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The overall properties of light weight, high elasticity, excellent mechanical strength, and outstanding EMI shielding performance suggest that the as-prepared EPM/AgNW composites have a great potential for applications in modern electronics.Several point mutations can modulate protein structure and dynamics, leading to different natures. Tyrphostin B42 Especially in the case of amyloidogenic proteins closely related to neurodegenerative diseases, structural changes originating from point mutations can affect fibrillation kinetics. Herein, we rationally designed mutant candidates to inhibit the fibrillation process of amyloid-β with its point mutants through multistep in silico analyses. Our results showed that the designed mutants induced kinetic self-assembly suppression and reduced the toxicity of the aggregate. A multidisciplinary biophysical approach with small-angle X-ray scattering, ion mobility-mass spectrometry, mass spectrometry, and additional in silico experiments was performed to reveal the structural basis associated with the inhibition of fibril formation. The structure-based design of the mutants with suppressed self-assembly performed in this study could provide a different perspective for modulating amyloid aggregation based on the structural understanding of the intrinsically disordered proteins.We investigated the catalytic efficacy of silicotungstic acid (H4SiW12O40) polyoxometalate (POM) toward the reaction between furfural and amines that selectively yields trans-N,N-4,5-substituted-diaminocyclopenten-2-ones (trans-DACPs). H4SiW12O40 facilitates the synthesis of a library of trans-DACPs with loadings as low as 0.05 mol %, in open air, without additives, in short times and good to high isolated yields. The protocol was applied to secondary amines as well as to aromatic primary amines with pKb higher than ca. 9. The present catalytic synthetic protocol has an extended substrate scope with high yields and represents, to the best of our knowledge, the first polyoxometalate-driven paradigm as an efficient method to produce cyclopentanone frameworks under mild reaction conditions.Extreme ultraviolet (EUV)-induced radiation exposure chemistry in organotin-oxo systems, represented by the archetypal [(R-Sn)12O14(OH)6](A)2 cage, has been investigated with density functional theory. Upholding existing experimental evidence of Sn-C cleavage-dominant chemistry, computations have revealed that either electron attachment or ionization can single-handedly trigger tin-carbon bond cleavage, partially explaining the current EUV sensitivity advantage of metal oxide systems. We have revealed that tin atoms at different parts of the molecule react differently to ionization and electron attachment and have identified such selectivity as a result of local coordination chemistry instead of the macro geometry of the molecule. An ionization-deprotonation pathway has also been identified to explain the observed evolution of an anion conjugate acid upon exposure and anion mass dependence in resist sensitivity.All-inorganic CsPbI3 perovskites have great potential in tandem cells in combination with other photovoltaic devices. However, CsPbI3 perovskite solar cells (PSCs) still face a huge challenge, resulting in a low power conversion efficiency (PCE) relative to organic-inorganic PSCs. In this work, we introduced tetrabutylammonium acetate (TBAAc) as a buffer layer between the SnO2 electron-transport layer (ETL) and CsPbI3 all-inorganic perovskite film interface for the first time. TBAAc not only improved the conductivity of SnO2 ETL but also formed a 1D TBAPbI3 layer between the SnO2 ETL and the 3D CsPbI3 all-inorganic perovskite film, thereby enhancing the stability and passivating the surface defects of the CsPbI3 perovskite to fabricate high-efficiency carbon-counter electrode (CE)-based CsPbI3 solar cells. We fabricated carbon-CE-based hole-transporting layer ( HTL)-free PSCs with an FTO/SnO2/TBAAc/CsPbI3/C structure. The open-circuit voltage (Voc), short circuit current density (Jsc), PCE, and fill factor of the champion CsPbI3 PSCs simultaneously enhanced to 1.08 V, 17.48 mA/cm2, 12.79, and 67.8%, respectively. This PCE is currently one of the high efficiencies reported for the above planar-structured carbon-CE-based CsPbI3 PSCs to date. Moreover, the optimized device exhibits excellent stability, which retained over 83% of its initial PCE after 350 h. This work provides a facile way of simultaneous optimization of the SnO2 ETL and the CsPbI3 perovskite layer to fabricate stable and high-efficiency carbon-CE-based CsPbI3 PSCs.In this work, (Ag, In)-co-doped Cu2SnSe3-based compounds are prepared using a self-propagating high-temperature synthesis process. Ag2Se and as-synthesized (Ag, In)-co-doped Cu2SnSe3-based powders are mixed in a proportion according to the formula of Cu1.85Ag0.15Sn0.91In0.09Se3/x Ag2Se (x = 0, 3, 4, and 5%), which is followed by a subsequent plasma-activated sintering (PAS) to obtain consolidated composite bulks. A sandwich experiment is designed to reveal the evolution of the microstructure and phase composition of the composite samples during the PAS process. We investigate the reaction mechanism between Ag2Se and Cu2SnSe3-based matrix as well as the influence of Ag2Se on the phase composition, microstructure, and thermoelectric transport properties of the composites. Ag2Se addition is proven to be effective to improve Ag solubility in the Cu1.85Ag0.15Sn0.91In0.09Se3 matrix and introduce a CuSe secondary phase and an Ag-rich phase at grain boundaries. The electrical conductivity of Cu1.85Ag0.15Sn0.91In0.09Se3/x Ag2Se (x = 0, 3, 4, and 5%) composites decreases while the Seebeck coefficient increases with increasing Ag2Se addition, resulting in an optimized power factor. Moreover, benefiting from the collective phonon scattering at various defects induced by Ag2Se addition, the composite samples exhibit significantly