 affected the proliferation and apoptosis of tumor cells. We subsequently detected miR-602, RASSF1A, and tumor cell apoptosis-related markers in cells and liver tumor tissues. We observed that mice treated with JPHY had smaller tumors and higher survival rates than untreated ones. Similarly, JPHY-treated SMMC-7721 cells exhibited alterations in morphology and higher cytotoxicity compared with the control group. Furthermore, we found that JPHY decreased overexpression of miR-602 and increased protein expression levels of the RASS1A gene, which in turn altered protein expression levels of tumor cell apoptosis-related genes in the cells and liver tumor tissues of drug-treated mice. These results indicated that JPHY could potentially be used to treat HCC by targeting miR-602, which targets the RASSF1A gene, which in turn plays a major role in HCC pathogenesis.OBJECTIVE 22q11.2 deletion syndrome (22q11DS) is among the strongest known genetic risk factors for schizophrenia. Previous studies have reported variable alterations in subcortical brain structures in 22q11DS. To better characterize subcortical alterations in 22q11DS, including modulating effects of clinical and genetic heterogeneity, the authors studied a large multicenter neuroimaging cohort from the ENIGMA 22q11.2 Deletion Syndrome Working Group. METHODS Subcortical structures were measured using harmonized protocols for gross volume and subcortical shape morphometry in 533 individuals with 22q11DS and 330 matched healthy control subjects (age range, 6-56 years; 49% female). RESULTS Compared with the control group, the 22q11DS group showed lower intracranial volume (ICV) and thalamus, putamen, hippocampus, and amygdala volumes and greater lateral ventricle, caudate, and accumbens volumes (Cohen's d values, -0.90 to 0.93). Shape analysis revealed complex differences in the 22q11DS group across all structuria, and other severe neuropsychiatric illnesses.Teacher support has been shown to enhance adolescent mental health. However, the effects of negative emotions and resilience in the relationship between teacher support and mental well-being in adolescents are still unknown. This study investigated (a) the mediating role of negative emotions in the relationship between teacher support and mental well-being, (b) the mediating role of resilience in the association between teacher support and mental well-being, (c) the serial mediating role of negative emotions and then resilience in the relationship between teacher support and mental well-being, and (d) the parallel mediating role of the five dimensions of resilience and the three factors of negative emotions in the relationship between teacher support and mental well-being. Participants were 1228 Chinese adolescents (age, M = 15.43 years; 53.09% male). Participants filled out questionnaires regarding teacher support, negative emotions, resilience, and mental well-being. After controlling for age and gender, wentrol, and help-seeking behavior, and decreasing depression. These findings suggest a process through which negative emotions can decrease resilience and identify the mediating effects of negative emotions (including the three dimensions of negative emotions) and resilience (including the five factors of resilience) in the relationship between teacher support and adolescent mental well-being. Copyright © 2020 Guo, Liu, Zhao and Wang.Various smart services and technologies have been developed to support older adults' well-ness, make their daily tasks easier, and enhance their overall quality of life. When people grow older, older adults inevitably experience a significant decrease in their physical, cognitive, and sensory capabilities, which makes them develop negative attitudes toward technology. In this regard, this study highlights that older adults require not only usable and practical spaces but also smart residential environments that can fulfill them emotionally. Research on smart environments for this population should consider the hedonic and experiential factors of interacting with technology, such as fun, fulfillment, play, and user engagement. This study aims to provide a comprehensive review of smart residential environments to support positive aging and pleasurable user experience in the architecture domain. For this critical review emphasizing the pleasurable smart environment, an evaluation framework was developed, consisting of four categories well-ness, independence, acceptance, and design. Through an extensive analysis of selected papers in the architecture domain, it was found that studies on the smart home tend to focus on utilitarian factors, such as usability, monitoring physical experiences, and simulating energy efficiency, and rarely mention psychological well-ness. Smart environments should be designed to not only emphasize efficiency, effectiveness, and satisfaction but also to engage older adults and provide them positive experiences. As various smart technologies continue to evolve and integrate into smart living spaces, it is important to understand older adults' cognitive and emotional aspects and make the smart environment a more comfortable place for them. Copyright © 2020 Lee and Kim.