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Various anthropogenic and natural events over the years have gradually increased human exposure to various heavy metals. Several of these heavy metals including cadmium, mercury, nickel, chromium, and the metalloid arsenic among others, have created major public health concerns for their high level of toxicities. Identification of the general as well as the differentially affected cellular metabolic pathways will help understanding the molecular mechanism of different heavy metal-induced toxicities. In this study, we analyzed 25 paired (control vs. treated) transcriptomic datasets derived following treatment of various human cells with different heavy metals and metalloid (arsenic, cadmium, chromium, iron, mercury, nickel and vanadium) to identify the affected metabolic pathways. The effects of these metals on metabolic pathways depend not only on the metals per se, but also on the nature of the treated cells. Tissue of origin, therefore, must be considered while assessing the effects of any particular heavy metal or metalloid. Among the metals and metalloid, arsenic appears to have relatively more pleiotropic influences on cellular metabolic pathways including those known to have association with diabetes. click here Although only two stem cell derived datasets are included in the current study, effects of heavy metals on these cells appear to be different from other mature cells of similar tissue origin. This study provides useful information about different heavy metal affected pathways, which may be useful in further exploration using wet-lab based techniques.

/objective The Survey Instrument for Natural History, Aetiology and Prevalence of Patellofemoral Pain (SNAPPS) is a self-report questionnaire which is a specifically designed measurement instrument to identify patellofemoral pain. It has reported high sensitivity, specificity and test-retest reliability to discriminate between people with knee pain, with or without patellofemoral pain. SNAPPS hasn't been studied in Thailand; therefore, the aim of this study was to cross-culturally adapt the questionnaire into Thai.

This study was separated into two phases cross-cultural adaptation and test-retest reliability. The Survey Instrument for Natural History, Aetiology and Prevalence of Patellofemoral Pain was translated into Thai following the guidelines for the cross cultural adaptation of self-report measures including six steps. Thirty four knee pain patients performed the test-retest reliability of the final version of this questionnaire. They were clinically diagnosed with patellofemoral pain by a physical n in young Thai patients.

The Thai version of the Survey Instrument for Natural History, Aetiology and Prevalence of Patellofemoral Pain can be used to assess patellofemoral pain in young Thai patients.

Most patients with anterior cruciate ligament (ACL) injury undergo ACL reconstruction (ACLR) with the expectation of being able to return to sport (RTS) at the same level of the competition as before the injury. The magnitude and asymmetry of landing impact are important post-ACLR functional variables related to increased ACL strain and poor athletic performance. However, the association between the RTS status and landing impact in post-ACLR patients is unknown.

To investigate the association between RTS status and landing impact during single-leg landing in post-ACLR patients.

Forty-four patients after primary, unilateral ACLR participated in this study. They had already participated in sports post-ACLR. Questionnaires were used to assess whether the participants achieved the same competitive level of RTS as before the injury. The magnitude and symmetry of the peak vertical ground reaction force (pVGRF) were collected and analysed during single-leg jump landings. Additionally, knee functions (range of tion level.

In double-bundle anterior cruciate ligament reconstruction (ACLR), fixed-loop and adjustable-loop cortical suspensory devices are commonly used to fix the soft graft on the femoral side. However, few studies have compared invivo elongation of the two devices. The purpose of this study was to determine whether EndoButton CL (EB) and TightRope RT (TR), the suspensory fixation devices used in ACLR, maintained their length invivo from the time of surgery through the postoperative period in a randomized controlled trial.

This study prospectively incorporated 30 patients undergoing initial ACLR at a single center. Participants were divided into two groups using a stratified randomization method with age and sex as assignment adjustment factors. EB or TR was used for fixation of the soft graft on the femoral side. The primary endpoint was to compare the elongation distance of the suspensory device. MRIs were taken within seven days after ACLR and 3,6,12 months postoperatively and measured by a radiologist in a bEB was not verified statistically.

Total knee arthroplasty (TKA) is a common and cost-effective surgical treatment for osteoarthritis of the knee. However, only 82-89% of patients who performed TKA are satisfied with the postoperative outcomes. Therefore, bi-cruciate retaining (BCR) TKA is re-attracting attention. By retaining the anterior cruciate ligament (ACL), the knee may obtain the kinematic pathway that are closer to the native knee. The aim of the present study is to compare the ability to walk before and after surgery in patients who underwent bi-cruciate retaining total knee arthroplasty (BCR TKA) versus bi-cruciate stabilized (BCS) TKA during the early postoperative period.

Subjects included patients who underwent BCR TKA (10 knees) and BCS TKA (15 knees). We administered 10-meter gait tests before surgery and at 6 weeks and 3 months after surgery. We collected the following triaxial accelerometery data with a portable gait analyzer walking time, number of steps, velocity, stride length, and coefficient of variability (CV) of double-leg support time while walking.

Patients who underwent BCR TKA improved their gait ability [walking time (

< 0.01), number of steps (

< 0.05), velocity (

< 0.01), and stride length (

< 0.01) more than those who received BCS TKA at 6 weeks after surgery. BCR TKA improved gait ability (walking time, number of steps, velocity, and stride length) more than BCS TKA at 6 weeks after surgery. At 6 weeks after surgery, CV of double-leg support time while walking improved more in the BCR TKA group than in the BCS TKA group (

< 0.05).

BCR TKA is associated with improved gait ability in the early postoperative period.

BCR TKA is associated with improved gait ability in the early postoperative period.