Pihlhorn2474

75, 95% confidence interval (CI) 1.44-2.14, p<0.001) and LOS (OR 1.07, 95%CI 1.03-1.11) were independently associated with a poor functional outcome. In the mediation analysis, the NIHSS (β=0.137, p<0.001) and LOS (β=0.09, p<0.004) were significant mediators between pre-stroke frailty status and poor functional outcome.

The relationship between pre-stroke frailty status and short-term functional outcome was mediated by disease severity and LOS in older patients with acute stroke.

The relationship between pre-stroke frailty status and short-term functional outcome was mediated by disease severity and LOS in older patients with acute stroke.Dynamic membrane bioreactors mainly rely on the in-situ formed biofilms on support materials to reject fine particles in water. The development of irremovable biofilms on support materials can decrease the cleaning efficiency when removing the unwanted biofilms with low permeability by water flushing. In the present study, the initial formed biofilms on support materials at 5-day solids retention time (SRT) were removable by water flushing. After repeated cleaning with off-line water flushing during operation, however, irremovable biofilms were developed gradually inside the mesh pores and thus, rapid rising in transmembrane pressure occurred in every one to three days. At 20-day SRT, the biofilms formed on support materials with the same operation time were still removable. Therefore, both low SRT and repeated water flushing promoted the formation of irremovable biofilms on support materials. Further study found that the composition and microbial community between the irremovable and removable biofilms were significantly different, which differentiated the biofilm adhesion and removability. The irremovable biofilms had a greater faction of proteins (49.0%) and β-d-glucopyranose polysaccharides (17.8%) in extracellular polymeric substance (EPS), while the removable biofilms had a greater fraction of α-d-glucopyranose polysaccharides. After repeated cleaning with off-line water flushing during operation, Nitrospiraceae was selectively enriched in the irremovable biofilms at a relative abundance of 39.1%, which could have resulted in the particular EPS matrix that strengthened the biofilm adhesion.Tetracycline (TC), a popularly found drug pollutant, can be contaminated in food and aquatic regions and causes a severe impact on human health. In this research, a visible light active p-stannic oxide/n-copper manganate (p-SnO2/n-CuMnO2) heterojunction was synthesized and has been applied for a signal on photoelectrochemical sensing of antibiotic TC. Firstly, the n-SnO2 microrods were synthesized via a simple and efficient homogeneous precipitation method and the p-CuMnO2 nanoparticles were synthesized by a facile ultrasound-assisted hydrothermal method. The SnO2/CuMnO2 microrods p-n heterojunction was prepared through a simple impregnation method and physicochemical properties of the microrods are characterized by using X-ray diffraction (XRD), Raman, Brunauer-Emmett-Teller (BET), Fourier-transform infrared (FTIR), UV-Vis diffuse reflectance spectroscopy (UVDRS), X-ray photoelectron spectroscopy (XPS), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), and Mott-Schottky analyses. Belinostat concentration The photoelectrochemical sensing performance of SnO2/CuMnO2 microrods was 2.7 times higher than that of as-synthesized pure SnO2 microrods is due to the more visible light absorption ability and p-n heterojunction (synergy). The designed SnO2/CuMnO2/ITO sensor gives photocurrent signals for the detection of TC in the range of 0.01-1000 μM with the detection limit (LOD) of 5.6 nM. The practical applicability of the sensor was monitored in cow milk and the Taipei River water sample.In this work, we have constructed a novel graphitic carbon nitride/multiwall carbon nanotube (GCN/CNT) doped Ti/PbO2 as anode for highly effective degradation of acetaminophen (ACE) wastewater. The ACE removal efficiency of 83.2% and chemical oxygen demand removal efficiency of 76.3% are achieved under the optimal condition of temperature 25 °C, initial pH 7, current density 15 mA cm-2 and Na2SO4 concentration 6.0 g L-1. The excellent electrocatalytic activity of Ti/PbO2-GCN-CNT anode for ACE oxidation is ascribed to the effective suppression of oxygen evolution and the enhanced electron transfer after introducing GCN and CNT. Furthermore, Ti/PbO2-GCN-CNT electrode displays excellent stability and reusability. ACE degradation is accomplished by direct oxidation and indirect oxidation, and ∙OH radical plays primary role in the indirect oxidation of ACE wastewater. The intermediates of ACE degradation are detailly investigated using LC-MS analysis and a possible degradation mechanism is proposed.Multiple myeloma (MM) patients frequently present with extensive osteolytic bone lesions. However, the impact of myeloma treatment on focal lytic lesion remineralization has not been extensively studied. In this study, the effect of anti-myeloma treatment on the extent of bone remineralization was examined and potential mediators identified. Newly diagnosed MM patients enrolled in the Total Therapy 4 and 5 (TT4; n = 231, TT5; n = 64) protocols were longitudinally evaluated for changes in radiological parameters for a median of 6.1 years. Bone remineralization was defined as a sclerotic CT change within the lytic lesion and quantified as a percentage of remineralization, using the initial lesion size as a reference. Such changes were correlated to clinical and biochemical parameters, and the gene expression profile of bone marrow biopsy. Overall, remineralization occurred in 72% of patients (213/295). Of those patients that experienced remineralization, 36% (107/295) achieved at least 25% of bone remineralization. Patients with high-risk disease defined by gene expression profile signature (GEP70 ≥ 0.66) experienced significant remineralization compared to low-risk MM. Female patients were also more likely to experience bone remineralization and in a shorter median time (2.0 vs. 3.3 y). Factors such as serum alkaline phosphatase along with high levels of RUNX2 and SOX4 gene expression correlated with increasing extent of bone remineralization. This analysis demonstrated significant remineralization of lytic lesions in MM patients treated on TT clinical trials. While the underlying mechanism remains elusive these findings support the hypothesis that patient baseline bone-related factors play a fundamental role in the skeletal repair of bone lesions in MM that provide new opportunities for improving patient outcomes.