Paynemullins3807

In order to improve interfacial adhesion between basalt fibers (BF) and glass ionomer cement (GIC) matrix, a silane named 3-aminopropyltriethoxysilane (APS) was used to modify the surface of BF. APS treated BF (APS-BF) was characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM). The influence of APS concentration on mechanical properties of APS-BF reinforced GIC (APS-BF-GIC) was investigated, and water aging resistance of optimum APS-BF-GIC was also studied. selleck kinase inhibitor The results showed that 5 wt% of APS was the optimum concentration for BF modification, for 5%APS-BF-GIC had the best comprehensive mechanical properties in all of APS-BF-GICs. Though 5%APS-BF-GIC had higher water sorption than BF-GIC and GIC, it still had higher flexural strength and exhibited better water-aging resistance.The purpose of this study was to investigate the effect of load-induced local mechanical strain on bone cell activity of peri-implant bone in mice. Titanium implants were placed in the maxillae of 13-week-old male C57BL/6J mice and subjected to intermittent 0.15 N, 0.3 N, or 0.6 N loads for 30 min/day for 6 days. The animals were sacrificed 2 days after the final loading. Unloaded mice were used as controls. An animal-specific three-dimensional finite element model was constructed based on morphological data retrieved from in vivo microfocus computed tomography for each mouse to calculate the mechanical strain distribution. Strain distribution images were overlaid on corresponding histological images of the same site in the same animal. The buccal cervical region of the peri-implant bone was predetermined as the region of interest (ROI). Each ROI was divided by four strain intensity levels 0-20 με, 20-60 με, 60-100 με, and ≥100 με, and the bone histomorphometric parameters were analyzed by the total area of each strain range for all loaded samples. The distance between the calcified front and calcein labeling as a parameter representing the mineral apposition rate was significantly greater in the areas with strain intensity ≥100 με than in the area with strain intensity less then 100 με, suggesting that the bone formation activity of osteoblasts was locally enhanced by a higher mechanical strain. However, the shrunken osteocytes and the empty osteocyte lacunae were significantly lower in the highest strain area, suggesting that osteoclastogenesis was more retarded in higher strain areas than in lower strain areas. The histomorphometric parameters were not affected geometrically in the unloaded animals, suggesting that the load-induced mechanical strain caused differences in the histomorphometric parameters. Our findings support the hypothesis that bone cell activity related to bone resorption and formation is local strain-dependent on implant loading.Dental resin composites (DRCs) with 15 wt% (EC-15%) and 20 wt% (EC-20%) synthesized branched silicone methacrylate (BSM) in resin matrix have showed anti-adhesion effect against Streptococcus mutans. With the aim to evaluate the BSM containing DRCs further, water sorption (WS), solubility (SL), mechanical properties before and after water immersion, anti-adhesion effect against dual-species, bonding strength to adhesive treated dentin, and cytotoxicity of BSM containing DRCs were investigated. DRC without BSM was used as control. The WS and SL were obtained until the mass variation of composite in distilled water kept stable. Three-point bending test was used to evaluate flexural strength (FS) and modulus (FM) of composite before and after water immersion. Mixture of Streptococcus mutans and Lactobacillus acidophilus was used to study the anti-adhesion effect against dual-species. Bonding strength of composite to adhesive treated dentin was measured through macro-shear test. Extract of composite was used to evaluate its cytotoxicity effect on L-929 mouse fibroblasts, and cell viability was obtained by MTT assay. The results showed that EC-15% and EC-20% had similar WS and SL as control (p 0.05); More bacteria were recovered from the surface of control than those from the surface of EC-15% and EC-20% (p less then 0.05); Extract of EC-15% was less cytotoxic (higher cell viability) than those EC-20% and control (p less then 0.05). All of results revealed that incorporation of 15 wt% or 20 wt% BSM in resin matrix could endow DRC with inhibition effect on dual-species biofilm formation without impairing physiochemical properties, bonding strength to adhesive treated dentin, and cytotoxicity of DRC.Fatigue fracture is a major threaten to implantable medical coils such as platinum-iridium (Pt-Ir) coils used in deep brain stimulation leads. The fractography under bending and torsion fatigue was studied in comparison with mechanical analysis to grasp load-specific fatigue characteristics and understand the mechanisms. Mechanical analysis of the coil under bending and torsion was conducted with both analytical and numerical methods. Pt-Ir coils were experimentally fatigued at roughly paralleled bending and torsional load levels. The fatigue life was recorded and the fracture morphology was observed and analyzed. It is revealed that the helical structure of the coil turns bending and torsion loads into different locally distributed stresses, which mainly determine the fatigue behaviors. Features of fracture morphology, such as ratchet mark and fatigue striation, are identifiable to differentiate load types and stress levels. Both bending and torsion may play important roles in fatigue fractures of the coil. The study proposes an effective approach to study load-specific fatigue characteristics of medical coils which provides fundamental knowledge for medical lead design and clinical fracture diagnosis.

