Norrishammond9014

728 (0.645-0.802) and 0.732 (0.681-0.784) for the prediction of 1- and 3-year mortality, respectively. Etiology of heart failure, NYHA class, left ventricular ejection fraction, and QRS morphology had higher predictive power, whereas hemoglobin was less important in females compared to males. The importance of atrial fibrillation and age increased, while the importance of serum creatinine decreased from 1- to 3-year follow-up in both sexes. Conclusions Using ML techniques in combination with easily obtainable clinical features, our models effectively predicted 1- and 3-year all-cause mortality in CRT patients. CRCD2 compound library inhibitor Sex-specific patterns of predictors were identified, showing a dynamic variation over time.Background Transcatheter closure of paravalvular leak (PVL) has evolved into an alternative to surgery in high-risk patients. In this study, we introduce a new access for transcatheter closure of PVL and seek to evaluate the feasibility and safety of this access. Methods We retrospectively analyzed patients undergoing transbrachial access for transcatheter mitral or aortic PVL closure (August 2017-November 2019) at our hospital. All patients underwent puncture of the brachial artery under local anesthesia. Results The study population included 11 patients, with an average age of 55.91 ± 14.82 years. Ten out of 11 patients were successfully implanted with devices via the brachial artery approach, and one patient was converted to the transseptal approach. The technical success rate of transbrachial access was 90.9%. Mean NYHA functional class improved from 3.1 ± 0.5 before the procedure to 1.9 ± 0.5 after PVL closure. Severe paravalvular regurgitation (PVR) in five patients and moderate PVR in six patients prior to the procedure were significantly reduced to mild in four patients and none in seven patients after the procedure. Complications included one case of pseudoaneurysm and one case of moderate hemolysis aggravation after closure. One patient had an unknown cause of sudden death within 24 h after the procedure. The half-year mortality rate during follow-up was 9.1% (1/11). Conclusions Transbrachial access for transcatheter closure of PVL may be a feasible and safe treatment and should include well-selected patients. It has several potential advantages of simplifying the procedure process and reducing postprocedural bed rest time.Sensory feedback is essential for the control of soft robotic systems and to enable deployment in a variety of different tasks. Proprioception refers to sensing the robot's own state and is of crucial importance in order to deploy soft robotic systems outside of laboratory environments, i.e. where no external sensing, such as motion capture systems, is available. A vision-based sensing approach for a soft robotic arm made from fabric is presented, leveraging the high-resolution sensory feedback provided by cameras. link2 No mechanical interaction between the sensor and the soft structure is required and consequently the compliance of the soft system is preserved. The integration of a camera into an inflatable, fabric-based bellow actuator is discussed. Three actuators, each featuring an integrated camera, are used to control the spherical robotic arm and simultaneously provide sensory feedback of the two rotational degrees of freedom. A convolutional neural network architecture predicts the two angles describing the robot's orientation from the camera images. Ground truth data is provided by a motion capture system during the training phase of the supervised learning approach and its evaluation thereafter. link3 The camera-based sensing approach is able to provide estimates of the orientation in real-time with an accuracy of about one degree. The reliability of the sensing approach is demonstrated by using the sensory feedback to control the orientation of the robotic arm in closed-loop.The human ability of keeping balance during various locomotion tasks is attributed to our capability of withstanding complex interactions with the environment and coordinating whole-body movements. Despite this, several stability analysis methods are limited by the use of overly simplified biped and foot structures and corresponding contact models. As a result, existing stability criteria tend to be overly restrictive and do not represent the full balance capabilities of complex biped systems. The proposed methodology allows for the characterization of the balance capabilities of general biped models (ranging from reduced-order to whole-body) with segmented feet. Limits of dynamic balance are evaluated by the Boundary of Balance (BoB) and the associated novel balance indicators, both formulated in the Center of Mass (COM) state space. Intermittent heel, flat, and toe contacts are enabled by a contact model that maps discrete contact modes into corresponding center of pressure constraints. For demonstration puation of balance capabilities provides an important benchmarking framework for the stability of general biped/foot systems.Flexible endoscopy involves the insertion of a long narrow flexible tube into the body for diagnostic and therapeutic procedures. In the gastrointestinal (GI) tract, flexible endoscopy plays a major role in cancer screening, surveillance, and treatment programs. As a result of gas insufflation during the procedure, both upper and lower GI endoscopy procedures have been classified as aerosol generating by the guidelines issued by the respective societies during the COVID-19 pandemic-although no quantifiable data on aerosol generation currently exists. Due to the risk of COVID-19 transmission to healthcare workers, most societies halted non-emergency and diagnostic procedures during the lockdown. The long-term implications of stoppage in cancer