Licampos9701

Tetralogy of Fallot is characterized by the presence of four congenital heart defects. Objective to describe the temporal trend and distribution of Tetralogy of Fallot, in children under one year in the Valencian Region.

Cases with Tetralogy of Fallot (code Q21.3 from the ICD10-British Paediatric Association) were selected from the Congenital Anomalies Population-based Registry between 2007-2017. Prevalence per 10,000 births with 95%CI was calculated, and a descriptive analysis of sociodemographic and clinical variables was made.

165 cases were identified (43.6% male, 30.9% female and 25.5% unknown). The overall prevalence was 3.1/10,000 births (95%CI2.6-3.6), being 2015 and 2017 the years with the highest (4.3/10,000 births and 4.7/10,000 births respectively) and 2011 with the lowest (1.8/10,000 births). 72.1% were live births, 24.8% Termination of Pregnancy for Fetal Anomaly (TOPFA) and 3.0% stillbirths. The prevalence in live births was 2.2/10,000 births (95%CI1.8-2.7) and in TOPFA it was 0.8/10,000 births (95%CI0.5-1.0), identifying an increasing trend along the period in the last one. 10.1% of live births died during the first year of life and 55.8% were diagnosed prenatally. Mothers younger than 20 years had the highest prevalence (4.8/10,000 births).

The prevalence obtained in the Valencian Region was slightly lower than EUROCAT's but coincides with that of the registries that are closer geographically, and in all of them it is noted that their increasing trend specifically affects cases ending in TOPFA.

The prevalence obtained in the Valencian Region was slightly lower than EUROCAT's but coincides with that of the registries that are closer geographically, and in all of them it is noted that their increasing trend specifically affects cases ending in TOPFA.The critical demand for eco-friendly, renewable, and safe energy resources is an essential issue encountered in the contemporary world. The catalytic transesterification of plant oils into biodiesel was assessed as promising a technique for providing new forms of clean and safe fuel. Natural clinoptilolite was doped with Na+ ions by green chemical reactions between sodium nitrite and green tea extract, producing a novel modified structure (Na+/Clino). The Na+/Clino product had an enhanced total basicity (6.41 mmol OH/g), ion exchange capacity (387 meq/100 g), and surface area (312.7 m2 g-1), which qualified it to be used as a potential basic catalyst for the transesterification of palm oil. Transesterification tests were statistically assessed using a response surface methodology and a central composite design. Considering the effect of how the significant factors interact with each other, the synthetic Na+/Clino achieved a 96.4% experimental biodiesel yield after 70 min at 100 °C in the presence of 2.75 wt% catalyst loading and a 12.51 methanol-to-palm-oil ratio. Based on the optimization function of the statistical model, the performance of Na+/Clino can theoretically be enhanced to increase the yield to 98.2% by expanding the test time to 85 min and the loading value to 3 wt%. The product yielded by the Na+/ClinO process is of adequate technical properties, considering the international levels for standard biodiesel (EN 14214 and ASTM D-6751). Finally, the prepared green Na+ doped clinoptilolite had excellent recyclability as a heterogeneous basic catalyst and displayed higher efficiency than several species of previously studied heterogeneous and homogenous catalysts.In this paper, Au nanoparticles (AuNPs) are prepared using wet chemical reduction transfer of dense AuNPs film by self-assembly to the surface of Ag grating, which is inverted from the inner DVD after evaporation. The Ag grating/AuNPs self-assembly hybrid substrate commonly used in surface-enhanced Raman scattering (SERS) research is produced. The coupling effect between AuNP-AuNP and AuNPs-Ag slugs can evidently enhance the local electric field. Experimental results show that the hybrid SERS substrate can detect 10-9 M Rh6G, and the enhancement factor reaches 4.4 × 105. This small, cheap hybrid substrate has enormous potential in the field of SERS sensing.The topological insulator PdBi2 exhibits two different crystal phases at ambient pressure, i.e., 'α-PdBi2' and ' -PdBi2'. The pressure dependence of crystal structure and superconductivity of α-PdBi2 has been fully elucidated thus far. However, the physical properties of β-PdBi2 crystals under pressure have not been sufficiently investigated. In this study, we fully investigate the crystal structure and superconductivity of β-PdBi2 under pressure based on synchrotron x-ray diffraction (XRD) patterns. The temperature dependence of β-PdBi2 indicates its superconductivity with a superconducting transition temperature (T c) as high as 4.10 K, and its crystal structure is tetragonal [space group of I4/mmm (no. 139)]. The XRD patterns at 0-22.0 GPa indicate no structural phase transitions, and the unit cell volume shrinks monotonically with pressure, unlike the behavior of α-PdBi2. Furthermore, α-PdBi2 transformed to β-PdBi2 under pressure. This suggests that β-PdBi2 is stable under pressure. The superconductivity is clearly observed at 0-11.8 GPa, and the value of T c is almost constant at ∼4.4 K. The temperature dependence of the upper critical field at ambient pressure and 10.7 GPa indicates that the superconductivity is not attributed to a simple s-wave dirty limit but an s-wave clean or p-wave polar model. This is the first systematic study of superconductivity of topological insulator β-PdBi2 under pressure.Recently, graphene has led to unprecedented progress in device performance at the atom limit. A high performance of field-effect transistors requires a low graphene-metal contact resistance. However, the chemical doping methods used to tailor or improve the properties of graphene are sensitive to ambient conditions. Here, we fabricate a single-layer perfluorinated polymeric sulfonic acid (PFSA), also known as Nafion, between the graphene and the substrate as a p-type dopant. The PFSA doping method, without inducing any additional structural defects, reduces the contact resistance of graphene by ∼28.8%, which has a significant impact on practical applications. This reduction can be maintained for at least 67 days due to the extreme stability of PFSA. Effective, uniform and stable, the PFSA doping method provides an efficient way to reduce the contact resistance of graphene applications.

