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05). Correct response answers to case scenarios covering PA in disease management (specifically osteoarthritis and cancer) also improved (32% and 44% increase, respectively, p less then 0.01). Conclusion Self-guided educational tools have the potential to improve the exercise prescription skills of undergraduate medical students. Future research should compare different methods of delivering education on PA within medical schools to determine the most effective means of integrating PA into the curriculum.Purpose This study examined meta-data, source, type of informational content, understandability, and actionability of YouTube content related to speech and/or language disorders. Method The 100 most widely viewed videos related to children with speech and/or language disorders were obtained. Meta-data and sources of each upload were identified. Type of informational content within the videos was analyzed. The Patient Education Material Assessment Tool for Audiovisual Materials was used to assess understandability and actionability. Results A significant difference between video source groups was found for length of video, thumbs-up, and thumbs-down, but not for number of views. The YouTube videos related to speech and/or language disorders covered a range of issues, although a majority of the content focused on signs/symptoms and treatment. Videos had close-to-adequate understandability (i.e. 68%), although poor actionability scores (i.e. 32%) were noted. Videos uploaded by professionals were superior to other upload sources in understandability, but no difference was noted between video source for actionability. Conclusions Study insights about meta-data, source, type of informational content, understandability, and actionability of YouTube videos may help professionals understand the nature of online content related to speech and/or language disorders. Study implications and recommendations for further research are discussed.E-mental health programmes have great potential to provide young people with access to mental health support. However, it is commonly reported that adherence to these programmes is low. Low adherence can be problematic, particularly if young people do not receive the full benefits of a programme. GLPG0187 in vivo In a research trial setting, non-adherence to treatment recommendations can prevent researchers from drawing strong conclusions about effectiveness. Although adherence has been recognised as an issue in need of attention, many of the reviews available are focused on adults and lack clear direction towards what strategies to employ. This paper presents a broad review of the adherence literature, focusing on factors associated with improving adherence to e-mental health among youth. Our view on the key elements to improve adherence identified from the existing literature are presented, and key recommendations for e-mental health intervention design are provided. These include developing and communicating adherence guidelines based on individuals' needs and symptom severity, including customisable features to provide a tailored experience and promote a sense of agency, including engagement checks and adopting a user-centred approach by utilising strategies such as co-design. This paper provides guidance to intervention designers and researchers by outlining recommendations and considerations for intervention development and research design.Background Erythropoiesis-stimulating agents including epoetin alfa have been a mainstay of anemia management in patients with chronic kidney disease. Although the standard practice has been to administer epoetin alfa to patients on hemodialysis (HD) intravenously (IV), subcutaneous (SQ) epoetin alfa is longer acting and achieve the same target hemoglobin level to be maintained at a reduced dose and cost. Objective The primary objective of this study was to determine the economic benefits of change in route of epoetin alfa administration from IV to SQ in HD patients. The secondary objectives were (1) to determine the differences in epoetin alfa doses at the pre-switch (IV) and post-switch period (SQ) and (2) to determine serum hemoglobin concentration, transferrin saturation, ferritin level, IV iron dose and cost in relationship to route of epoetin alfa administration. Design This retrospective observational study included patients who transitioned from IV to SQ epoetin alfa. Setting Two HD sites in southern vels. Given the cost sparing advantages without compromising care while achieving comparable hemoglobin levels, HD units should consider converting to SQ mode of administration. Trial registration The study was not registered on a publicly accessible registry as it was a retrospective chart review and exempted from review by the Research Ethics Board of the former Regina Qu'Appelle Health Region.Background Prolonged wait times are known barriers to accessing nephrology care for patients needing more urgent specialist services. Improved process and standardized triage systems are known to minimize wait times of urgent or semi-urgent care in health care disciplines. In Central Zone (CZ) renal clinic, mean wait times for urgent (P1) and semi-urgent (P2) referrals were prolonged before 2014. We also observed prolonged wait times for elective (P3-P5) categories. Improving wait times was identified as an access to care quality improvement focus in CZ renal clinic of the Nova Scotia Health Authority (NSHA). Objectives To describe our new referral process and new triage system, and to examine their effect on number of referrals wait-listed and mean wait times. Design A quasi-experimental design was used. Setting Halifax, Nova Scotia, Canada. Participants Patients referred to Central Zone Renal Clinic between 2012 and 2018. Measurements A time series of referral counts and wait times for each triage category Quality improvement initiative.Background and objectives The risk and timing of bleeding events following ultrasound-guided percutaneous renal biopsy are not clearly defined. Design setting participants and measurements We performed a retrospective study of 617 consecutive adult patients who underwent kidney biopsy between 2012 and 2017 at a tertiary academic hospital in London, Canada. We assessed frequency and timing of minor (not requiring intervention) and major (requiring blood transfusion, surgery, or embolization) bleeds and developed a personalized risk calculator for these. Results Bleeding occurred in 79 patients (12.8%; 95% confidence interval [CI] 10.4%-15.7%). Minor bleeding occurred in 67 patients (10.9%; 95% CI 8.6%-13.6%). Major bleeding occurred in 12 patients (1.9%; 95% CI 1.1%-3.4%); 2 required embolization or surgery (0.3%; 95% CI 0.09%-1.2%) and 10 required blood transfusion (1.6%; 95% CI 0.9%-3.0%). Seventy-three of 79 events were identified immediately on post-procedure ultrasound (92.4% of cases; 95% CI 84.4%-96.5%).