suppressed lattice thermal conductivity, which reaches as low as 0.11 W m-1 K-1 at 700 K for the x = 5% sample. A peak figure-of-merit (ZT) of 1.26 at 750 K and an average ZT of 0.75 at 300-800 K are obtained for Cu1.85Ag0.15Sn0.91In0.09Se3/5% Ag2Se. This work provides an efficient way to improve average ZT values of Cu2SnSe3-based compounds for promising power generation at intermediate temperatures.Functional materials with stable and adjustable luminescence have recently become a research hotspot for their broad application prospects. Tunable luminescence can be realized by the doping of hetero-valent europium ions. High-temperature hydrogen atmosphere reduction is required in the traditional preparation of Eu2+-doped phosphors. Herein, an anoxic molten-salt medium environment was established to form oxygen vacancy defects in the reaction system and induce the self-reduction of Eu3+ ions to obtain Eu2+ ions. X-ray photoelectron spectroscopy (XPS) results confirm the existence of Eu2+ and Eu3+ ions in the samples, and the fluorescence spectrum shows that hetero-valent Eu ions can synergistically emit light effectively. Under 266 nm ultraviolet light excitation, the white light emission was successfully realized for a Ba2InTaO6Eu phosphor by different emission combinations of Eu3+ and Eu2+ ions. In addition, the Ba2InTaO6Eu phosphor exhibits adjustable luminescence from greenish-yellow to red exciting at 390-490 nm, which has superior stability in a high-temperature and high-humidity environment. Therefore, it is very promising that Ba2InTaO6Eu will be used as multi-color functional materials in many fields such as communication encryption and colorful decoration.Cesarean scar ectopic pregnancy (CSEP) is a very rare form of ectopic pregnancy in which implantation occurs at the site of the previous cesarean scar with low or absent beta-human chorionic gonadotropin (hCG) levels. It has various differential diagnoses on gross and microscopic examination. A delay in the identification and management of this condition may lead to life-threatening complications. Here, we discuss the incidence and clinicopathological features of chronic CSEP, its types, and differential diagnoses.Three cases of synchronous primary bilateral macronodular adrenal hyperplasia(PBMAH) and renal cell carcinoma (RCC) in the Department of Urology of Peking Union Medical College Hospital were retrospectively reviewed. The clinical features, imaging features, treatment methods and pathological features of these patients were analyzed. It was found that the genetic relationship between synchronous PBMAH and RCC needs further research. And RCC is easy to be misdiagnosed. We should pay high attention to imaging features to find out whether there are lesions in bilateral kidneys when we deal with bilateral adrenal lesions. Laparoscopic approach is recommended for PBMAH and RCC. Total or partial nephrectomy should be performed according the tumor size and location of the renal mass. Patients with PBMAH should be closely followed up after bilateral adrenalectomy to avoid delay in diagnosis or treatment of RCC.The clinical and pathological features and postoperative outcomes of 49 patients with diffuse low-grade glioma -related epilepsy who were admitted to the Department of Neurosurgery of the First Affiliated Hospital of Fujian Medical University from January 2015 to December 2018 were analyzed. After 1-year follow-up, 33 patients (67.3%) in the good prognosis group and 16 patients (32.7%) in the poor prognosis group were enrolled. Multivariate logistic regression analysis indicatedthat subtotal tumor resection (OR=5.56, 95%CI1.21-25.44,P=0.027) and no postoperative radiotherapy (OR=9.24, 95%CI2.05-41.75, P=0.004) were the risk factors for poor prognosis of postoperative epilepsy. Therefore, for patients with diffuse low-grade glioma-related epilepsy, total tumor resection and postoperative radiotherapy are beneficial to the control of epilepsy.This study investigated the disease spectrum in 209 patients with different types of scalp scaly cutaneous diseases. The quality of life of patients with the diseases were also analyzed. We found that seborrheic dermatitis (52.6%), dandruff (14.4%), eczema (17.7%) and psoriasis (15.3%) are common scalp scaly diseases. Eczema and psoriasis can be restricted to the scalp. The four diseases occur frequently in 20-40 years. Compared with patients with seborrheic dermatitis, those with dandruff were statistically different in terms of gender (P=0.004), occupation (P=0.010), drinking (P=0.007) and distressing factors (P=0.016). The average quality of life scores for scalp seborrheic dermatitis, dandruff, eczema and psoriasis were 3.00(1.00, 6.00),2.00(1.00, 5.25),4.00(1.00, 8.50)and 3.00(1.25, 6.75), respectively (P=0.42). The difference between the quality of the four diseases were not statistically significant. The diseases reduced patients' quality of life.Objective To assess the immunogenicity and safety of a booster vaccination with an inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. Methods The phase Ⅱ trial of an inactivated SARS-CoV-2 vaccine was conducted by Jiangsu Provincial Center for Disease Control and Prevention (CDC) since October 2020. The subjects were healthy adults aged 18-59 years, excluding pregnant, and not breastfeeding women. The primary vaccination schedule groups were 0-14 d 5 μg, 0-14 d 10 μg, 0-28 d 5 μg and 0-28 d 10 μg, respectively. And 50 participants in each group, a total of 200, who have received 2-doses primary vaccination were selected in ascending order of the study number and vaccinated with a booster dose (same dosage as primary vaccination) at the 6th months after post the primary vaccination (30-day window period). Blood samples were collected before and after boosting and tested for the geometric mean titers (GMT) and seroconversion of live virus neutralizing antibody, pseudovirus neutralizing antibody and receptor-binding-domain (RBD) IgG antibody.