Mccainegholm8327

Optimal time between neoadjuvant radio-chemotherapy period and surgery remains controversial in patients with rectal cancer an increasing number of studies show results in favour of a long interval.

We conducted a retrospective analysis of the cases of low-middle rectal adenocarcinoma undergoing neoadjuvant RT-CT and surgery the primary endpoint was the complete pathological response rate and the secondary endpoint the rate of complications. We analysed cases from 1/01/2003 to 31/12/2018 divided in two periods from 2003 to 2010 (23 pts) and from 2011 to 2018 (23 pts). The two periods were characterised by two different surgical teams which use different time intervals (≤vs>8 weeks).

The pCR rate is 21.7% in both groups; as regards the complications, the difference between the two groups is in grade IIIb 8.7% in the first group and 17.4% in the second group (p 0.66).

Although our study is based on a small number of patients, it shows the same rate of pCR with respect to two different time intervals; this suggests the need for studies based on the division of patients into subgroups and the evaluation of different time intervals in order to reach the best oncological outcomes.

Although our study is based on a small number of patients, it shows the same rate of pCR with respect to two different time intervals; this suggests the need for studies based on the division of patients into subgroups and the evaluation of different time intervals in order to reach the best oncological outcomes.

Chronic obstructive pulmonary disease (COPD) is associated with a high incidence of postoperative pulmonary complications (PPCs). When untreated COPD is found before lung cancer surgery, we have been actively intervening therapeutically with inhaled long-acting muscarinic antagonist (LAMA)/long-acting β2-agonist (LABA) combinations. We investigated the efficacy of preoperative LAMA/LABA treatment.

We reviewed data from 261 patients who underwent pulmonary resection for primary lung cancer. Of these, 59 patients showed unrecognized obstructive ventilatory impairment on respiratory function testing. We administered inhaled drugs for 38 patients, of whom 22 patients treated with LAMA/LABA combinations and diagnosed with COPD were retrospectively analyzed regarding improvement of respiratory function and postoperative course.

Median duration of LAMA/LABA treatment was 19.5 days (interquartile range (IQR), 10.5-28.3 days). Percentage predicted vital capacity (%VC) (pretreatment 95.6%, IQR 91.9-111.7 vs posttven COPD patients diagnosed on preoperative screening to experience the same frequency of PPCs as previously treated patients.

Although minimally invasive techniques are currently recognized as effective and validated treatment for small gastric gastrointestinal stromal tumors (GISTs), the role of laparoscopy is not yet established. The aim of this study was to evaluate the outcomes of laparoscopic treatment of gastric GISTs compared to the results obtained in a group of patients treated with conventional surgery.

A retrospective analysis was performed, using a prospectively maintained comprehensive database of 100 patients treated for gastric GIST in the period from 2000 to 2015. Thirty-six patients were treated laparoscopically and 64 patients underwent conventional surgery. The analyzed medical data included clinical and pathological features of removed tumors, perioperative parameters as well as short and long-term results of surgical treatment.

Histopathological examination confirmed radical resection for all patients. No deaths were reported in the 90-day post-operative period. Adavosertib ic50 Patients in laparoscopic group had significantly shorter length of hospital stay (5.5 vs. 7 days, p<0.0001), fewer extended and combined surgical procedures (11.2% vs 34.4% and 2.8% vs 39%; p=0.02 and p<0.001, respectively), and a smaller tumor size compared to laparotomic group (3 vs 6 cm, p<0.0001). The median post-operative follow-up for the entire study population was 42 months. During this period, 11 patients died and 4 of them developed a tumor recurrence. None of them was in the laparoscopic group.

Laparoscopy in the treatment of gastric GISTs has unquestionable advantages, but its choice is strictly related to tumor features.

Laparoscopy in the treatment of gastric GISTs has unquestionable advantages, but its choice is strictly related to tumor features.

In early 2020, the novel coronavirus infection (COVID-19) spread rapidly throughout the whole world, causing a massive response in terms of health resource disposal. Moreover, lockdowns were imposed in entire countries. This study aims to assess whether there was a downward trend in emergency general surgery (EGS) procedures accomplished throughout the COVID-19 pandemic and to determine patients' and diseases' characteristics.

This is a multicentric retrospective observational cohort analysis conducted on patients who underwent EGS procedures during the lockdown and the same period of the previous year in the three Third Level Hospitals of Friuli Venezia Giulia, Italy.

During the study period, 138 patients underwent EGS procedures versus the 197 patients operated on in 2019, meaning a 30.0% decrease in the number of surgeries performed. The incidence rate for EGS procedures was 2.5 surgeries per day during the COVID-19 pandemic compared to 3.5 surgeries per day in 2019 (P<0.001). The characteristics of patients operated on in 2020 were comparable to those of patients who underwent EGS in 2019, except for the higher prevalence of male patients during the COVID-19 pandemic (76.8 vs. 55.8; P<0.001). No difference was recorded in disease severity between the two study periods.

During the COVID-19 pandemic, a significant reduction in EGS procedures carried out was recorded. However, no clear explanation can be given to elucidate this fact.

During the COVID-19 pandemic, a significant reduction in EGS procedures carried out was recorded. However, no clear explanation can be given to elucidate this fact.

This prospective observational study aims to assess the association between maternal abdominal subcutaneous and visceral fat thickness measured with ultrasound scan during the first trimester and the risk of developing gestational diabetes mellitus (GDM).

We recruited 43 non-diabetic women with singleton pregnancy between 11 and 14 weeks' gestation and evaluated ultrasonographic measurements of subcutaneous fat thickness (SFT) and preperitoneal fat (PF) above the umbilicus. During 2nd trimester, GDM screening was performed by 75g two-hour oral glucose tolerance test (OGTT) and diagnosis was made when one or more plasma glucose values meets or exceeds the values indicated by International Association of the Diabetes and Pregnancy Study Groups (IADPSG).

Among the 43 woman, 8 developed GDM (18.6%). Of these 37,5% (n=3) had been diagnosed with GDM during a previous pregnancy, with a statistically significant correlation (p = 0.035). Mean SFT for all patients was significantly higher in the GDM group compared to non GDM group (27.