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Ultimately, the integration of reinforcement learning algorithms with sophisticated behavioral and neuroscience techniques may be critical for advancing the understanding of the neurochemical basis of impulsive decision-making.Human Immunodeficiency Virus Type-I (HIV) is a health disparities issue that affects culturally and linguistically diverse (CALD) and underrepresented minority populations to a greater degree than non-Hispanic white populations. Neurologically speaking, CALD populations experience worse HIV-related health outcomes, which are exacerbated by inadequate neurocognitive measures, poor normative samples, and the complex interplay of sociocultural factors that may affect test interpretation. Although cross-cultural neuropsychologists are working diligently to correct this gap in the literature, currently, studies examining neurocognitive outcomes among CALD populations are sparse. The most well-studied CALD groups are of African American/Black and Latinx adults in the US, and the chapter therefore focuses on these studies. There is more limited work among other populations in the US, such as Asians, Native Hawaiians, Pacific Islanders, and American Indians/Alaskan Natives, and even fewer studies for many CALD populand interpretation of neurocognitive data and HAND diagnosis when working with HIV-positive CALD populations that would be relevant internationally are provided.PURPOSE Nowadays, no human neuroendocrine cell models derived from the neural crest are available. In this study, we present non-transformed long-term primary Neural Crest Cells (NCCs) isolated from the trunk region of the neural crest at VIII-XII gestational weeks of human foetuses obtained from voluntary legal abortion. METHODS AND RESULTS In NCC, quantitative real-time RT PCR demonstrated the expression of neural crest specifier genes, such as Snail1, Snail2/SLUG, Sox10, FoxD3, c-Myc, and p75NTR. Moreover, these cell populations expressed stemness markers (such as Nanog and nestin), as well as markers of motility and invasion (TAGLN, MMP9, CXCR4, and CXCR7), and of neuronal/glial differentiation (MAP2, GFAP, SYP, and TAU). Functional analysis demonstrated that these cells not only possessed high migration properties, but most importantly, they expressed markers of sympatho-adrenal lineage, such as ASCL1 and tyrosine hydroxylase (TH). Moreover, the expression of TH increased after the induction with two different protocols of differentiation towards neuronal and sympatho-adrenal phenotypes. Finally, exposure to conditioned culture media from NCC induced a mature phenotype in a neuronal cell model (namely SH-SY5Y), suggesting that NCC may also act like Schwann precursors. CONCLUSION This unique human cell model provides a solid tool for future studies addressing the bases of human neural crest-derived neuroendocrine tumours.INTRODUCTION Bartolomeo Vivarini (Venezia 1432c.-Venezia 1499c.) was an Italian painter during the Renaissance. The artist was widely influenced by Andrea Mantegna, whose opera was characterized by personages with anatomical details meticulously described. MATERIALS AND METHODS Some of the most valued paintings of Bartolomeo Vivarini were analyzed. Baricitinib Purpose of the present article is to describe these artworks focusing on female personages represented with thyroid swelling. RESULTS A recurring female model in Vivarini's artworks is portrayed with a goitrous neck. This might display a real prevalence of thyroid diseases among young women in the Renaissance age (e.g. postpartum thyroiditis). CONCLUSIONS Representation of goiter in the artworks of Vivarini and Mantegna reflects the increased anatomic accuracy and knowledge developed in art since Renaissance and Baroque.PURPOSE OF REVIEW An increasing body of evidence suggests that the gut microbiome influences the pathogenesis of insulin resistance and type 2 diabetes (T2D). In this review, we will discuss the latest findings regarding the mechanisms linking the gut microbiome and microbial metabolites with T2D and therapeutic approaches based on the gut microbiota for the prevention and treatment of T2D. RECENT FINDINGS Alterations in the gut microbial composition are associated with the risk of T2D. The gut microbiota can metabolize dietary- and host-derived factors to produce numerous microbial metabolites, which are involved in metabolic processes modulating nutrition and energy harvest, gut barrier function, systemic inflammation, and glucose metabolism. Microbial metabolites are important mediators of microbial-host crosstalk impacting host glucose metabolism. Furthermore, microbiome-based interventions may have beneficial effects on glycemic control. Future research is required to develop personalized T2D therapy based on microbial composition and/or metabolites.PURPOSE OF REVIEW Controversy surrounds the construct of food addiction. The current review examines neurobiological evidence for the existence of food addiction as a valid diagnosis. RECENT FINDINGS Recent neuroimaging studies suggest significant overlap in the areas of the brain that are activated in relation to both food and drug addiction. Specifically, areas of the brain implicated in executive functioning (e.g., attention, planning, decision-making, inhibition), pleasure and the experience of reward, and sensory input and motor functioning display increased activation among individuals with symptoms of both food and drug addiction. Proposed symptoms of food addiction mirror those comprising other substance use disorder diagnoses, with similar psychological and behavioral sequelae. Results of neuroimaging studies suggest significant overlap in the areas of the brain that are activated in relation to both food and drug addiction, providing support for continued research into the construct of food addiction.The original version of the chapter Enzyme-Ligand Interaction Monitored by Synchrotron Radiation Circular Dichroism was previously published non-open access. It has now been changed to open access under a CC BY 4.0 license and the copyright holder has been updated to 'The Author(s).' The book has also been updated with the change.