Mchughlinde1710
The narrative of sustainable tourism transition in a context of adaptation to climate change is very relevant internationally. The availability and sharing of knowledge and information is a basic requirement for the successful planning of the tourism sector regarding this phenomenon. Planning adaptation in the urban tourism sector is widely regarded as a collectively-based process. However, collaborative planning is far from being the standard. This study reports the results of a Modified Delphi Approach (MDA) among experts about the future of urban tourism in a context of adaptation to climate change in Porto Metropolitan Area (Portugal), considering the outdoor thermal conditions perspective. Using an expert panel, the study gathered their opinions to analyze the degrees of responsibility of the main sectorial entities at different territorial levels, the conditions of action in the transformation agenda and the measures to be implemented in the adaptation and mitigation process - according to priority and sed on three axes (i) solutions based on the energy sector in the hotel industry (e.g., energy certification, prioritization of the use of renewable energy); (ii) improvement and expansion of green infrastructure for tourist enjoyment [e.g., creation of green areas (small additional pockets), namely in the center of Porto; and pedestrianization of central areas of the city] and (iii) network participation through the collaboration of various stakeholders with relevance in tourism and urban planning.The discharge of excessive phosphate from wastewater sources into the aquatic environment has been identified as a major environmental threat responsible for eutrophication. It has become essential to develop efficient but affordable techniques to remove excess phosphate from wastewater before discharging into freshwater bodies. Rhosin The use of metallic iron (Fe0) as a reactive agent for aqueous phosphate removal has received a wide attention. Fe0 in-situ generates positively charged iron corrosion products (FeCPs) at pH > 4.5, with high binding affinity for anionic phosphate. This study critically reviews the literature that focuses on the utilization of Fe0-based materials for aqueous phosphate removal. The fundamental science of aqueous iron corrosion and historical background of the application of Fe0 for phosphate removal are elucidated. The main mechanisms for phosphate removal are identified and extensively discussed based on the chemistry of the Fe0/H2O system. This critical evaluation confirms that the removal process is highly influenced by several operational factors including contact time, Fe0 type, influent geochemistry, initial phosphate concentration, mixing conditions, and pH value. The difficulty in comparing independent results owing to diverse experimental conditions is highlighted. Moreover, contemporary research in progress including Fe0/oxidant systems, nano-Fe0 application, Fe0 material selection, desorption studies, and proper design of Fe0-based systems for improved phosphate removal have been discussed. Finally, potential strategies to close the loop in Fe0-based phosphate remediation systems are discussed. This review presents a science-based guide to optimize the efficient design of Fe0-based systems for phosphate removal.Moss plays an important role in boreal forest ecosystems as an understory bryophyte species. Clearcut harvesting is a common boreal forest regeneration method that can expose understory vegetation to abiotic stressors impeding their recovery following post-harvest conditions. Very little is known concerning how moss remodel their chloroplast lipidome to enhance photosynthetic performance for successful acclimation to light and water stress during boreal forest regeneration following clearcut harvesting. The chloroplast lipidome and photosynthetic performance of Sphagnum sp. and three feathermoss species (Pleurozium schreberi, Hylocomium splendens, and Ptilium crista-castrensis) from a boreal black spruce (Picea mariana) forest were assessed using liquid chromatography-mass spectrometry (LC-MS), photospectrometry, and light response curves. We observed an overall increase in monogalactosyldiacylglycerol (MGDG) and sulfoquinovosyldiacylglycerol (SQDG) and decrease in digalactosyldiacylglycerol (DGDG) and phosphatidylglycerol (PG). In addition, unsaturation of the chloroplast lipidome occurred concomitant with photoprotection by carotenoid pigments to enhance the efficiency and photosynthetic capacity in moss exposed to light and water stress following clearcut harvesting. This appears to be a successful acclimation strategy used by moss to circumvent light stress during boreal forest regeneration following clearcut harvesting. These findings could be of significance in the development of boreal forest management strategies following resource harvesting.
The National Residency Matching Program is becoming more competitive across all medical specialties. The match rate for surgical specialties is considerably lower than the overall match rate each year. For those wishing to match into integrated plastic surgery, the magnitude of difficulty is in question.
Public data from 2016 to 2020 on the number of residency programs, number of residency positions, number of applicants, United States Medical Licensing Examination (USMLE) scores, and research experiences were collected for dermatology, categorical general surgery, neurological surgery, ophthalmology, orthopedic surgery, otolaryngology, integrated plastic surgery, integrated thoracic surgery, urology, and integrated vascular surgery.
In the 2020 Match, integrated plastic surgery had only 82 programs and 180 positions, and over the 2016-2020 Matches, the growth of integrated plastic surgery was a mere 6.9 positions per year. For matched 2020 applicants, integrated plastic surgery had the highest USMLE Step 1 score (249), highest USMLE Step 2 score (tied at 256), and second highest number of abstracts/presentations/publications (19.1).
