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9%) in full-term births, and 42.2% (95% CI, 39.1%-45.3%) in preterm births. After adjustment, the prevalence of MSM was 42% higher in preterm births. Breastfeeding duration and pacifier use up to age 4 years modified the effect of gestational age on MSM. Conclusions Preterm birth is associated with the development of MSM. Breastfeeding reduces the effect of preterm birth on MSM, and pacifier use strengthens this association. Dentists should be aware that preterm birth may be a risk factor for malocclusion in primary dentition. The findings reinforce the benefits of breastfeeding on occlusal development and the negative consequences of pacifier use.Introduction The mechanical properties of Invisalign material have rarely been explored because of the inaccessibility of the patent-protected raw material. The purpose of this study was to systematically evaluate the Invisalign thermoformed aligner material before and after clinical application, including mechanical properties, surface morphology, internal structure, and chemical composition changes. Methods Twenty sets of "as-received" (0-week) and retrieved (2-week; worn for 2 weeks, 20 ± 2 hours per day) Invisalign aligners were randomly collected from 4 different patients. Tensile tests, stress relaxation, and creep tests were carried out with a dynamic mechanical analyzer to characterize the changes in the mechanical properties of this material, Fourier transform infrared spectroscopy was used to capture the molecular changes on the surface of these aligners, scanning electron microscopy and transmission electron microscopy were used to observe the changes in surface morphology and internal structure, aal were relatively stable under the oral environment. Conclusions The surface morphology showed some defects after the clinical use of 2 weeks; however, there was no significant difference in mechanical properties. Trace elements may release out during clinical use and may pose a specific danger to allergic patients.Introduction Currently, there is limited evidence on the effects of malocclusion on oral health and whether the correction of malocclusion results in an improvement in oral health. In this review, we examined the evidence from randomized controlled trials and prospective cohort studies to provide information on any association between malocclusion and oral health and the effects of orthodontic treatment. Methods We conducted this review in 2 parts (1) we looked at the impact of malocclusion on oral health, and (2) we reviewed the evidence on the effect of orthodontic treatment on oral health. We searched for randomized controlled trials and prospective cohort studies. The searches were completed for articles published between January 1, 1990 and October 8, 2018 and covered Medline via Ovid, Embase, and the Cochrane Database of Systematic Reviews. References of included articles and previous systematic reviews were hand-searched. No language restrictions were applied. Two members of the study team assessed the of the study, we identified 87 studies. The overall quality was low. We could not include any of the data into an analysis because of a large variation in the nature of the studies, data collected, and outcome measures that were selected. For part 2 of the study, we found 7 studies; however, there were similar deficiencies in the data as in part 1, and thus, we could not reach any strong conclusions. Conclusions Overall, there is an absence of published evidence regarding the effects of malocclusion on oral health and the impact of orthodontic treatment on oral health.Human papillomavirus (HPV) is a sexually transmitted infection common among both men and women (1). HPV vaccination, which requires multiple doses, was first recommended for girls in 2006 and for boys in 2011 (2,3). Vaccination is routinely recommended at 11-12 years and can be started at age 9 (4). For those not vaccinated at 11-12 years, vaccination is recommended for all persons through age 26 years (4). Two HPV vaccine doses, given 6 to 12 months apart, are recommended if the series is started before age 15. Three doses, to be completed within 6 months, are recommended for those who started vaccination at age 15 or over (4,5). This report describes trends in selfreported HPV vaccination initiation and completion by selected demographic characteristics among adults aged 18-26.This report presents final 2018 U.S. mortality data on deaths and death rates by demographic and medical characteristics. These data provide information on mortality patterns among U.S. residents by variables such as sex, age, race and Hispanic origin, and cause of death. Life expectancy estimates, 10 leading causes of death, age-specific death rates, and 10 leading causes of infant death were analyzed by comparing 2018 and 2017 final data.In 2018, an estimated 8.1 million U.S. adults were current electronic cigarette (e-cigarette) users (1). E-cigarette use is a public health concern (2), and it has been linked to a recent outbreak of lung injury and deaths among adults (3). Although the potential long-term health risks of e-cigarettes are not yet as well-known as they are with cigarettes, e-cigarettes usually contain nicotine, and nicotine is highly addictive (2). Moreover, the most common tobacco product combination among adults is e-cigarettes and cigarettes (4). This report examines e-cigarette use among U.S. adults aged 18 and over by selected sociodemographic characteristics and in relation to cigarette smoking status.Previously published data from the National Health Interview Survey (NHIS) found that in 2017 one in seven persons under age 65 was in a family having problems paying medical bills (1). Significant expenses for one family member may adversely affect the whole family (2). People who are in families with problems paying medical bills may experience serious financial consequences, such as having problems with paying for food, clothing, or housing, and filing for