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CMEL is a novel, less invasive, technique that allows for multilevel posterior cervical decompression for treatment of CSM. Our 5-year follow-up data demonstrates that patients after CMEL have similar neurological outcomes to conventional laminoplasty, with significantly less postoperative axial pain and improved subaxial cervical lordosis when compared with their traditional laminoplasty counterparts.

This was a retrospective cohort study of a national dataset.

The purpose of this study was to consider the influence of frailty on the development of hospital-acquired conditions (HACs) in adult spinal deformity (ASD).

HACs frequently include reasonably preventable complications. Eleven events are identified as HACs by the Affordable Care Act. In the surgical ASD population, factors leading to HACs are important to identify to optimize health care.

Patients 18 years and older undergoing corrective surgery for ASD identified in the American College of Surgeons' National Surgical Quality Improvement Program (ACS-NSQIP). The relationship between HACs and frailty as defined by the NSQIP modified 5-factor frailty index (mFI-5) were assessed using χ2 and independent sample t tests. The mFI-5 is assessed on a scale 0-1 [not frail (NF) <0.3, mildly frail (MF) 0.3-0.5, and severely frail (SF) > 0.5]. Binary logistic regression measured the relationship between frailty throughout HACs.

A total of 9143 A379; P=0.009).

For patients undergoing correction surgery for ASD, the incidence of HACs increased with worsening frailty score. Such findings suggest the importance of medical optimization before surgery for ASD.

For patients undergoing correction surgery for ASD, the incidence of HACs increased with worsening frailty score. Such findings suggest the importance of medical optimization before surgery for ASD.

Androgen receptor (AR) expression is a potential therapeutic target in breast cancer (BC) as it is frequently expressed in the luminal A and B subtypes and in approximately one third of basal-like cancers. As AR-positive BC displays a distinct biological behavior, we aimed to analyze AR expression in the particular context of BC brain metastases (BM).

Patients with newly diagnosed BC BM treated with neurosurgical resection were identified from the Vienna Brain Metastasis Registry and clinical data including patient characteristics, biological tumor subtypes and overall survival were obtained by retrospective chart review. Formalin-fixed and paraffin-embedded specimen containing BM tissue were retrieved from the Neuro-Biobank. Immunohistochemical staining of AR was performed and AR expression in the tumor-cell nucleus was evaluated.

Fifty-seven BM samples from 57 individual patients with BC were available for this analysis. AR expression of ≥1% tumor cells was evident in 20/57 (35.1%) BM specimens; the median AR-expression rate was 10% (range 1% to 60%). AR expression was observed in 11/21 (52.4%) BM of the luminal/human epidermal growth factor receptor 2 (HER2)-negative subtype, 3/13 (23.1%) of the luminal/HER2-positive subtype, 2/7 (28.6%) of the HER2-positive subtype and 4/16 (25.0%) of the triple-negative subtype (P=0.247). Median survival from diagnosis of BM was 10 months (range 0 to 104 mo) in the entire cohort. No significant association of overall survival and AR expression ≥1% was observed (15 vs. 13 mo; P>0.05).

AR is expressed in more than one third of BC BM with the highest rates among the luminal/HER2-negative BC subtype and may therefore be a potential prognostic and predictive biomarker in this particular BC population.

AR is expressed in more than one third of BC BM with the highest rates among the luminal/HER2-negative BC subtype and may therefore be a potential prognostic and predictive biomarker in this particular BC population.

The objectives were to assess US medical students' awareness about PM&R, their career goals that may align with PM&R, their exposure to PM&R, and compare the demographics of those applying to, interested or not interested in PM&R residency. This was a descriptive cross-sectional study. An online survey was distributed to 76 medical schools and 2067 students responded. First generation and Hispanic/Latino students are less likely to know about PM&R. Medical students who heard about PM&R before or during college or who are first-generation students to attend medical school are more likely to be interested in PM&R. https://www.selleckchem.com/products/bx-795.html Medical students identified as female, Black or African-American, and more advanced in medical training have lesser interest. Rotating in PM&R at their home institution and shadowing a PM&R physician also increases the likelihood of respondents to apply to PM&R residency. This study highlights that females and underrepresented minorities in medicine are less lor African-American, and more advanced in medical training have lesser interest. Rotating in PM&R at their home institution and shadowing a PM&R physician also increases the likelihood of respondents to apply to PM&R residency. This study highlights that females and underrepresented minorities in medicine are less likely to know about PM&R or be interested in PM&R. First generation medical students know less about the field but the ones that do have increased interest in PM&R. These findings support the need for pipeline programs to improve exposure, recruitment, development, promotion, and retention of first-generation minorities and women into PM&R.

Our objectives were to explore the association between phosphodiesterase 5 inhibitor (PDE5i) use and lumbar decompression surgery (LDS) by evaluating the prevalence of LDS in a treatment group of patients with lumbar spinal stenosis (LSS) compared to a control group.

We performed database review and extracted data including LDS prevalence, PDE5i dosage and fill dates. Treatment group was defined as those with PDE5i fill dates less than 30 days prior to surgery, and control group was defined as those with PDE5i fill dates at any other time. LDS prevalence rates for both groups were calculated.

Our study found 599 LSS patients who were prescribed PDE5i. 338 underwent LDS. Of these, 71 (21%) filled their prescription less than 30 days prior to surgery, while 267 (79%) filled their prescription during a different time period. The majority (94.6%) of surgical patients received decompression at 2-or-more spinal levels.

Prevalence of LDS for LSS was significantly lower in patients in the treatment group on PDE5i therapy compared to the control group.