Mccallpaul1969
High-energy-density lithium (Li) metal batteries are severely hindered by the dendritic Li deposition dictated by non-uniform solid electrolyte interphase (SEI). Despite its unique advantages in improving the uniformity of Li deposition, the current anion-derived SEI is unsatisfactory under practical conditions. Herein regulating the electrolyte structure of anions by anion receptors was proposed to construct stable anion-derived SEI. Tris(pentafluorophenyl)borane (TPFPB) anion acceptors with electron-deficient boron atoms interact with bis(fluorosulfonyl)imide anions (FSI- ) and decrease the reduction stability of FSI- . Furthermore, the type of aggregate cluster of FSI- in electrolyte changes, FSI- interacting with more Li ions in the presence of TPFPB. Therefore, the decomposition of FSI- to form Li2 S is promoted, improving the stability of anion-derived SEI. In working Li | LiNi0.5 Co0.2 Mn0.3 O2 batteries under practical conditions, the anion-derived SEI with TPFPB undergoes 194 cycles compared with 98 cycles of routine anion-derived SEI. This work inspires a fresh ground to construct stable anion-derived SEI by manipulating the electrolyte structure of anions.
Atrial fibrillation (AF) is the most common persistent arrhythmia, and its complications include cerebral embolism, arterial embolism and heart failure. Some studies have found that homocysteine (HCY) is a new risk factor for AF. Currently, there is no meta-analysis to explore whether HCY is related to AF. Therefore, we conducted a meta-analysis to evaluate the relationship between HCY and AF, in order to draw the attention of clinicians to HCY.
To assess the association between HCY and AF, we conducted a meta-analysis of the literature on this topic to assess the strength of the evidence RESULTS The serum or plasma HCY levels was significantly associated with AF (WMD = 0.81, 95% CI 0.58 to 1.03; P < 0.001). In the analysis, there was a medium degree of heterogeneity (I
= 73%, P < 0.01). Sensitivity analysis showed that the main results remained unchanged after omitting any single study or converting the random effects model (REM) to fixed effects model (FEM). Subgroup analyses indicated age, body mass index, race, diabetes, systolic blood pressure, triglycerides, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol maybe causes of heterogeneity.
The meta-analysis showed that there is a significant correlation between HCY and AF and the role of HCY in AF patients should not be ignored in clinical.
The meta-analysis showed that there is a significant correlation between HCY and AF and the role of HCY in AF patients should not be ignored in clinical.
Several functional imaging techniques, including monoexponential diffusion-weighted imaging (m-DWI), intravoxel incoherent motion (IVIM), and diffusion kurtosis (DK) imaging, have been used in differentiating benign and malignant musculoskeletal tumors. Combining all three techniques in the same study population may improve differentiation.
To compare the diagnostic performance of m-DWI, IVIM, and DK models and their combinations in differentiating benign and malignant musculoskeletal tumors.
Prospective.
Fifty patients with benign and malignant musculoskeletal tumors divided into nonmyxoid and nonchondroid and myxoid and/or chondroid subgroups.
A 1.5 T/m-DWI, IVIM, and DK single-shot spin-echo echo-planar sequences.
Minimum and volumetric values of apparent diffusion coefficient (ADC), pure molecular diffusion (D
), pseudodiffusion (D*), perfusion fraction (f), diffusion coefficient for kurtosis model (D
), and Kurtosis (K) were compared between all benign and malignant tumors. Subgroup analys can be used to differentiate benign and malignant musculoskeletal tumors. Our findings suggest that the added value of multiparametric approach in such differentiation is not significant.
1 TECHNICAL EFFICACY Stage 2.
1 TECHNICAL EFFICACY Stage 2.Therapeutics that promote oligodendrocyte survival and remyelination are needed to restore neurological function in demyelinating diseases. Sphingosine 1-phosphate (S1P) is an essential lipid metabolite that signals through five G-protein coupled receptors. S1P receptor agonists such as Fingolimod are valuable immunosuppressants used to treat multiple sclerosis, and promote oligodendrocyte survival. However, the role for endogenous S1P, synthesized by the enzyme sphingosine kinase 2 (SphK2), in oligodendrocyte survival and myelination has not been established. This study investigated the requirement for SphK2 in oligodendrocyte survival and remyelination using the cuprizone mouse model of acute demyelination, followed by spontaneous remyelination. Oligodendrocyte density did not differ between untreated wild-type (WT) and SphK2 knockout (SphK2-/- ) mice. However, cuprizone treatment caused significantly greater loss of mature oligodendrocytes in SphK2-/- compared to WT mice. Following cuprizone withdrawal, spontaneous remyelination occurred in WT but not SphK2-/- mice, even though progenitor and mature oligodendrocyte density increased in both genotypes. Levels of cytotoxic sphingosine and ceramide were higher in the corpus callosum of SphK2-/- mice, and in contrast to WT mice, did not decline following cuprizone withdrawal in SphK2-/- mice. We also observed a significant reduction in myelin thickness with aging in SphK2-/- compared to WT mice. These results provide the first evidence that SphK2, the dominant enzyme catalyzing S1P synthesis in the adult brain, is essential for remyelination following a demyelinating insult and myelin maintenance with aging. We propose that persistently high levels of sphingosine and ceramide, a direct consequence of SphK2 deficiency, may block remyelination.
