Mikkelsendueholm6861

Whole gland prostate cancer treatment, i.e. radical prostatectomy or radiation therapy, is highly effective but also comes with a significant impact on quality of life and possible overtreatment in males with low to intermediate risk disease. Minimal-invasive treatment strategies are emerging techniques. Different sources of energy are used to aim for targeted treatment in order to reduce treatment-related complications and morbidity. Imaging plays an important role in targeting and monitoring of treatment approaches preserving parts of the prostatic tissue. Multiparametric magnetic resonance imaging (mpMRI) is widely used during image-guided interventions due to the multiplanar and real-time anatomical imaging while providing an improved treatment accuracy. This review evaluates the available image-guided prostate cancer treatment options using MRI or magnetic resonance imaging/transrectal ultrasound (MRI/TRUS)-fusion guided imaging. The discussed minimal invasive image-guided prostate interventions may be considered as safe and feasible partial gland ablation in patients with (recurrent) prostate cancer. However, most studies focusing on minimally invasive prostate cancer treatments only report early stages of research and subsequent high-level evidence is still needed. TVB-3166 mouse Ensuring a safe and appropriate utilization in patients that will benefit the most, and applied by physicians with relevant training, has become the main challenge in minimally invasive prostate cancer treatments.

Quantify target volume delineation uncertainty for CT/MRI simulation and MRI-guided adaptive radiotherapy in rectal cancer. Define optimal imaging sequences for target delineation.

Six experienced radiation oncologists delineated CTVs on CT and 2D and 3D-MRI in three patients with rectal cancer, using consensus contouring guidelines. Tumour GTV (GTVp) was also contoured on MRI acquired week 0 and 3 of radiotherapy. A STAPLE contour was created and volume and interobserver variability metrics were analysed.

There were statistically significant differences in volume between observers for CT and 2D-MRI-defined CTVs (

< 0.05). There was no significant difference between observers on 3D-MRI. Significant differences in volume were seen between observers for both 2D and 3D-MRI-defined GTVp at weeks 0 and 3 (

< 0.05). Good interobserver agreement (IOA) was seen for CTVs delineated on all imaging modalities with best IOA on 3D-MRI; median Conformity Index (CI) 0.74 for CT, 0.75 for 2D-MRI and 0.77 for 3D-MRI. IOA of MRI-defined GTVp week 0 was better compared to CT; CI 0.58 for CT, 0.62 for 2D-MRI and 0.7 for 3D-MRI. MRI-defined GTVp IOA week three was worse compared to week 0.

Delineation on MRI results in smaller volumes and better IOA week 0 compared to CT. 3D-MRI provides the best IOA in CTV and GTVp. MRI-defined GTVp on images acquired week three showed worse IOA compared to week 0. This highlights the need for consensus guidelines in GTVp delineation on MRI during treatment course in the context of dose escalation MRI-guided rectal boost studies.

Optimal MRI sequences for CT/MRI simulation and MRI-guided adaptive radiotherapy in rectal cancer have been defined.

