Lowedoherty3020

Other studies are needed to confirm our results.

Our data furtherly support peptide receptor radionuclide therapy as a safe and effective treatment of patients affected by pulmonary neuroendocrine neoplasms allowing disease control in about 71% of patients without showing significant toxicity. Other studies are needed to confirm our results.

The goal of our retrospective single tertiary academic medical center investigation was to examine the added diagnostic value and clinical impact of

Ga-DOTATATE PET/CT in the therapeutic management of patients with neuroendocrine tumors (NETs).

Imaging database was queried for all "PET-DOTATATE" examinations performed at our tertiary care academic institution using MONTAGE™. The patient's clinical history and recent prior imaging were reviewed. The additional diagnostic value and clinical management impact of

Ga-DOTATATE were assessed through retrospective chart review.

A total of 81

Ga-DOTATATE PET/CT scans in 74 patients were found, and 11 patients were excluded from analysis as they had no prior imaging available for comparison, with resultant analysis cohort of 63 patients. Six patients had 2 or more

Ga-DOTATATE PET/CT examinations. The most common primary diagnosis was undifferentiated NET (63.5%), followed by carcinoid (27.0%), paraganglioma (4.8%), insulinoma (3.2%), and pheochromocytoma h NET.

Our retrospective cohort demonstrated that 68Ga-DOTATATE PET/CT improves lesion detection over conventional imaging in 33.3% and impacts the therapeutic management in 23.8% of patients with NET.

The aim of this study was to determine the influence of H2RAs to the 24-h I-131 uptake in the thyroid gland.

A prospective study with quasi-experimental pre- and post-study design was done. Subjects with normal fT4 level who fulfilled the inclusion criteria were selected. All subjects received 0.2mCi of I-131 orally, and the thyroid uptake calculations were performed at 24h later. The same procedure was performed 4weeks later. All of the subjects were asked to consume H2RAs 1h before the administration of I-131 of the second procedure. Both 24-h thyroid uptakes were statistically analysed.

A total of 14 subjects were enrolled in this study. Most of them were women (78%) with an average age of 37.6years old (range 20-55). This study showed a median of 24-h thyroid uptake of I-131 before and after H2-receptor antagonist of 20.6% (range 11.1-57.8%) and 16.7% (range 8.1-39.4%) respectively.

H2-receptor antagonist caused a significance reduction of 24-h I-131 uptake value in the thyroid gland.

H2-receptor antagonist caused a significance reduction of 24-h I-131 uptake value in the thyroid gland.

To compare

I-therapy outcomes in high turnover and normal turnover Graves' disease patients and predict optimal first

I activity for high turnover patients.

Retrospective cohort design (12) validated by propensity score analysis. Cohort 1, high turnover (2-h RAIU/24-h RAIU ≥ 1),

 = 104, and cohort 2, normal turnover (ratio < 1),

 = 208, patients were compared for post

I outcome. click here The cure was defined as a combined euthyroid and stable hypothyroid state following

I treatment. Logistic regression analysis was used for identifying prognostic factors. The propensity score was applied; 77 matched pairs (11 ratio) of high and normal turnover patients were selected as a validation set.

First

I cure rates of 28% in high turnover and 66% in normal turnover groups (

 = 0.001) were noted. The therapy cycles (median, 2 vs. 1) and cumulative

I activity (median, 15 vs. 7mCi) were required to cure hyperthyroidism in cohort 1 and cohort 2, respectively. Age (> 44years), higher grade of goitre, and 2-h RAIU (> 37%) were associated with

I therapy failure. The high turnover patients needed a factor of 1.5-2 times more

I activity to achieve a similar cure rate compared to the normal turnover patients. The first-dose cure rate was 31% vs. 60% by propensity score analysis (

 = 154), no way different (28% vs.66%) from the whole group of 312 patients.

High turnover Graves' disease patients, if administered standard

I activity, the outcomes shall be poor. To improve the success rate,

I activity should be increased by 1.5 to 2 times in the high turnover patients.

The online version contains supplementary material available at 10.1007/s13139-020-00674-3.

The online version contains supplementary material available at 10.1007/s13139-020-00674-3.Bacterial cancer therapy (BCT) approaches have been extensively investigated because bacteria can show unique features of strong tropism for cancer, proliferation inside tumors, and antitumor immunity, while bacteria are also possible agents for drug delivery. Despite the rapidly increasing number of preclinical studies using BCT to overcome the limitations of conventional cancer treatments, very few BCT studies have advanced to clinical trials. In patients undergoing BCT, the precise localization and quantification of bacterial density in different body locations is important; however, most clinical trials have used subjective clinical signs and invasive sampling to confirm bacterial colonization. There is therefore a need to improve the visualization of bacterial densities using noninvasive and repetitive in vivo imaging techniques that can facilitate the clinical translation of BCT. In vivo optical imaging techniques using bioluminescence and fluorescence, which are extensively employed to image the therapeutic process of BCT in small animal research, are hard to apply to the human body because of their low penetrative power. Thus, new imaging techniques need to be developed for clinical trials. In this review, we provide an overview of the various in vivo bacteria-specific imaging techniques available for visualizing tumor-treating bacteria in BCT studies.

Little is known about how sheltering in place to contain the spread of COVID-19 over extended periods affects individuals' psychological well-being. This study's objective was to analyze the factors associated with MSM's (men who have sex with men) low psychological well-being in the COVID-19 pandemic context.

This cross-sectional study was conducted online across Brazil (26 states and federal district) in April and May 2020. The participants were recruited using snowball sampling and Facebook posts. Data were collected using social media and MSM dating apps. We estimated the prevalence, crude prevalence ratio (PR), and the respective confidence intervals (CI95%).

The prevalence of low psychological well-being found in the sample was 7.9%. Associated factors were belonging to the youngest group (PR 2.76; CI95% 1.90-4.01), having polyamorous relationships (PR 2.78; CI95% 1.51-5.11), not complying with social isolation measures (PR 6.27; CI95% 4.42-8.87), not using the social media to find partners (PR 1.