Studies examining the effect of biased cognitions on later pain outcomes have primarily focused on attentional biases, leaving the role of interpretation biases largely unexplored. Also, few studies have examined pain-related cognitive biases in elderly persons. The current study aims to fill these research gaps.
Younger and older adults with and without chronic pain (N=126) completed an interpretation bias task and a free-viewing task of injury and neutral scenes at baseline. Participants' pain intensity and disability were assessed at baseline and at a 6-month follow-up. A machine-learning data-driven approach to analysing eye movement data was adopted.
Eye movement analyses revealed two common attentional pattern subgroups for scene-viewing an "explorative" group and a "focused" group. At baseline, participants with chronic pain endorsed more injury-/illness-related interpretations compared to pain-free controls, but they did not differ in eye movements on scene images. Older adults interpreted illnewards pain.
Adults with chronic pain endorsed more injury-/illness-related interpretations than pain-free controls. Older adults endorsed more illness interpretations than younger adults. A more negative interpretation bias indirectly predicted pain disability 6 months later through hypervigilance towards pain.Activation of estrogen receptors is thought to modulate cognitive function in the hippocampus, prefrontal cortex, and striatum by affecting both excitatory and inhibitory synaptic transmission. The entorhinal cortex is a major source of cortical sensory and associational input to the hippocampus, but it is unclear whether either estrogens or progestogens may modulate cognitive function through effects on synaptic transmission in the entorhinal cortex. This study assessed the effects of the brief application of either 17-β estradiol (E2) or progesterone on excitatory glutamatergic synaptic transmission in the female rat entorhinal cortex in vitro. Rats were ovariectomized on postnatal day (PD) 63 and also received subdermal E2 implants to maintain constant low levels of circulating E2 on par with estrus. Electrophysiological recordings from brain slices were obtained between PD70 and PD86, and field excitatory postsynaptic potentials (fEPSPs) reflecting the activation of the superficial layers of the entorhinal cortex were evoked by the stimulation of layer I afferents. The application of E2 (10 nM) for 20 min resulted in a small increase in the amplitude of fEPSPs that reversed during the 30-min washout period. The application of the ERα agonist propylpyrazoletriol (PPT) (100 nM) or the β agonist DPN (1 μM) did not significantly affect synaptic responses. However, the application of the G protein-coupled estrogen receptor-1 (GPER1) agonist G1 (100 nM) induced a reversible increase in fEPSP amplitude similar to that induced by E2. Furthermore, the potentiation of responses induced by G1 was blocked by the GPER1 antagonist G15 (1 μM). Application of progesterone (100 nM) or its metabolite allopregnanolone (1 μM) did not significantly affect synaptic responses. The potentiation of synaptic transmission in the entorhinal cortex induced by the activation of GPER1 receptors may contribute to the modulation of cognitive function in female rats.
Placebo hypoalgesia can be induced by observing a person (model) whose pain relief is the result of the use of an inert substance or procedure. This study examined whether verbal modelling, that is, showing pain ratings provided by other people, is sufficient to induce placebo hypoalgesia.
Participants from the experimental groups were acquainted with pain ratings (presented on VASs) derived from a single person (groups 1 and 3) or a group of people (groups 2 and 4) that were allegedly subjected to the same painful procedure. The ratings of pain stimuli that were allegedly applied with placebo were lower than the ratings of stimuli applied without placebo. In two of the experimental groups (group 3 and 4), participants also watched a video recording showing individuals who allegedly provided pain ratings; however, they did not observe them undergoing pain stimulation. The control group did not undergo any manipulation. Then, the participants received a series of the same thermal pain stimuli that were appficient to induce placebo hypoalgesia; thus, neither direct nor indirect observation of a person experiencing pain is necessary to induce this effect. Pain ratings derived from a group of people can decrease pain sensations but they do not produce placebo hypoalgesia.
Patient engagement in care is a priority and a key component of clinical practice. find more Different approaches to care have been introduced to foster patient engagement. There is a lack of a recent review on tools for assessing the main concepts and dimensions related to patient engagement in care.
Our scoping review sought to map and summarize recently validated tools for assessing various concepts and dimensions of patient engagement in care.
A scoping review of recent peer-reviewed articles describing tools that assess preferences in and experience with patient engagement in care was conducted in four databases (Ovid Medline, Ovid EMBASE, Cochrane Database of Systematic Reviews, CINAHL-EBSCO). We adopted a broad definition based on the main concepts of patient engagement in care patient-centredness, empowerment, shared decision-making and partnership in care.
Of 2161 articles found, 16, each describing a different tool, were included and analysed. Shared decision-making and patient-centredness are the two main concepts evaluated, often simultaneously in most of the tools.
