Mcknightmccarty0804

Utilizing social media platforms can augment medical conferences by sharing new knowledge and information through hashtags. We aim to investigate the use of Twitter, enhanced conference experience, and education at the Eastern Association for the Surgery of Trauma (EAST) Annual Scientific Assembly 2016-2020.

EAST hashtags were analyzed for the Annual Scientific Assembly 2016-2020 #EAST2016, #EAST2017, #EAST2018, #EAST2019, and #EAST2020. Using #EAST2016 as a baseline, active interaction through engagement, measured by tweets and retweets, passive interaction through impressions, measured by views, as well as users, and influencers were analyzed.

2016-2018 saw a significant increase in engagement (7400 to 9200 to 11 000, respectively,

< .05). 2018-2020 then showed a significant decrease in engagement (11 000 to 9000 to 6700, respectively,

< .05). Impressions, increased significantly from 2016 to 2020 (6.6 million to 13.3 million to 12.6 million to 19.9 million to 20.3 million, respectively,

maybe a result of social media fatigue. Although, #EAST2016-2020 showed a significant increase in impressions. Both passive and to a more extent active forms of online social media engagement can potentially disseminate new knowledge and medical information. Scientific societies should focus on more effective ways to maintain and enhance users' online experience and engagement toward better utilization of social media platforms.We developed a chromium-catalyzed, photochemical, and linear-selective alkylation of aldehydes with alkylzirconium species generated in situ from a wide range of alkenes and Schwartz's reagent. Photochemical homolysis of the C-Zr bond afforded alkyl radicals, which were then trapped by a chromium complex catalyst to generate the alkylchromium(III) species for polar addition to aldehydes. The reaction proceeded with high functional group tolerance at ambient temperature under visible-light irradiation.In this paper, we obtain maps of the spatial tunnel barrier variations in self-assembled monolayers of organosulfurs on Au(111). Maps down to the sub-nanometer scale are obtained by combining topographic scanning tunneling microscopy images with dI/dz spectroscopy. The square root of the tunnel barrier height is directly proportional to the local work function and the dI/dz signal. We use ratios of the tunnel barriers to study the work function contrast in various decanethiol phases the lying-down striped β phase, the dense standing-up φ phase, and the oxidized decanesulfonate λ phase. We compare the induced work function variations too the work function contrast induced by a lying-down striped phase in comparison to the modulation induced by the standing-up φ phase, as well as the oxidized λ phase. Antineoplastic and Immunosuppressive Antibiotics chemical By performing these comparisons, we can account for the similarities and differences in the effects of the mechanisms acting on the surface and extract valuable insights into molecular binding to the substrate. The pillow effect, governing the lowering of the work function due to lying-down molecular tails in the striped low density phases, seems to have quite a similar contribution as the surface dipole effect emerging in the dense standing-up decanethiol phases. The dI/dz spectroscopy map of the nonoxidized β phase compared to the map of the oxidized λ phase indicates that the strong binding of molecules to the substrate is no longer present in the latter.Amorphous solid dispersions (ASDs) of class II and IV biopharmaceutics classification system drugs in water-miscible polymers are a well-recognized means of enhancing dissolution, while such dispersions in hydrophobic polymers form the basis of micro- and nanoparticulate technologies. However, drug recrystallization presents significant problems for product development, and the mechanisms and pathways involved are poorly understood. Here, we outline the use of combined differential scanning calorimetry (DSC)-synchrotron X-ray diffraction to monitor the sequential appearance of polymorphs of olanzapine (OLZ) when dispersed in a range of polymers. In a recent study (Cryst. Growth Des.2019,19, 2751-2757), we reported a new polymorph (form IV) of OLZ which crystallized from a spray-dried dispersion of OLZ in polyvinylpyrrolidone. Here, we extend our earlier study to explore OLZ dispersions in poly(lactide-co-glycolide) (PLGA), polylactide (PLA), and hydroxypropyl methyl cellulose acetate succinate (HPMCAS), with hic forms that may be produced by a single-drug molecule.Elaborate design of novel hybrid structures for hydrogen-evolution electrocatalysts is a crucial strategy for synergistically accelerating the reaction kinetics of water splitting. Herein, we prepare a three-dimensional (3D) sponge assembled by graphene nanocages (SGNCs) in which Ni nanoparticles and Ni single atoms coexist via a facile one-pot self-templating and self-catalytic strategy. Driven by simultaneous atomization and agglomeration under higher temperature, dual active sites of single atoms and nanoparticles are formed on graphene nanocages. Benefiting from the unique 3D porous structure and dual active sites, the SGNCs exhibit excellent hydrogen evolution reaction (HER) performance, which affords the current density of 10 mA cm-2 at a low overpotential of 27 mV. Theoretical calculations reveal that the interaction between single atoms and nanoparticles promotes HER kinetics. The controlled engineering strategy of non-noble metal-based hybrid materials provides prospects for innovative electrocatalyst development.A direct assembly of secondary benzylureas and related amine derivatives via copper-catalyzed carboamination of styrenes with potassium alkyltrifluoroborates and ureas, anilines, or an amide is reported. Terminal and 1,2-disubstituted alkenes, as well as dienes, participate in this three-component coupling reaction. The reaction mechanism likely involves the addition of an alkyl radical to the styrene, followed by metal-mediated oxidative coupling of the resulting benzylic radical with the amine derivative. Factors that impact substrate reactivity and regioselectivity are discussed.