Macphersonhuang0488
SAM sensor-Samtor-overexpression in C2C12 cells could displace mTORC1 from lysosome thereby inhibiting the mTORC1 signaling. Addition of betaine attenuates this inhibition by increasing SAM level and then disrupting interaction of Samtor complex.
These observations indicate that betaine could promisingly promote protein synthesis to delay age-related muscle loss.
These observations indicate that betaine could promisingly promote protein synthesis to delay age-related muscle loss.Understanding the balance between supply and demand of ecosystem services (ESs) is helpful for sustainable urban management. However, the interactions among multiple ESs supplies and demands remain under-researched, and ESs supply and demand spatial heterogeneity and correlation characteristics at the city level are rarely studied, especially in arid areas. To fill this gap, we established a comprehensive assessment framework of ESs supply and demand through integrating multi-source remote sensing data, social economy, and policy objectives, for the oasis city of Urumqi, China. The ESs supply-demand mismatches were revealed at the city level, and the spatial relationship between the ESs supply and demand was analyzed using spatial statistics. The results demonstrated that (1) The total quantity of supply and demand of food provision, carbon sequestration, PM10 removal, and recreation services in Urumqi revealed that the demand was greater than the supply, the deficits being 16.10 × 107 kcal/ha, 6.88 × 104 t/ha, 155.86 kg/ha, and 697.26, respectively. (2) The supply and demand assessment of ESs revealed spatial differences from the city center to the suburbs, which further indicated that there are neighborhood similarities between the supply and demand of ESs. (3) The matching types of ESs supply and demand present obvious spatial heterogeneity, which can be divided into four types High-high, high-low, low-high, and low-low. Owing to rapid urban development in the inner city, the city center is dominated by low-high, whereas the urban-rural ecotone is characterized by high-low, owing to the higher elevation and water resource advantages in the suburbs. Based on the analysis of the supply, demand, and matching of ESs, economic development and sustainable management policies are proposed for different ecological spaces. Integr Environ Assess Manag 2021;001-12. © 2021 SETAC.
To evaluate healing response at strut-level and cross-section level after implanting an ultra-thin strut, everolimus-eluting stent with biodegradable polymer (Tetrilimus) using optical coherence tomography (OCT) at 3 and 6months.
This was prospective, multi-centre, single-arm, and investigator-initiated study performed at seven Indian sites between January, 2017 and September, 2018. OCT evaluations were performed in 57 patients who underwent Tetrilimus stent implantation. Follow-up OCT was scheduled at 3months for first 16 patients and at 6months for 41 patients. Primary outcomes included degree of strut coverage, malapposition and thickness of neointimal hyperplasia (NIH) over covered struts.
Sixty one Tetrilimus stents were implanted to treat 59 lesions in 57 patients. Selleckchem Tanzisertib Paired (baseline and follow-up) OCT data was available for 12 patients and 30 patients at 3 and 6months, respectively. At 3months, rapid early healing was indicated by 95.48% covered struts per lesion with very low (0.11 ± 0.06 mm) NIH.here was no difference in vascular healing and eccentricity after implantation of the Tetrilimus stents with smaller and larger diameters.
The treatment of food with ultraviolet-B (UV-B) light to increase the vitamin D content is accompanied by the formation of photoisomers, such as lumisterol
. The physiological impact of photoisomers is largely unknown.
Three groups of C57Bl/6 mice are fed diets containing 50µg kg
deuterated vitamin D
with 0, 50 (moderate-dose) or 2000µg kg
(high-dose) lumisterol
for four weeks. Considerable quantities of lumisterol
and vitamin D
are found in the plasma and tissues of mice fed with 2000µg kg
lumisterol
but not in those fed 0 or 50µg kg
lumisterol
. Mice fed with 2000µg kg
lumisterol
showed strongly reduced deuterated 25-hydroxyvitamin D
(-50%) and calcitriol (-80%) levels in plasma, accompanied by downregulated mRNA abundance of cytochrom P450 (Cyp)27b1 and upregulated Cyp24a1 in the kidneys. Increased tissue levels of vitamin D
were also seen in mice in a second study that are kept on a diet with 0.2% UV-B exposed yeast versus those fed 0.2% untreated yeast containing iso-amounts of vitamin D
.
High doses of lumisterol
can enter the body, induce the formation of vitamin D
, reduce the levels of 25(OH)D
and calcitriol and strongly impact the expression of genes involved in the degradation and synthesis of bioactive vitamin D.
High doses of lumisterol2 can enter the body, induce the formation of vitamin D2 , reduce the levels of 25(OH)D3 and calcitriol and strongly impact the expression of genes involved in the degradation and synthesis of bioactive vitamin D.
Children with cancer diagnosis are overall at a higher risk of thrombosis. For a newly diagnosed blood clot, patients are commonly started on anticoagulants to prevent further extension and embolization of the clot. In the rare instance that a pediatric patient has a tumor thrombus, role of anticoagulation is less clear.
Patients under 21years of age with a finding of tumor thrombus on imaging from 2010 to 2020 at Texas Children's Hospital were identified and their medical records were reviewed.
