Medlinfog1387
SEM images demonstrated a particle size between 17 and 41 nm. Although some liver enzymes and hematological parameters increased with increasing dose of extract, there was no significant difference (p>0.05) between oral administrations of CuNPs at doses of 1000, 2000, and 5000 μg/kg and the control group.
The findings revealed that CuNPs biosynthesized from aqueous extract of
fruit have no toxic effects on the liver functions and hematological parameters of mice. However, more studies are needed for evaluation of the hepatoprotective effects of CuNPs.
The findings revealed that CuNPs biosynthesized from aqueous extract of C. spinosa fruit have no toxic effects on the liver functions and hematological parameters of mice. However, more studies are needed for evaluation of the hepatoprotective effects of CuNPs.
Therapy of pain syndromes involves exposure to its source, receptors, and peripheral fibers. Treatment of acute pain and inflammation involves the use of nonsteroidal anti-inflammatory drugs and nonnarcotic analgesics. An alternative to obsolete analgesics is combined compositions. Experimental results clearly indicates that caffeine effectively enhances the peripheral analgesic activity when combined in an analgesic. The aim of the present study was to evaluate the peripheral analgesic activity of meloxicam, piroxicam, and their pharmacological combinations with caffeine.
The peripheral analgesic activity of piroxicam, meloxicam, and their combinations with caffeine was studied using the abdominal writhing test. This method was used to induce pain of peripheral origin by intraperitoneal injection of 0.6% acetic acid solution. The investigated drugs, their combinations, and 3% starch mucilage were administrated 1 h before the introduction of the algogen. The cumulative number of writhing responses induced by acetic acid was determined over the subsequent 20 min.
All investigated drugs supplied a decrease in writhing in rats. Meloxicam and caffeine showed peripheral analgesic activity of 63.6% and 64.5%, respectively (p<0.05). The pharmaceutical combination of meloxicam and caffeine showed analgesic potential of 76.4%. Thus, caffeine potentiates the analgesic activity of meloxicam. The results exceeded the corresponding value of diclofenac sodium (67.3%).
Experimental results clearly indicates that caffeine effectively enhances the peripheral analgesic action of meloxicam when combined in a pharmaceutical composition. These results can serve as a basis for the development of new domestic combined drugs.
Experimental results clearly indicates that caffeine effectively enhances the peripheral analgesic action of meloxicam when combined in a pharmaceutical composition. These results can serve as a basis for the development of new domestic combined drugs.
The aim of the study was to investigate the electrochemical behavior of rifampicin (RIF) in the anodic direction using multi-walled carbon nanotube (MWCNT)-modified glassy carbon electrodes.
The anodic investigation of RIF was carried out with cyclic, differential pulse, and square wave voltammetry. A three-electrode system consisting of a glassy carbon electrode with a modification by MWCNTs as the working electrode, a platinum wire as the counter electrode, and an Ag/AgCl electrode as reference was used for the experiments.
The anodic process of RIF was irreversible and diffusion controlled. Linear responses were obtained between 0.04 and 10 μM for both techniques in acetate buffer (pH 3.5) as supporting electrolyte. learn more The limit of detection values were 7.51 and 11.3 nM for differential pulse and square wave voltammetry, respectively. The repeatability, reproducibility, precision, and accuracy of the proposed methods were also investigated. Determination of RIF was carried out on its pharmaceutical dosage forms and the results were compared with those from other electrochemical sensors and the liquid chromatographic and spectrophotometric methods in the literature.
These validated techniques provided selective, rapid, sensitive, precise, and cheap determination of RIF as alternative techniques to the liquid chromatographic and spectrophotometric methods in therapeutic drug monitoring.
These validated techniques provided selective, rapid, sensitive, precise, and cheap determination of RIF as alternative techniques to the liquid chromatographic and spectrophotometric methods in therapeutic drug monitoring.
In the present investigation, bioadhesive buccal tablets were prepared using the sustained-release polymer hydroxypropyl methylcellulose (HPMC) K100M, bioadhesive polymer neem gum, and an impervious backing layer of ethyl cellulose. Nicorandil is sensitive to the first-pass effect; therefore, a buccal-adhesive dosage form can avoid this effect.
We used the direct compression technique to prepare the tablet formulation. A 3
full factorial design was composed in which the amounts of HPMC K100M (X1) and neem gum (X2) were chosen as the independent variables and the dependent variables were the percentage drug release at 6 h (Y1) and mucoadhesive strength in grams (Y2). Various
parameters, i.e. thickness, friability, hardness, weight variation, surface pH, moisture absorption ratio, dissolution studies, and drug release kinetics, and
parameters like mucoadhesive strength and mucoadhesion time were determined for the prepared tablets. We subjected the optimized batch to a comparison with the marketed formulation and stability studies were performed.
The formulation containing a 5050 ratio of neem gum and HPMC K100M (F5) was considered optimum. The zero-order release kinetics model best fitted the optimized batch release profile, suggesting the system would release the drug at a constant rate.
The release by the optimized formulation of the drug at a sustained rate along with its bioadhesive nature showed that the buccal route can be an option for the administration of nicorandil.
The release by the optimized formulation of the drug at a sustained rate along with its bioadhesive nature showed that the buccal route can be an option for the administration of nicorandil.