Optimal MRI sequences for CT/MRI simulation and MRI-guided adaptive radiotherapy in rectal cancer have been defined.This corrects the article DOI 10.1103/PhysRevLett.126.161301.We introduce a computational method for global optimization of structure and ordering in atomic systems. The method relies on interpolation between chemical elements, which is incorporated in a machine-learning structural fingerprint. The method is based on Bayesian optimization with Gaussian processes and is applied to the global optimization of Au-Cu bulk systems, Cu-Ni surfaces with CO adsorption, and Cu-Ni clusters. The method consistently identifies low-energy structures, which are likely to be the global minima of the energy. For the investigated systems with 23-66 atoms, the number of required energy and force calculations is in the range 3-75.We propose a relativistic gravitational theory leading to modified Newtonian dynamics, a paradigm that explains the observed universal galactic acceleration scale and related phenomenology. We discuss phenomenological requirements leading to its construction and demonstrate its agreement with the observed cosmic microwave background and matter power spectra on linear cosmological scales. We show that its action expanded to second order is free of ghost instabilities and discuss its possible embedding in a more fundamental theory.Correlations between the spins of top-quark pairs produced at a collider can be used to probe quantum entanglement at energies never explored so far. We show how the measurement of a single observable can provide a test of the violation of a Bell inequality at the 98% C.L. with the statistical uncertainty of the data already collected at the Large Hadron Collider, and at the 99.99% C.L. with the higher luminosity of the next run. Detector acceptance, efficiency, and migration effects are taken into account. The test relies on the spin correlations alone and does not require the determination of probabilities-in contrast to all other tests of Bell inequalities.In a certain class of scalar-Gauss-Bonnet gravity, the black holes and the neutron stars can undergo spontaneous scalarization-a strong gravity phase transition triggered by a tachyonic instability due to the nonminimal coupling between the scalar field and the spacetime curvature. Studies of this phenomenon have, so far, been restricted mainly to the study of the tachyonic instability and stationary scalarized black holes and neutron stars. To date, no realistic physical mechanism for the formation of isolated scalarized black holes and neutron stars has been proposed. We study, for the first time, the spherically symmetric fully nonlinear stellar core collapse to a black hole and a neutron star in scalar-Gauss-Bonnet theories allowing for a spontaneous scalarization. We show that the core collapse can produce scalarized black holes and scalarized neutron stars starting with a nonscalarized progenitor star. The possible paths to reach the end (non)scalarized state are quite rich leading to interesting possibilities for observational manifestations.Single photons exhibit inherently quantum and unintuitive properties such as the Hong-Ou-Mandel effect, demonstrating their bosonic and quantized nature, yet at the same time may correspond to single excitations of spatial or temporal modes with a very complex structure. Those two features are rarely seen together. Here we experimentally demonstrate how the Hong-Ou-Mandel effect can be spectrally resolved and harnessed to characterize a complex temporal mode of a single-photon-a zero-area pulse-obtained via a resonant interaction of a terahertz-bandwidth photon with a narrow gigahertz-wide atomic transition of atomic vapor. The combination of bosonic quantum behavior with bandwidth-mismatched light-atom interaction is of fundamental importance for deeper understanding of both phenomena, as well as their engineering offering applications in characterization of ultrafast transient processes.It is shown that the Ablowitz-Kaup-Newell-Segur (AKNS) integrable hierarchy can be obtained as the dynamical equations of three-dimensional general relativity with a negative cosmological constant. This geometrization of the AKNS system is possible through the construction of novel boundary conditions for the gravitational field. These are invariant under an asymptotic symmetry group characterized by an infinite set of AKNS commuting conserved charges. Gravitational configurations are studied by means of SL(2,R) conjugacy classes. Conical singularities and black hole solutions are included in the boundary conditions.Studying spin-momentum correlations in hadronic collisions offers a glimpse into a three-dimensional picture of proton structure. The transverse single-spin asymmetry for midrapidity isolated direct photons in p^↑+p collisions at sqrt[s]=200  GeV is measured with the PHENIX detector at the Relativistic Heavy Ion Collider (RHIC). Because direct photons in particular are produced from the hard scattering and do not interact via the strong force, this measurement is a clean probe of initial-state spin-momentum correlations inside the proton and is in particular sensitive to gluon interference effects within the proton. This is the first time direct photons have been used as a probe of spin-momentum correlations at RHIC. The uncertainties on the results are a 50-fold improvement with respect to those of the one prior measurement for the same observable, from the Fermilab E704 experiment. These results constrain gluon spin-momentum correlations in transversely polarized protons.β cells are biologically essential for humans and other vertebrates. Because their functionality arises from cell-cell interactions, they are also a model system for collective organization among cells. There are currently two contradictory pictures of this organization the hub-cell idea pointing at leaders who coordinate the others, and the electrophysiological theory describing all cells as equal. We use new data and computational modeling to reconcile these pictures. We find via a network representation of interacting β cells that leaders emerge naturally (confirming the hub-cell idea), yet all cells can take the hub role following a perturbation (in line with electrophysiology).Controlling and sensing spin polarization of electrons forms the basis of spintronics. Here, we report a study of the effect of helium on the spin polarization of the tunneling current and magnetic contrast in spin-polarized scanning tunneling microscopy (SP STM). We show that the magnetic contrast in SP STM images recorded in the presence of helium depends sensitively on the tunneling conditions. From tunneling spectra and their variation across the atomic lattice we establish that the helium can be reversibly ejected from the tunneling junction by the tunneling electrons. The energy of the tunneling electrons required to eject the helium depends on the relative spin polarization of the tip and sample, making the microscope sensitive to the magnetic exchange interactions. We show that the time-averaged spin polarization of the tunneling current is suppressed in the presence of helium and thereby demonstrate voltage control of the spin polarization of the tunneling current across the tip-sample junction.We combine adaptive template fitting and pixel count statistics in order to assess the nature of the Galactic Center excess in Fermi-LAT data. We reconstruct the flux distribution of point sources well below the Fermi-LAT detection threshold, and measure their radial and longitudinal profiles in the inner Galaxy. We find that all point sources and the bulge-correlated diffuse emission each contributes O(10%) of the total inner Galaxy emission, and disclose a potential subthreshold point-source contribution to the Galactic Center excess.Compressing electron pulses is important in many applications of electron beam systems. In this study, we propose to use optical beat notes to compress electron pulses. The beat frequency is chosen to match the initial electron pulse duration, which enables the compression of electron pulses with a wide range of durations. This functionality extends the optical control of electron beams, which is important in compact electron beam systems such as dielectric laser accelerators. We also find that the dominant frequency of the electron charge density changes continuously along its drift trajectory, which may open up new opportunities in coherent interaction between free electrons and quantum or classical systems.