The limited availability of residency spots in integrated plastic surgery, in conjunction with the quality of the applicant pool, makes it one of the most competitive matches. Candidates should understand this context before applying as to not risk going unmatched.
The limited availability of residency spots in integrated plastic surgery, in conjunction with the quality of the applicant pool, makes it one of the most competitive matches. Candidates should understand this context before applying as to not risk going unmatched.
Re-excision for positive margins (margins where tumor is positive) after breast conserving surgery (BCS) is common and burdensome for breast cancer patients. Routine shave margins can reduce positive margins and re-excision rates. Cavity shaving margin (CSM) removes margins from the lumpectomy cavity edges, whereas specimen shave margin (SSM) requires exvivo removal of margins from the resected specimen.
We assessed breast cancer patients undergoing BCS who received CSM or SSM procedures from 2017 to 2019. CSM and SSM techniques were compared by analyzing positive rates of primary and final shaved margins, re-excision rates, and tissue volumes removed.
Of 116 patients included in this study, 57 underwent CSM and 59 underwent SSM. Primary margins were positive or close in 19 CSM patients and 21 SSM patients (33% versus 36%; P=0.798). Seventeen CSM patients had a tumor in shaved margin specimens, compared to four patients for SSM (30% versus 7%; P<0.001); however, final shave margins were similar (5% versus 5%; P=0.983). Volumes of shave specimens were higher with SSM (40.7 versus 13.4cm
; P<0.001), but there was no significant difference in the total volume removed (146.8 versus 134.4cm
; P=0.540). For tumors 2cm or larger, the total volume removed (140 versus 206cm
; P=0.432) and rates of final margin positivity (7.5% versus 0%; P=0.684) were similar for both techniques.
CSM and SSM are effective techniques for achieving low re-excision rates. Our findings suggest that surgeons performing either CSM or SSM may maintain operative preferences and achieve similar results.
CSM and SSM are effective techniques for achieving low re-excision rates. Our findings suggest that surgeons performing either CSM or SSM may maintain operative preferences and achieve similar results.Hypercrosslinked pyrrole was synthesized via the Friedel-Crafts reaction and then carbonized to obtain urchin-like nitrogen-doped carbon (UNC). Ultrasmall iron oxide nanoparticles were then supported on UNC, and the composite was used to prepare an electrochemical sensor for detecting uric acid (UA) in human urine. FexOy/UNC was characterized and analyzed via scanning electron microscopy, transmission electron microscopy, energy dispersive spectrometry, X-ray diffraction, and X-ray photoelectron spectroscopy. A glassy carbon electrode (GCE) modified with FexOy/UNC was used as an electrochemical sensor to effectively identify UA. The electrochemical behavior of the FexOy/UNC-based UA sensor was studied using differential pulse stripping voltammetry, and the optimal conditions were determined by changing the amount of FexOy/UNC, pH of the buffer solution, deposition potential, and deposition time. Under optimal conditions, the FexOy/UNC-based electrochemical sensor detected UA in the range of 2-200 μM, where the limit of detection (LOD) for UA was 0.29 μM. Anti-interference experiments were performed, and the sensor was applied to the actual analysis of human urine samples. Urea, glucose, ascorbic acid, and many cations and anions present at 100-fold concentrations relative to UA did not strongly interfere with the response of the sensor to UA. The FexOy/UNC electrochemical sensor has high sensitivity and selectivity for uric acid in human urine samples and can be used for actual clinical testing of UA in urine.Age-related macular degeneration (AMD) is a common eye disease among the elderly in the Western world. AMD is a multifactorial disease, with a strong association with genetic variation in the complement system. One of the AMD-associated variants is the c.355G>A (p.Gly119Arg) variant in complement factor I (CFI), a central regulator of complement activation. Here, we report the generation of an iPSC line and its isogenic wildtype control derived from peripheral blood mononuclear cells of a female AMD-affected individual carrying the heterozygous variant c.355G>A (p.Gly119Arg). This line can be utilized to study the effects of this variant in disease-specific cell types.Long-QT syndrome type 2 (LQT2) is a life-threatening Mendelian disease caused by genetic variants in KCNH2. Herein, we generated a human embryonic stem cell line (WAe009-A-88) carrying a LQT2 related mutation in KCNH2, c.1720 A>G. The WAe009-A-88 line maintained stem cell-like morphology, expressed high levels of pluripotent markers, had a normal karyotype, and could differentiate into all three germ layers in vivo. The cell line can serve as valuable tools for modeling LQT2 in vitro and investigating the pathological mechanisms related to KCNH2 mutations.Becker muscular dystrophy (BMD), an X-linked recessive disorder caused of mutation in the dystrophin gene, is characterized by progressive muscle degeneration and proximal muscle weakness. We generated a human induced pluripotent stem cell (hiPSC) line from the fibroblasts isolated from patient with BMD by non-integrating reprogramming methods. The iPSC line highly expresses pluripotency markers, displays the normal karyotype and is able to differentiate into the three germ layers in vitro. The iPSC line will be a useful tool to study the pathogenesis of BMD and for drug screening.