diagnoses and treatment is predicted to lead to a large increase in preventable deaths. Robotics may play a major role in this field by allowing healthcare operators to control the flexible endoscope from a safe distance and pave a path for protecting healthcare workers through minimizing the risk of virus transmission without reducing diagnostic and therapeutic capacities. This review focuses on the needs and challenges associated with the design of robotic flexible endoscopes for use during a pandemic. The authors propose that a few minor changes to existing platforms or considerations for platforms in development could lead to significant benefits for use during infection control scenarios.Researchers continue to devise creative ways to explore the extent to which people perceive robots as social agents, as opposed to objects. One such approach involves asking participants to inflict 'harm' on a robot. Researchers are interested in the length of time between the experimenter issuing the instruction and the participant complying, and propose that relatively long periods of hesitation might reflect empathy for the robot, and perhaps even attribution of human-like qualities, such as agency and sentience. In a recent experiment, we adapted the so-called 'hesitance to hit' paradigm, in which participants were instructed to hit a humanoid robot on the head with a mallet. After standing up to do so (signaling intent to hit the robot), participants were stopped, and then took part in a semi-structured interview to probe their thoughts and feelings during the period of hesitation. Thematic analysis of the responses indicate that hesitation not only reflects perceived socialness, but also other factors including (but not limited to) concerns about cost, mallet disbelief, processing of the task instruction, and the influence of authority. The open-ended, free responses participants provided also offer rich insights into individual differences with regards to anthropomorphism, perceived power imbalances, and feelings of connection toward the robot. In addition to aiding understanding of this measurement technique and related topics regarding socialness attribution to robots, we argue that greater use of open questions can lead to exciting new research questions and interdisciplinary collaborations in the domain of social robotics.As service robots become increasingly autonomous and follow their own task-related goals, human-robot conflicts seem inevitable, especially in shared spaces. Goal conflicts can arise from simple trajectory planning to complex task prioritization. For successful human-robot goal-conflict resolution, humans and robots need to negotiate their goals and priorities. For this, the robot might be equipped with effective conflict resolution strategies to be assertive and effective but similarly accepted by the user. In this paper, conflict resolution strategies for service robots (public cleaning robot, home assistant robot) are developed by transferring psychological concepts (e.g., negotiation, cooperation) to HRI. Altogether, fifteen strategies were grouped by the expected affective outcome (positive, neutral, negative). In two online experiments, the acceptability of and compliance with these conflict resolution strategies were tested with humanoid and mechanic robots in two application contexts (public n 1 = 61;esolution strategies based on Human Factors and Social Psychology are introduced and empirically evaluated in two online studies for two application contexts. Influencing factors and requirements for the acceptance and effectiveness of robot assertiveness are discussed.Extracellular vesicles are cell-derived membranous vesicles that are secreted into biofluids. Emerging evidence suggests that EVs play an essential role in the pathogenesis of many diseases by transferring proteins, genetic material, and small signaling molecules between cells. Among these molecules, microRNAs (miRNAs), a type of small noncoding RNA, are one of the most important signals and are involved in various biological processes. Lung cancer is one of the leading causes of cancer-related deaths worldwide. Early diagnosis of lung cancer may help to reduce mortality and increase the 5 years survival rate and thereby reduce the associated socioeconomic burden. In the past, EV-miRNAs have been recognized as biomarkers of several cancers to assist in diagnosis or prognosis. In this review, we discuss recent findings and clinical practice for EV-miRNAs of lung cancer in several biofluids, including blood, bronchoalveolar lavage fluid (BALF), and pleural lavage.Drug repurposing is also termed as drug repositioning or therapeutic switching. This method is applied to identify the novel therapeutic agents from the existing FDA approved clinically used drug molecules. It is considered as an efficient approach to develop drug candidates with new pharmacological activities or therapeutic properties. As the drug discovery is a costly, time-consuming, laborious, and highly risk process, the novel approach of drug repositioning is employed to increases the success rate of drug development. This strategy is more advantageous over traditional drug discovery process in terms of reducing duration of drug development, low-cost, highly efficient and minimum risk of failure. In addition to this, World health organization declared Coronavirus disease (COVID-19) as pandemic globally on February 11, 2020. Currently, there is an urgent need to develop suitable therapeutic agents for the prevention of the outbreak of COVID-19. So, various investigations were carried out to design novel drug molecules by utilizing different approaches of drug repurposing to identify drug substances for treatment of COVID-19, which can act as significant inhibitors against viral proteins.