Lundgreenfernandez1915

The prediction model that assumed health behaviors observed at T1 continued to T2 reasonably predicted changes in lung cancer risk. This prediction model and the identified baseline risk factors can identify screen-ineligible participants who should be closely followed for future eligibility.Taking a cue from remarks Thomas Kuhn makes in 1990 about the historical turn in philosophy of science, I examine the history of history and philosophy of science within parts of the British philosophical context in the 1950s and early 1960s. During this time, ordinary language philosophy's influence was at its peak. I argue that the ordinary language philosophers' methodological recommendation to analyze actual linguistic practice influences several prominent criticisms of the deductive-nomological model of scientific explanation and that these criticisms relate to the historical turn in philosophy of science. To show these connections, I primarily examine the work of Stephen Toulmin, who taught at Oxford from 1949 to 1954, and Michael Scriven, who completed a dissertation on explanation under Gilbert Ryle and R.B. Braithwaite in 1956. I also consider Mary Hesse's appeal to an ordinary language-influenced account of meaning in her account of the role of models and analogies in scientific reasoning, and W.H. Watson's Wittgensteinian philosophy of science, an early influence on Toulmin. I think there are two upshots to my historical sketch. First, it fills out details of the move away from logical positivism to more historical- and practice-focused philosophies of science. Second, questions about linguistic meaning and the proper targets and aims of philosophical analysis are part and parcel of the historical turn, as well as its reception. Looking at the philosophical background during which so-called linguistic philosophers also had a hand in bringing these questions to prominence helps us understand why.The results of the first detailed study, involving a large number of samples, on water equivalent factor (WEQp), non-exchangeable organically bound tritium (NE-OBT) and tissue free water tritium (TFWT) activity concentrations in predominant plant species of the tropical monsoonal climatic region, are presented. A total of 369 samples from the vicinity of the PHWR nuclear power plant (NPP) at Kaiga, West Coast of India, and 47 samples of the control region (region not affected by local anthropogenic sources) were analysed. The WEQp varied in the range of 0.347-0.666 L kg-1 with an overall mean value of 0.540 ± 0.045 L kg-1. The NE-OBT activity concentration varied in the range of less then 9.8-60.9 Bq L-1 of combustion water (mean = 24.6 ± 11.5 Bq L-1) and that of TFWT in the range of 9.2-60.5 Bq L-1 (mean = 30.7 ± 10.9 Bq L-1) in the vicinity of the NPP. Rigorous statistical analysis of the data confirmed that (i) the activity concentrations of both forms of tritium decreased with the increase in the distance between the sampling location and NPP, and beyond 10 km, it was similar to that of the control region, (ii) the incorporation of tritium released from the NPP into wild plant leaves is not species-dependent, (iii) the NE-OBT activity concentration in the 5-10 km zone exhibited a dependence on the prevailing wind regime with respect to the NPP, but not in the 2.3-5 km zone which suggests that the transport of tritium, released into the atmosphere as the gaseous effluent, through diffusion is a dominating factor governing its activity concentration in the 2.3-5 km zone. The NE-OBT to TFWT specific activity concentration ratio (R-value) had a mean value of 0.82 ± 0.27 (range 0.38-1.64) for samples collected from the vicinity of the NPP and 1.93 ± 0.50 (range 1.35-3.19) for the control region. Recording higher NE-OBT activity concentration and R-value at the control region highlights the necessity of detailed studies to understand the mechanism of NE-OBT partitioning in the terrestrial environment.

Responding to legal medically assisted dying requests may become the most frequent form of nurses' participation in that service. Recent research has explored nurses' discrete responses to requests about or for assisted dying; however, nurses likely hold intentions for multiple responses to these requests. These intentions form patterns shaped by individual factors such as attitude and beliefs. No research has investigated patterns of multiple responses to requests for assisted dying, how these patterns form profiles of nurses and factors that might explain these response profiles.

Identify patterns of multiple responses that nurses intend for requests for assisted dying. Verteporfin ic50 Explore how these patterns form profiles of nurses' who share similar patterns of intended responses. Finally, investigate how attitude, norms and beliefs distinguish response profiles.

Cross-sectional survey SETTINGS Online survey of Australian nurses PARTICIPANTS 365 experienced registered nurses (years in nursing mean=23, SD=14.21) iple responses. These profiles represent different types and levels of engagement with requests. Further, attitude and social expectations distinguish profiles with stronger intentions to engage positively. Using a cluster analysis methodology provides a more holistic understanding of nurses' intended responses to assisted dying requests by focusing on various responses and demonstrating that nurses have distinctive patterns of responses.

