Kristensenhickman9118

In silico prediction of chemical ecotoxicity (HC50) represents an important complement to improve in vivo and in vitro toxicological assessment of manufactured chemicals. Recent application of machine learning models to predict chemical HC50 yields variable prediction performance that depends on effectively learning chemical representations from high-dimension data. To improve HC50 prediction performance, we developed an autoencoder model by learning latent space chemical embeddings. This novel approach achieved state-of-the-art prediction performance of HC50 with R2 of 0.668 ± 0.003 and mean absolute error (MAE) of 0.572 ± 0.001, and outperformed other dimension reduction methods including principal component analysis (PCA) (R2 = 0.601 ± 0.031 and MAE = 0.629 ± 0.005), kernel PCA (R2 = 0.631 ± 0.008 and MAE = 0.625 ± 0.006), and uniform manifold approximation and projection dimensionality reduction (R2 = 0.400 ± 0.008 and MAE = 0.801 ± 0.002). A simple linear layer with chemical embeddings learned from the autoencoder model performed better than random forest (R2 = 0.663 ± 0.007 and MAE = 0.591 ± 0.008), fully connected neural network (R2 = 0.614 ± 0.016 and MAE = 0.610 ± 0.008), least absolute shrinkage and selection operator (R2 = 0.617 ± 0.037 and MAE = 0.619 ± 0.007), and ridge regression (R2 = 0.638 ± 0.007 and MAE = 0.613 ± 0.005) using unlearned raw input features. Our results highlighted the usefulness of learning latent chemical representations, and our autoencoder model provides an alternative approach for robust HC50 prediction.Wastewater-based epidemiology (WBE) emerged as a powerful, actionable health management tool during the COVID-19 pandemic. Hypothesizing future uses, we explored its potential for real-time, tracking of progress in attaining United Nations Sustainable Development Goals (SDGs) globally as a non-expensive method using existing infrastructure. We inventoried (i) literature-documented sewerage infrastructure, (ii) demographics of populations served, and (iii) WBE markers informative of 9 SDGs. Among the 17 different sustainable development goals listed by the UN 2030 agenda, more than half of these may be monitored by using WBE monitoring at centralized treatment infrastructure as tabulated in this study. Driven mainly by COVID-19, WBE currently is practiced in at least 55 countries, reaching about 300 million people. Expansion of WBE to 109,000 + treatment plants inventoried in 129 countries would increase global coverage 9-fold to 34.7% or 2.7 billion, leaving out 5 billion people not served by centralized sewerage systems. Associations between population demographics and present-day infrastructure are explored, and geospatial regions particularly vulnerable to infectious disease outbreaks are identified. The results suggest that difference in the differential outcomes in well-being is an outcome of the sanitation infrastructure inequalities and lack of sanitation infrastructure creates doubly disadvantaged populations at risk of poor hygiene and cut off from the early-warning benefits of conventional WBE. This is the first study to explore the feasibility and potential barriers to the use of WBE for tracking the attainment of SDGs globally with at least 9 out of 17 SDGs.

The incidence of prostate cancer is increasing across the world, with over 1.2 million men diagnosed in 2018. Survival rates have increased significantly however the morbidity remains high. Men do report unmet sexual health needs post prostatectomy, despite this, many do not pursue treatment.

To explore men's perceptions of the education and support they receive surrounding post-prostatectomy erectile dysfunction and penile rehabilitation.

Systematic review and qualitative analysis based on Joanna Briggs Institute's methodology for conducting synthesis.

Based on the protocol registered with PROSPERO, data were collected from the following electronic databases MEDLINE, Web of Science, CINAHL, Psycinfo, The Cochrane Library and Embase. Epinephrine bitartrate clinical trial Titles and abstracts were screened against the inclusion and exclusion criteria, full texts were then screened, and the methodological quality of included studies was assessed using the Joanna Briggs Institutes Critical Appraisal Checklist for Qualitative Research by two ilitate education and treatment in a non-judgmental and all-inclusive approach.

Included in their extensive duties caring for hospitalized children, nurses are the frontline for pain assessment and treatment. Research has found that when nurses' assessments are compared with independent reports by the children or their parents, there are often differences. However, no studies have considered the contribution of analgesic medication consumption to this difference.

The aim of this study, was to assess the concordance between the pain scores recorded independently by nurses, children, and their parents both before and 1h after analgesic consumption.

The trial was registered at ClinicalTrials.gov (NCT04306679) and was conducted in a post-operative inpatient facility. Following surgery, at first request of analgesic, the clinical nurses recorded the child's pain, as part of routine clinical practice. Within 10min, the child recorded their pain level in a pain diary. At the same time, the parents separately reported their assessment of their child's pain. This process was repeated again ter analgesic consumption.