bankruptcy (3). Health insurance coverage status (i.e., uninsured, public coverage, or private coverage) may also impact the ability to afford health care costs (4). This report examines characteristics of persons who live in families that have problems paying medical bills.Hepatitis B virus (HBV) is a type of viral hepatitis transmitted through sexual contact, contaminated blood, or from an infected mother to her newborn (1). HBV may cause a liver infection that is acute or short-term, but may also cause chronic or long-term infection. Vaccination was targeted to high-risk groups in 1982, and universal vaccination of newborns was recommended beginning in 1991 in the United States (2). This report provides 2015-2018 prevalence estimates of past or present HBV infection and evidence of hepatitis B vaccination, based on blood collected in the National Health and Nutrition Examination Survey (NHANES).Hypertension is a major risk factor for cardiovascular disease. Lowering blood pressure has been shown to decrease the incidences of stroke, heart attack, and heart failure (1,2). This report provides 2017-2018 U.S. hypertension prevalence estimates using the 2017 American College of Cardiology and American Heart Association definition of hypertension (3) and new guidelines, which redefine hypertension by lowering the previous threshold levels of 140/90 mmHg to 130/80 mmHg (4). This change categorizes a greater percentage of people as having hypertension.For the first time since 2004 (1), national data on vaginal birth after cesarean delivery (VBAC) became available in 2016 after all reporting areas implemented the 2003 revision of the U.S. Standard Certificate of Live Birth. Women who deliver vaginally after a previous cesarean are less likely to experience birth-related morbidity such as blood transfusion, ruptured uterus, unplanned hysterectomy, and admission to the Intensive Care Unit than women who have repeat cesareans (2). This report describes recent trends in the VBAC rates by maternal age, race and Hispanic origin, mother's state of residence, and gestational age of the newborn from 2016 to 2018.Attention-deficit/hyperactivity disorder (ADHD) and learning disabilities are the most commonly diagnosed neurodevelopmental disorders in children and often coexist (1,2). Previous research has suggested that the prevalence of these conditions may differ by race and Hispanic origin (3,4). Using timely, nationally representative data, this report examines the reported prevalence of ADHD and learning disabilities by race and ethnicity and select demographic characteristics that are associated with the diagnosis of these conditions (1).Suicide is the 10th leading cause of death for all ages in the United States (1). Suicide is a major contributor to premature mortality as it ranks as the second leading cause of death for ages 10-34 and the fourth leading cause for ages 35-54 (1). Despite national goals to lower the suicide rate (2), several recent reports have documented a steady increase in suicide rates in recent years (3-6). This data brief uses final mortality data from the National Vital Statistics System (NVSS) to update trends in suicide rates from 1999 through 2018 and to describe differences by sex, age group, and urbanicity of county of residence.Monitoring sexual activity and contraceptive use among teenagers aged 15-19 in the United States informs understanding of the risk of pregnancy. By 2018, the U.S. birth rate for teenagers dropped 72% from its peak in 1991 (1), paralleling a decline in the teen pregnancy rate (1,2). While this represents progress toward national goals, these rates are still higher than those in other developed countries (3,4). Using data from the 2002 through 2015-2017 National Survey of Family Growth (NSFG), this report provides trends and national estimates of sexual activity and contraceptive use among teenagers.Deaths from drug overdose continue to contribute to mortality in the United States (1-5). This report uses the most recent data from the National Vital Statistics System (NVSS) to update trends in drug overdose deaths for all drugs and for specific drugs and drug types, and to identify changes in rates by state from 2017 to 2018.Obesity is associated with serious health risks (1). Severe obesity further increases the risk of obesity-related complications, such as coronary heart disease and end-stage renal disease (2,3). From 1999-2000 through 2015-2016, a significantly increasing trend in obesity was observed (4). This report provides the most recent national data for 2017-2018 on obesity and severe obesity prevalence among adults by sex, age, and race and Hispanic origin. Trends from 1999-2000 through 2017-2018 for adults aged 20 and over are also presented.We analyzed transmission of coronavirus disease outside of the Daegu-Gyeongsangbuk provincial region in South Korea. We estimated that nonpharmaceutical measures reduced transmissibility by a maximum of 34% without resorting to a strict lockdown strategy. To optimize epidemic control, continuous efforts to monitor the transmissibility are needed.There are few detailed investigations of neurologic complications in severe acute respiratory syndrome coronavirus 2 infection. We describe 3 patients with laboratory-confirmed coronavirus disease who development of encephalopathy and encephalitis. Neuroimaging showed nonenhancing unilateral, bilateral, and midline changes not readily attributable to vascular causes. INCB059872 All 3 patients had increased cerebrospinal fluid (CSF) levels of anti-S1 IgM. One patient who died also had increased levels of anti-envelope protein IgM. CSF analysis also showed markedly increased levels of interleukin (IL)-6, IL-8, and IL-10, but severe acute respiratory syndrome coronavirus 2 was not identified in any CSF sample. These changes provide evidence of CSF periinfectious/postinfectious inflammatory changes during coronavirus disease with neurologic complications.

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