Nurses intended responses have been usefully constructed as five patterns or profiles of multiple responses. These profiles represent different types and levels of engagement with requests. Further, attitude and social expectations distinguish profiles with stronger intentions to engage positively. Using a cluster analysis methodology provides a more holistic understanding of nurses' intended responses to assisted dying requests by focusing on various responses and demonstrating that nurses have distinctive patterns of responses.Vascular endothelial growth factor (VEGF) is one of the most important regulators of angiogenesis. Several single nucleotide polymorphisms (SNPs) are associated with the VEGF overexpression and tumor progression in several cancers. This study aimed to determine the association of VEGF rs833061 and rs2010963 polymorphism and their haplotypes with susceptibility to colorectal cancer (CRC) in the Iranian population. A total of 284 colorectal cancer patients (37.3% women, 62.7% men) were enrolled in this study. Healthy controls without evidence of cancer history or family cancer predispositions were frequency-matched to the cases by sex and age (± 5 years). Genotyping was performed by the Sequenom mass ARRAY method and the genotype distribution and risk estimate were analyzed by SPSS software. The correlation between the genotypes and clinicopathological parameters (Dukes stage, phenotype, location, differentiation, and tumor size) among colorectal cancer patients were investigated. We found a significant relationship, between rs833061T/C genotype and their TG haplotype with the age of diagnosis less then 60; (p = 0.012, p = 0.014) and rs2010963G/C genotype with female gender and TG haplotype with third and fourth tumor stage and tumor location (p = 0.04and p = 0.047). This study showed that rs833061T/C genotype and TG haplotype increase the susceptibility to colon cancer in the Iranian population. This susceptibility has a significant relationship with the age of diagnosis and different stages of the tumor.

despite advances in blood glucose control, the incidence of sight loss has not decreased in patients with diabetes. Several growth factors have been suggested as factors associated with diabetic retinopathy pathogenesis. In the current cross-sectional study, we examined the relationship between FGF21 and retinopathy as a microvascular complication of diabetes.

Adult patients with type 2 diabetes mellitus (T2DM); were recruited and evaluated for retinopathy. Different clinical and biochemical factors, such as FGF21 were assessed and compared between groups.

91 T2DM patients with retinopathy, 93 T2DM patients without retinopathy, and 86 healthy control subjects were recruited. FGF21 was significantly different between the three groups (P<0.001). In the multivariate logistic regression model obesity, cholesterol, HbA1c, and FGF21 were associated with diabetic retinopathy. ROC curve analysis was used for establishing a cut-off FGF21 concentration to predict diabetic retinopathy. The area under the curve in this model was 0.992. The best cut-off point for predicting retinopathy based on FGF21 was greater than 312pg/ml, with a sensitivity of 97.80% and specificity of 96.77%.

FGF21 was associated with diabetic retinopathy and can be suggested as a surrogate diagnostic marker in the diagnosis of this state.

FGF21 was associated with diabetic retinopathy and can be suggested as a surrogate diagnostic marker in the diagnosis of this state.

Smartphone applications (e.g., Google Fit) may be a good alternative tool for accelerometers in estimating energy expenditure of physical activities because they are affordable, easy to use, and freely downloadable on smartphones. We aimed to determine the concurrent validity of the Fibion and Google Fit for measuring energy expenditure of functional tasks in healthy individuals.

In this cross-sectional study, 28 healthy individuals (21.25±1.84 years) performed certain tasks (lying, standing, 6-min walk test, treadmill walking, stair climbing and cycling) for ∼90min, while wearing a Fibion accelerometer on their thigh and having the Google Fit application in a smartphone placed in their trouser pocket. Concurrent validity between the energy expenditure data of the Google Fit and Fibion was assessed using the Spearman rho correlation coefficient (data were not normally distributed), Bland-Altman plots and linear regression.

Neither energy expenditure for the whole duration nor for the tasks, except sitting+treadmill walking (r=0.419, p=0.027), showed significant correlations between the Google Fit and Fibion measurements. A proportional bias was evident for almost all comparisons.

The Google Fit did not provide valid energy expenditure measurements compared to the Fibion for most of the investigated tasks in healthy individuals.

The Google Fit did not provide valid energy expenditure measurements compared to the Fibion for most of the investigated tasks in healthy individuals.Phthalic acid esters (PAEs) are predominant hazardous substances and endocrine-disrupting compounds to be controlled in soil. The degradation behaviors of PAEs in soil had been long term concerned. Thus, the degradation rate (K) is important for assessing theexposure risk and is of great significance in evaluating the ecological risk of PAEs in soil environment. But by far, quantitative structure activity relationship (QSAR) models for PAEs degradation have rarely been considered in soil environment. In this study, quantum chemical parameters were considered along with soil properties as two kinds of descriptors in QSAR model. A total of 32 logk of PAEs were collected from reference and experiment. Degradation kinetics in soils were determined by pseudo-first order kinetic models. The residual concentration of PAEs in Udic ferrosols and Aquic cambisols suggesting a potential expose risks of PAEs to ecosystem in soil. The QSAR model between logk and quantum chemical parameters revealed that EHOMO and qC- are two predominant factors in determining logk value.