Kronborgudsen8361

The coagulation scar is narrow, thermal damage to the membranes is local (within 2700-3000 microns), the epithelialization of the suture was completed after 3 months and the maturation of the scar after 6 months. The method of HF-electric welding equally allows the formation of reliable biliodigestive and interintestinal anastomoses, both in conditions of unchanged and inflamed tissues. The everting weld connection prevents the occurrence of anastomotic strictures in the future.Objective - to evaluate changes in the structure and function of the liver and kidneys under non-lethal carbon tetrachloride intragastric administration. Experimental studies were performed on 46 white Wistar male rats. Within 7 days, the experimental group of animals underwent intoxication with the introduction of 0.5 ml of CCl₄. The state of liver function was evaluated by the activity of ALT and AST, the amount of bilirubin in the blood, the content of serum creatinine and urea, the amount of total serum protein. The state of renal function was assessed by changes in daily diuresis, glomerular filtration function, percentage of tubular reabsorption, serum creatinine and urea, indicators of chloride output and urine pH. The results of a study in experimental animals with the introduction of carbon tetrachloride showed that in the liver and kidneys there is a development of dystrophic lesions vacuoles in the hepatocytes and endothelial cells of the glomeruli, disorders of the structural and functional organiort function of red blood cells persists). The balance and intensity of lipid peroxidation processes and the antioxidant system are disturbed. Violation of the energy supply of the transmembrane potential, a decrease in ESR, and the content of total blood protein increases (the changes nomenclature of plasma proteins). With a non-fatal load of carbon tetrachloride, dystrophic changes in the liver and destructive changes in the kidneys were detected. The detoxification potential of the liver and urinary function of the kidneys decreased. Changes in nature were similar to those described in hepatorenal syndrome. However, taking into account that no nosology of liver damage was found, the activity of redox enzymes is preserved, the detected violations can be defined as pseudohepatorenal syndrome.The purpose of the study was to establish the dynamics of changes in morphometric parameters of the structural components of the rats' duodenal wall with long-term use of a complex of food additives sodium nitrite, sodium glutamate and Ponceau 4R. The work was performed on 84 adult nonlinear male rats, which were given to drink 10% sodium nitrite solution, sodium glutamate was administered at a dose of 20 mg/kg in 0.5 ml of distilled water, Ponceau 4R - at a dose of 5 mg/kg in 0.5 ml distilled water 1 time per day orally. Thus, the use of a complex of dietary additives of sodium nitrite, sodium glutamate and Ponceau 4R led to changes in the morphometric parameters of all structural components of the rats' duodenal wall. This reaction is aimed at neutralizing the alterative factor and restoring the morphofunctional state of the duodenum. By the end of the observation, complete recovery of structural components was not established due to the predominance of constant negative influence of the stimulus with the occurrence of dystophic-destructive changes.Objective - to study the ability of 2,6-dimethylpyridine-N-oxide to modify the cytogenetic effects in mouse bone marrow cells caused by the pro-oxidant mutagen Dioxidine. The cytogenetic activity and mutagen-modifying effect of the plant growth regulator 2,6-dimethylpyridine-N-oxide (Ivin) were studied by the method of accounting for chromosomal aberrations in the bone marrow cells of CD-1 mice (males) with a single joint exposure with Dioxidine. Ivin was administered single orally in the form of an aqueous solution at doses of 710, 71, and 0.7 mg/kg bw, which corresponds to 1/2, 1/20, 1/2000 of LD50 after intraperitoneally administered of Dioxidine at a dose 100 mg/kg. The animals of the positive control group were treated Dioxidine intraperitoneally at a dose of 100 mg/kg bw. Intact animals (negative control group) were orally administered purified, UV-sterilized, deionized water. It was shown that when combined with Dioxidine, Ivin at doses of 710, 71, and 0,7 mg/kg bw significally reduced the frequency of metaphases chromosome aberrations, relative to positive control by 55,56%, 66,70%, and 74,08% respectively. No multi-aberrant and polyploid cells were observed. In all variants of the experiment, only chromatid-type chromosome aberrations with single fragments were detected in the spectrum of chromosome aberrations. The severity of this effect had an inverse dose dependence with a decrease in the dose of Ivin, the cytogenetic effects of Dioxidine decreased to a greater extent than with high doses of Ivin. The high antimutagenic effect of Ivin was confirmed, which is expressed to a greater extent when it is combined with Dioxidine than with Cyclophosphamide. These findings may be associated with the genoprotective effect of Ivin, due to the stabilization of membranes and its antioxidant effect.High-resolution ultrasound (US) was used to examine 25 patients before the procedure and at the 2nd, 7th, 21st days and in 1.5 months after combined exposure to the skin of the face and neck with the ErYAG laser in cold ablation mode and with the neodymium (NdYAG) laser in long pulse mode. L-Arginine chemical structure The maximum dermis thickness was noted in the middle third (the standard measurement point along the mid-pupillary line in the projection of the infraorbital foramen) and composed 1,75±0,29 mm, the minimum on the neck and in infraorbital area - 1,2 (1,15; 1,3) mm and 1,15±0,15 mm, respectively. On the second day after the procedure, there was a significant increase up to 2,63±0,33 mm in the dermal thickness in the middle third in the projection of the infraobital foramen and up to 1,57±0,23 mm in the submental area of the neck due to all its layers in comparison with the values given before the procedure (p=0.005, p less then 0.0001). Visualization of the dermis layers was difficult in B-mode during ultrasound, the toughness of the tissues decreased at compression elastography, pronounced vascularization was detected in the CDI mode in comparison with the initial one before the procedure and persisted up to 6 weeks.