Cataract surgery is one of the most common operations. Femtosecond laser-assisted cataract surgery (FLACS) is a technique that automates a number of operative steps.

To compare FLACS with phacoemulsification cataract surgery (PCS).

Multicentre, outcome-masked, randomised controlled non-inferiority trial.

Three collaborating NHS hospitals.

A total of 785 patients with age-related cataract in one or both eyes were randomised between May 2015 and September 2017.

FLACS (

= 392 participants) or PCS (

= 393 participants).

The primary outcome was uncorrected distance visual acuity in the study eye after 3 months, expressed as the logarithm of the minimum angle of resolution (logMAR) 0.00 logMAR (or 6/6 if expressed in Snellen) is normal (good visual acuity). Secondary outcomes included corrected distance visual acuity, refractive outcomes (within 0.5 dioptre and 1.0 dioptre of target), safety and patient-reported outcome measures at 3 and 12 months, and resource use. All trial follow-ups were perfoCharity (grant references GR000233 and GR000449 for the endothelial cell counter and femtosecond laser used).

This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 25, No. 6. See the NIHR Journals Library website for further project information. Moorfields Eye Charity (grant references GR000233 and GR000449 for the endothelial cell counter and femtosecond laser used).

Envisaging the poor solubility (56 ngml1) and permeability of tetrahydrocurcumin (THCC), it was formulated into lipidic nanostructures to enhance its bioavailability upon topical application to promote the healing process for skin inflammatory disorders. Lack of literature on a suitable method for determining THCC per se and nanoformulations prompted us to develop an RP-HPLC method to detect the drug in its nanostructures and in pig ear skin post dermatokinetics.

The present investigation aimed to develop a simple, precise and RP-HPLC method for the quantitative estimation of THCC in prepared lipidic nanostructures, its ointment, and in skin homogenate obtained post dermatokinetic study.

THCC encapsulated nanostructures and ointment were formulated using a modified emulsification method and embedded into an ointment base to enhance its spreadability and improve patient compliance. A fast and sensitive reverse-phase high-performance liquid chromatography method was developed using a Hypersil BDS reverse he method was found to be reproducible and robust, as shown by the low coefficient of variation and a constant analyte/IS ratio. It was successfully employed for the estimation of THCC assay in nanostructures and its ointment and dermatokinetic analysis in the skin.

Cancer is one of the diseases causing society's fears as a stigma of death and pain. Head and Neck Squamous Cell Carcinoma (HNSCC) is a group of malignant neoplasms of different locations in this region of the human body. It is one of the leading causes of morbidity and mortality in Brazil, because these malignant neoplasias, in most cases, are diagnosed in late phases. Surgical excision, chemotherapy and radiotherapy encompass the forefront of antineoplastic therapy; however, the numerous side effects associated with these therapeutic modalities are well known. Some treatments present enough potential to help or replace conventional treatments, such as Magnetic Hyperthermia and Photodynamic Therapy. Such approaches require the development of new materials at the nanoscale, able to carry out the loading of their active components while presenting characteristics of biocompatibility mandatory for biomedical applications.

This work aims to make a bibliographical review of HNSCC treatments. Recent techniquese conventional ones, but the association of these new therapies shows great potential, in other types of cancer, to improve the treatment efficacy.

The analysis shows that there is still much room for expanding research, especially for alternative therapies since most of the studies still focus on conventional treatments and on the quest to overcome their side effects. The scientific community needs to keep looking for more effective therapies generating fewer side effects for the patient. Currently, the so-called alternative therapies are being used in combination with the conventional ones, but the association of these new therapies shows great potential, in other types of cancer, to improve the treatment efficacy.

The link between bilirubin and cardiometabolic outcomes has been previously identified with positive health effects of mild hyperbilirubinaemia. On the other hand, recent evidence has suggested an association between low circulating bilirubin levels and obesity. This study was conducted to assess the association of total bilirubin levels with metabolic and cardiovascular risk factors related to obesity.

A total of 50 obese adults and 50 healthy controls matched for age and sex were enrolled in this study. Sovleplenib Syk inhibitor Anthropometric measurements, fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), HOMA- β (%), lipids profile, monocyte to lymphocyte ratio (MLR), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), uric acid, gamma glutamyl transpeptidase (GGT), AST/ALT ratio and total bilirubin were assessed.

Total bilirubin, high density lipoprotein cholesterol (HDL-C) and AST/ALT ratio were significantly lower, whereas fasting insulin, HOMA-IR, total cholesterol, triglycerides, low density lipoprotein cholesterol, NLR, uric acid and GGT were significantly higher in obese adults than in healthy controls.