Placental abruption (PA) is associated with adverse maternal and neonatal outcomes. Increasing evidence has shown an association between abruption and inflammation as well as utilization of hematological biomarkers to predict the later. We aimed to evaluate the feasibility of using neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ration (PLR) taken early in pregnancy in predicting later occurrence of PA.

A nested case control study, which compared parturient with PA (cases) to parturient without PA (controls). Parturient were matched by hospitalization date and maternal age. Demographic, clinical, and obstetrical characteristics were retrieved. Hematological indices derived from complete blood count taken during the first trimester of pregnancy, specifically NLR and PLR were retrieved and compared between the groups. Mann-Whitney and T-test were performed for not normally and normally distributed continuous variables respectively, categorical variables were analyzed using Chi-Square or Fisher Exact test as appropriate.

The study comprised of 232 patients. Of these, 131 had suffered from PA and 131 without PA. Parturient who had PA has significantly higher rates of hypertensive disorders of pregnancy, mean neutrophil, lymphocyte and platelet count did not differ between the groups. A comparison of NLR and PLR between the study groups yielded no significant differences.

NLR and PLR taken early in the course of pregnancy were not found associated with PA. Given the potentially severe consequences of PA, the biological plausibility and the readiness of these hematological markers, further investigation of this method with larger, prospective studies are needed.

NLR and PLR taken early in the course of pregnancy were not found associated with PA. Given the potentially severe consequences of PA, the biological plausibility and the readiness of these hematological markers, further investigation of this method with larger, prospective studies are needed.

In female cancer patients anticipating chemotherapy or radiation, oocyte retrieval for fertility should be performed as efficiently as possible to avoid postponing cancer treatments. Our objective was to compare clinical outcomes among female cancer patients who underwent a conventional early follicular phase-start ovarian stimulation cycle and those who underwent a random-start ovarian stimulation cycle.

A systematic review of the literature was performed in accordance with PRISMA guidelines. Medline, Embase.com, Scopus, Cochrane Library, and Clinicaltrials.gov databases were searched to identify all original research published in English through July 2020 on the topic of female cancer patients undergoing ovarian stimulation with a random or conventional start. Studies lacking a comparison group or including women who had already undergone chemotherapy at the time of ovarian stimulation were excluded. The primary author assessed all identified article titles and abstracts, and two independent reviewers a they may help facilitate fertility preservation for cancer patients.

Although random-start cycles may entail a longer duration of stimulation and use more total gonadotropins than conventional-start cycles, the absolute differences are small and likely do not significantly affect treatment costs. The similar numbers of mature oocytes retrieved, fertilization rates, and number of embryos cryopreserved in the two start-types suggest that they do not differ in any clinically important ways. Given that random-start cycles can be initiated quickly, they may help facilitate fertility preservation for cancer patients.Adenomyosis is characterized by the presence of ectopic endometrial tissue within the myometrium. Treatment options ranges from use of non-steroidal anti-inflammatory drugs and hormonal suppression for symptomatic relief, to endometrial ablation or even hysterectomy. In this paper we report the case of successful ultrasound-guided aspiration of focal adenomyosis with intracavitary alcohol instillation in a young patient with symptomatic juvenile cystic adenomyoma. This is the second report of the treatment of sclerotherapy by alcohol instillation, which may be considered as an alternative modality in treating the cases of symptomatic adenomyoma.

The exploration of male infertility is mainly based on semen analysis, but its evaluation might be affected by the operator's competence and subjectivity. This led to the development of automated semen analyzing systems. Despite continuous improvement, the precision and correlation of these automated systems with manual sperm assessment performed strictly according to WHO guidelines remains variable in the literature, and their role in daily practice is debated.

In this double blind prospective study, we compared the results provided by 2 automated systems based on different concepts (CASA and electro-optical signal) with manual sperm assessment. Sperm concentration, motility and morphology were performed simultaneously and independently by different operators, blinded to each other.

A total of 102 unselected men attending the andrology department for routine sperm analysis were included in the study. We found no significant difference between each automated method and manual assessment for all sperm parameters, except for sperm morphology assessment where the electro-optical system gave higher results and performed slightly poorer than CASA. Correlation was moderate to high between manual assessment and each automated methods for all sperm parameters, with randomly distributed differences.

Overall, these results show that both types of automated systems can be implemented in andrology laboratory for routine sperm analysis.

Overall, these results show that both types of automated systems can be implemented in andrology laboratory for routine sperm analysis.