Ottesenenevoldsen6043

During the 2nd month of life, the rats underwent behavioural testing, and monoamine levels in brain structures were measured. It was shown that neonatal FA exposure leads to the impaired emotional response to stress and novelty and delayed acquisition of food-motivated maze task in adolescent and young adult rats. Furthermore, FA exposure induced alterations in the monoamine levels in brains of 1- and 2- month-old rats. Semax administration reduced the anxiety-like behaviour, improved learning abilities and normalized the levels of brain biogenic amines impaired by the FA exposure. The results demonstrate that early-life FA exposure in rat pups produces long-term disturbances in their anxiety-related behaviour, learning abilities, and brain monoamines content. Semax exerts a favourable effect on behaviour and biogenic amine system of rats exposed to the antidepressant. Thus, peptide Semax can prevent behavioural deficits caused by altered 5-HT levels during development.

Frailty is highly prevalent in older adults. Malnutrition is a common problem in older adults and is related to frailty.

The aim was to investigate a structural frailty model, to verify the factors which affect the frailty of older adults, and to evaluate the moderating effects of nutritional status on frailty through multi-group analysis.

Secondary analysis as a descriptive survey.

Data were prospectively collected from 1,374 older adults (age ≥ 70) from the Korean Frailty and Aging Cohort Study in 2017.

Frailty was measured by the FRAIL scale [robust (score 0), pre-frailty (score 1-2), frailty (score 3-5)], and nutritional status was evaluated by the Mini Nutritional Assessment (MNA) [well-nourished (score ≥ 24), risk of malnutrition (score 17-23.5), malnourished (score < 17)]. Other domains were evaluated with the hand grip strength test, Short Physical Performance Battery (SPPB), short form of the Geriatric Depression Scale (GDS), Mini-Mental State Examination (MMSE), and ENRICHD Social Suppo to the well-nourished group.

Depression, SPPB, age, polypharmacy, cognitive function, and female sex were found to be important factors that affect frailty. Malnourished older adults are more likely to suffer from physical impairment, lower cognitive function, and frailty. Vigorous efforts are needed to improve nutritional status in older adults, which ultimately might improve functional outcomes and frailty.

Depression, SPPB, age, polypharmacy, cognitive function, and female sex were found to be important factors that affect frailty. Malnourished older adults are more likely to suffer from physical impairment, lower cognitive function, and frailty. Vigorous efforts are needed to improve nutritional status in older adults, which ultimately might improve functional outcomes and frailty.According to the dimensional approach to psychosis, there is a continuum from low schizotypy to schizophrenia patients. The temporal aspect of sensory processing seems to be compromised across such continuum, as suggested by different studies separately investigating unisensory or multisensory domains. Most of these studies have so far focused primarily on the temporal processing of visual and auditory stimuli, either in schizotypy or schizophrenia, while leaving the tactile domain and the integration of touch with other senses mostly unexplored. Given the relevance of body-related perceptual abnormalities for psychosis proneness, we aimed at filling this gap in the literature across two studies. We asked participants with increasing levels of schizotypy (study 1) and schizophrenia patients (study 2) to perform three simultaneity judgement tasks a unimodal tactile task, a unimodal auditory task and a bimodal audio-tactile task. Each task allowed estimating a simultaneity range (SR), as a proxy of the individual tolerance to asynchronies in the tactile, auditory and audio-tactile domains, respectively. Results showed larger SRs as the level of schizotypy increases. Specifically, the linear effect of schizotypy levels on the audio-tactile task was stronger than on the auditory task, which in turn was greater than the effect on the tactile task (study 1). Differently, schizophrenia patients showed larger SRs than controls in all the three tasks (study 2). The current study is the first empirical investigation across the continuum from low schizotypy to schizophrenia of the tolerance to asynchronies in the processing of external (auditory) and body-related (tactile) inputs.Around the global construction industry, there is an emerging trend to pursue a "zero-waste" goal at the site level, but little is known about it. This paper aims to shed insights on the waste management concept of "zero waste construction site" by delineating its meaning, system boundary, assessment period, and operation strategies, which are further formulated in an analytical framework. Owing to the nascent nature of the concept, we adopted a qualitative approach including archival study, a series of semi-structured interviews, and two in-depth case studies in Shenzhen, China to sketch the analytical framework. Meanwhile, an analogy between "zero waste construction site" and "net zero building" is continuously made to fine-tune and finalize the framework. This research demonstrates that the zero-waste goal is challenging but achievable on individual construction sites. The system boundary to examine the zero-waste goal is contingent on the project scope, be it a new construction, renovation, or demolition project. The assessment period is dependent on the duration of the construction project. However, it would be too costly, if not entirely impossible, to achieve a "zero waste construction site" by treating it as a closed system. WAY-309236-A Rather, one needs to consider open, off-site strategies, e.g., engaging third-party recycling services, reusing recycled materials in subsequent projects, or trading it in to a recycled material market. The analytical framework can be utilized to scrutinize existing construction waste management practices. In the long term, the research will contribute positively to a "zero waste" society.