Paulsenbrennan3038

The role of the coagulation pathway is more significant in COVID-19 but less in HUS. Excessive complement activation appears to be a determinant of severe prognosis in both diseases. Regarding COVID-19, children have a milder symptomatology than adults, but in some cases the paediatric inflammatory multisystem syndrome (PIMS) is described.In the past years, scientific research has highlighted the presence of a new cardiovascular risk factor, the implications of which have not been sufficiently studied so far. It is different from conventional risk factors because it acts independently at the endothelial level, having important proatherogenic properties. Through its action, this risk factor leads to increased oxidative stress and promotes the onset of atherosclerosis faster than other well-known risk factors so far. Asymmetric dimethylarginine (ADMA) is a methylprotein that arises from posttranslational methylation of proteins. Its importance has emerged in recent years, when the rate of cardiovascular mortality among patients with chronic kidney disease has been high. The distinctive element of this risk factor compared to other well-known ones is given by its ability to compete directly with nitric oxide synthase, being its strongest endogenous inhibitor, with strong proatherogenic attributions. Given that ADMA has tight correlations with atherogenesis and endothelial damage, its assessment should be taken into consideration for any patient who has been recently diagnosed with high blood pressure.Background and aims Identification of coronary artery disease by non-invasive means is a subject of interest for all. Myocardial strain has shown some promising results. This study intends to see if change in strain value correlates with the angiographic findings in patients with stable angina. It is also assessing whether myocardial strain can predict the presence of coronary artery disease (CAD) in stable angina patients. Method This cross-sectional study was carried out on 84 stable angina patients with no previous cardiac history and normal LV function undergoing coronary angiogram for guideline-based indication. After careful history, clinical examination and investigations, including conventional echocardiography, selected participants underwent 2-D speckle tracking echocardiography for measurement of myocardial strain by automated functional imaging. All participants underwent coronary angiogram and stenosis >70% was considered significant. Gensini score was calculated. The myocardial strain value and le angina. It is an independent predictor of significant coronary artery disease, which it can detect with good sensitivity and specificity.Objectives The present study aimed to evaluate the effect of curing time and bleaching agents on microhybrid composite resin surface microhardness. Material and method A total of 180 microhybrid composite resin disks were divided into two groups in terms of curing time 40 s, 60 s. Then, each group was divided into three subgroups control (distilled water), home bleaching (15% carbamide peroxide) and office bleaching (40% hydrogen peroxide). Surface microhardness of the samples was determined by using Vickers hardness test both at baseline and after the completion of the tests. Two-way ANOVA and Tukey HSD tests were used to analyze and compare microhardness changes between groups. Statistical significance was defined at P less then 0.05. Results Based on the two-way ANOVA, curing time, bleaching method, and cumulative effect of these two variables significantly affected composite resin microhardness (P less then 0.001). Tukey HSD tests showed that microhardness had significantly decreased in the bleaching groups, with the highest decrease when the office bleaching method was used (P less then 0.001). The samples cured for 40 s exhibited lower microhardness than those cured for 60 s and had an increased reduction in microhardness after bleaching (P less then 0.001). Conclusions Application of both bleaching methods decreased the surface hardness of microhybrid composite resin. An increase in the curing time was associated with a decrease in adverse effects of bleaching agents on microhardness.Objectives The present study aims to identify the current level of clinical and technological performance of dental prosthetic rehabilitation on implants and the possible existence of correlations between different designs and occurring complications in Romanian practice. Material and method An online questionnaire with 36 questions, grouped into five sections, has been designed using the Google Forms application. In 2019, it was approved by the Romanian Dental and Maxillofacial Prosthetic Society, and the link to the questionnaire was distributed via email to 70 members. The answers with multiple choice option were summarized in an Excel document, coded and statistically processed in the specific software (SPSS v20.0; IBM Corp). Fisher's exact test, likelihood ratio and linearby- linear association were used, and pairs of two questions were tested considering a standard statistical significance p value=0.05. Results The results show that screwed rehabilitations (80.5%) on platform switched (70.9%) bone level implant (76.4%) with multiunit (69.1%) abutments for fixed total prosthesis, and custom abutments (43.6%) for removable prosthesis are preferred in Romanian practice. selleck compound Most common problems of fixed rehabilitation on implants are related to aesthetics (65.5%) and for overdenture to unscrewing (56.4%). Resin-polymerized material in the laboratory, acrylic teeth and milled metallic structure in both arches was the preferred design for fixed restauration in both arches. Multiple statistic significant correlations (p less then 0.05) were found between the design type and complications. Conclusions Our findings outline current clinical and technological preferences in Romanian practice on prosthetic implant rehabilitations, illustrating a great need for further research and education consensus.Introduction Despite significant advances in its prevention and acute-phase treatment, stroke is still one of the leading causes of disability and death worldwide. Ischemic stroke accounts for 80 to 87% of all strokes, with 15-30% of cases being caused by extracranial carotid artery (CA) stenosis. Methods This is an observational, cross-sectional, single-center, prospective, registry-based study. The current research presents the preliminary results after analyzing the demographic features, biological data, and cardio- and cerebro-vascular risk factors of the first 74 patients included in the first "Romanian registry for cervical and cerebral arterial stenosis." Results In our group of patients, the severity of carotid artery stenosis was related to fibrinogen, total cholesterol, and triglyceride blood levels. Moreover, patients who underwent carotid artery stenosis were more prone to having peri-procedural complications if they had a low blood platelet count. Concerning the associated pathologies of patients with severe carotid atheromatosis, the risk of having lower cognitive abilities was higher in subjects with atrial fibrillation, regardless of the severity of carotid artery stenosis. Conclusions The presented study brings essential information about a population more prone to cerebral ischemic events than that of most other countries. All data obtained until this moment and which will further result from analyzing the clinical, demographic, and biological features of patients included in this registry should be used for implementing populational strategies for preventing further strokes.Objectives To evaluate sexual function in Iranian pregnant women in different trimesters. Materials and methods This cross sectional study was conducted in a women's hospital between August 2013 and August 2014. Four hundred pregnant women were asked to answer the valid and reliable Persian version of Beck depression inventory (BDI) and valid FSFI (Female sexual function index) questionnaires. Results Forty five subjects were in the first trimester of pregnancy, 170 in the second trimester and 185 in the third trimester. Except BDI and desire subscale of FSFI, all scores were significantly different between the three groups. By considering 26.55 as the cut off point for FSFI, 38 (84.4%) women in the first trimester, 138 (81.2%) in the second trimester, and 156 (84.3%) in the third trimester had sexual dysfunction. Logistic regression analysis showed that BDI was an independent predictor of sexual dysfunction among participants. link2 Conclusions As sexual life is an important aspect of marital life, physicians should pay more attention to it in pregnant women.Objectives Many countries have implemented quarantines to control the Coronavirus (COVID-19) pandemic spread. The quarantine effects on surgically-treated fractures, operated during this period (March 9th - May 4th) in two public Greek institutions, the "Venizeleion" General Hospital of Crete (VGH) and the "251" Hellenic Air Force General Hospital of Athens ("251" HAFGH) were evaluated and compared with those of the same period of 2019. Materials and methods This is a retrospective study of a prospectively collected database. Evaluated data included gender, age, and trauma mechanism. Outcomes A total of 103 patients who had suffered fractures were surgically treated in both institutions during the quarantine period of 2020 compared to 179 during the same period of 2019, showing a reduction of 43% in surgical cases. link3 The mean age of patients treated in 2020 was 72.2 (SD=19.9), as compared to 65.3 (SD=21.5; p-value=0.008) in 2019. There were 70 (68%) elderly patients (>65 years) in 2020 and 103 (57.6%) in 2019. Of all treated fractures, 31% were caused by high energy mechanisms during the explored period of 2020, as compared to 45% in 2019 (p-value=0.019). Conclusions This is the first study in Europe evaluating the effect of COVID-19 quarantine on surgically treated fractures. The findings showed a significant decline in surgically treated fractures, particularly high-energy fractures, along with a significantly higher mean age of patients in 2020 compared to 2019. Low-energy fractures in elderly during quarantine emphasizes the need of prevention measures to minimize their incidence, especially in a time when the health personnel and resources are engaged in the battle against COVID-19.Background Type 2 diabetes mellitus (T2DM) is an increasingly common disorder characterized by chronic hyperglycemia and marked dyslipidemia. This study evaluates the effect of vitamin D supplementation alone and in combination with glimepiride in streptozotocin-induced T2DM in rats. Materials and methods A total of 30 Wistar albino rats of either sex weighing 150-200 g were included in the study. The effect of oral administration of vitamin D was evaluated in streptozotocin-induced T2DM in rats. Blood glucose, serum insulin, serum HbA1c, and serum vitamin D were evaluated. Results D treatment has significantly improved hyperglycemia, hyperinsulinemia, and insulin sensitivity compared with the non-treated diabetic rats. Oral administration of vitamin D in streptozotocin-induced T2DM reduced blood sugar levels, increased insulin levels (more prominently when administered along with glimepiride) and decreased HbA1c levels (p less then 0.005). Conclusions Administration of vitamin D can improve hyperglycemia and hyperinsulinemia in streptozotocin-induced T2DM in rats.