A total of 50 patients were identified. Most thrombi were incidental findings at diagnosis; however, two patients presented with pulmonary embolism (PE). Inferior vena cava extension was noted in 36% of the patients, and 24% patients had an intracardiac tumor thrombus. Anticoagulation was initiated in 10 patients (20%). There was no difference in the rate of bland thrombus formation and/or embolization in patients who did or did not receive anticoagulation. However, three of the six patients with asymptomatic tuto support routine initiation of anticoagulation in pediatric patients with intravascular extension of solid tumors.
Boron is a trace element that naturally occurs in soil, making mineral and medicinal water important contributors to overall intake. Thus, in a systematic screening, the mean boron concentrations of 381 German mineral and medicinal waters are determined.
Boron concentrations in mineral and medicinal waters are analyzed by inductively coupled mass spectrometry (ICP-MS). Highest boron values find in waters from the southwest of Germany. The boron content of the waters is positively correlated with the concentration of most other analyzed bulk elements, including calcium, potassium, magnesium, and sodium. Mineral waters with either low (7.9µg L
), medium (113.9µg L
), or high (2193.3µg L
) boron content are chosen for boron exposure experiments in fruit flies (Drosophila melanogaster) and humans. In flies, boron-rich mineral water significantly increases boron accumulation, with the accumulation predominantly occurring in the exoskeleton. In humans, serum boron and 24-h urinary boron excretion significantly increase only in response to the intake of boron-rich mineral water.
Overall, the current data demonstrate that mineral and medicinal waters vary substantially in the content of boron and that boron-rich mineral water can be used to elevate the boron status, both in flies and humans.
Overall, the current data demonstrate that mineral and medicinal waters vary substantially in the content of boron and that boron-rich mineral water can be used to elevate the boron status, both in flies and humans.
Cleft lip with/without cleft palate and cleft palate only is congenital birth defects where the upper lip and/or palate fail to fuse properly during embryonic facial development. Affecting ~1.2/1000live births worldwide, these orofacial clefts impose significant social and financial burdens on affected individuals and their families. Orofacial clefts have a complex etiology resulting from genetic variants combined with environmental covariates. Recent genome-wide association studies and whole-exome sequencing for orofacial clefts identified significant genetic associations and variants in several genes. Of these, we investigated the role of common/rare variants in SHH, RORA, MRPL53, ACVR1, and GDF11.
We sequenced these five genes in 1255 multi-ethnic cleft lip with/without palate and cleft palate only samples in order to find variants that may provide potential explanations for the missing heritability of orofacial clefts. Rare and novel variants were further analyzed using in silico predictive tools.
Ninteen total variants of interest were found, with variant types including stop-gain, missense, synonymous, intronic, and splice-site variants. Of these, 3 novel missense variants were found, one in SHH, one in RORA, and one in GDF11.
This study provides evidence that variants in SHH, RORA, MRPL53, ACVR1, and GDF11 may contribute to risk of orofacial clefts in various populations.
This study provides evidence that variants in SHH, RORA, MRPL53, ACVR1, and GDF11 may contribute to risk of orofacial clefts in various populations.
Nutritional deficiencies in children with cancer at time of diagnosis and during treatment may negatively affect disease outcome and increase treatment-related toxicity. Yet zinc, an essential nutrient important for supporting immune function and known for reducing diarrheal episodes, is rarely assessed in these children.
Fifty children (1month to 18years) with recently diagnosed cancer were enrolled in this study. An age and gender matched control group (n=50) was also recruited. Plasma and urinary zinc, plasma copper, and C-reactive protein (CRP) levels were measured at baseline, 3, and 6months following diagnosis. A retrospective review of the toxicity profile was performed in the cohort of children with cancer for the first 4years after initial diagnosis.
CRP and plasma copper (both acute-phase reactants) were elevated in patients with cancer compared to controls at baseline, both p<.03. Plasma zinc levels were not significantly different from controls at baseline, but decreased by 11% in the cancer group over 6months of treatment, 83.2±15.6 to 74.3±14.8μg/dl, p=.01. Plasma zinc dropped to deficient levels in 35% of cases over the initial 6months. Zinc deficiency at 6months was related to an increased incidence of severe diarrhea during 4years of follow-up, p<.001.
Zinc deficiency is an underrecognized problem among patients undergoing treatment for cancer and is associated with severe diarrhea. Further studies are needed to evaluate causes for zinc deficiency, related effects, and a possible role for zinc supplementation.
Zinc deficiency is an underrecognized problem among patients undergoing treatment for cancer and is associated with severe diarrhea. Further studies are needed to evaluate causes for zinc deficiency, related effects, and a possible role for zinc supplementation.Trisomy 16 is the most common autosomal trisomy in humans, which is almost uniformly embryonic lethal. Partial trisomy 16 including a segment of the long arm of chromosome 16 is occasionally compatible with life and has been associated with severe congenital defects, growth retardation, and early lethality. Segmental trisomy of 16q is usually described concomitantly with partial monosomy of another chromosome, often resulting from a parental balanced translocation. Pure partial chromosome 16q trisomy is exceedingly rare. About nine children with 16q12→qter and 16q13→qter duplication have been reported in the literature, almost all described with monosomy of a second chromosome, and highlighting very few long-term survivors. A single individual with pure partial distal 16q12.1q23.3 duplication has been reported in an infant, underscoring complexities of genetic counseling and management, especially in view of life-limiting congenital anomalies in rare survivors. Here, we present a 12-month-old child with pure 16q12.