Disrupted sleep is a critical and highly prevalent concern among critically ill patients requiring intensive care. However, the question of which nonpharmacological intervention represents the best strategy for improving sleep quality remains unanswered.

To compare the efficacy of nonpharmacological interventions in improving sleep quality in people who are critically ill.

Databases, namely PubMed, Embase, CINAHL, and ProQuest Dissertations and Theses A&I, were searched from their inception up until January 15, 2021, for relevant randomised controlled trials. No language or time period restrictions were applied. Only randomised controlled trials examining the effects of nonpharmacological interventions on sleep among adults (aged ≥18 years) admitted to an intensive care unit were included. A random-effects model was used for data analyses. The study protocol was registered at PROSPERO (CRD42021232004).

Twenty randomised controlled trials involving 1,207 participants were included. Music combined w should incorporate the use of eye masks alone or music combined with eye masks into sleep care.

Cognitive impairment and dementia have emerged as one of the greatest global challenges for health and social care. Multidomain interventions that target several risk factors simultaneously may achieve optimal preventive effects for dementia.

This systematic review aimed to evaluate the effectiveness of multidomain lifestyle interventions for improving cognition and reducing the risk of dementia.

Systematic review and meta-analysis.

Five electronic databases, PubMed, Embase, Cochrane Library, CINAHL, and PsycINFO, were systematically searched from inception to April 17, 2021. Randomised controlled trials (RCTs) that assessed multidomain lifestyle interventions on the outcomes of cognition or dementia risk were included. The standardized mean difference (Hedges' g) was calculated using random-effects models. Risk of bias was assessed using the Revised Cochrane risk-of-bias assessment tool for randomised trials (RoB2), and the certainty of evidence was assessed using the five Grading of Recommendations gnitive domains.

The systematic review and meta-analysis have been registered in PROSPERO (CRD42021260122).

The systematic review and meta-analysis have been registered in PROSPERO (CRD42021260122).

The purpose of this study was to investigate the trajectory of mothers caring for children with blood cancer.

Fourteen mothers of children with blood cancer participated in in-depth interviews, from 30min to 2h in length, from July 1 through September 30, 2019. Grounded theory was used to investigate the trajectory for mothers of children with blood cancer. Purposive sampling and semi-structured questionnaires were employed to obtain in-depth interviews.

10 categories and 28 concepts were extracted from the raw data. The core category was 'living with anxiety from life to independence of their sick child' which consisted of three phases feeling chaos, immersing oneself in treatment, and returning to normal life. In the trajectory of mothers of caring for children with blood cancer, some participants felt like being on an island and hope to forget, whereas others tended to thank for the support of those near and find their own life according to the dimension of anxiety, support from others, and acceptance of illness.

Healthcare providers must have a better understanding of how the mothers of children with blood cancer can accept and cope with their child's illness in spite of the ongoing anxiety as well as need to explore the ways in which families can accept their child's chronic illness and reconstruct their life.

Healthcare providers must have a better understanding of how the mothers of children with blood cancer can accept and cope with their child's illness in spite of the ongoing anxiety as well as need to explore the ways in which families can accept their child's chronic illness and reconstruct their life.The thalamus is a densely connected collection of nuclei that play a critical role in gating information flow across the neocortex. Through diffuse reciprocal cortico-thalamo-cortical connectivity, the anterior and centromedian nuclei exert remarkable control over cortically expressed activity. Consequently, mounting evidence implicates these thalamic centres in both the genesis and propagation of aberrant epileptiform activity across the brain. The present work reviews existing literature with regards to the anatomy, function, and dysfunction of the anterior and centromedian thalamic nuclei as they relate to epileptogenesis and ictal dynamics in humans. A confluence of electrophysiological, anatomical, and neuromodulatory evidence links these thalamic hubs to a variety of epilepsy syndromes. These data are discussed as they relate to targeted thalamic neuromodulation.

Despite the widespread practice of nerve-sparing robot-assisted radical prostatectomy (nsRARP) for the treatment of localized prostate cancer (PCa), erectile dysfunction remains a significant sequela of radical prostatectomy.

This study aimed to compare the efficacy of tadalafil 5 mg once daily for erectile function recovery in patients who underwent nsRARP according to the timing of rehabilitation initiation.

In this double-blind, prospective pilot study, a total of 41 patients who underwent nsRARP were randomly assigned into 2 groups according to the timing of rehabilitation initiation. In the preRARP group (n=20), tadalafil was started 2 weeks before nsRARP, and in the postRARP group (n=21), it was started 4 weeks after nsRARP. Erectile function recovery after nsRARP was defined as an International Index of Erectile Function (IIEF-5) score of ≥17.

The measures of EF recovery were the changes in IIEF-5 score.

The rate of erectile function recovery at 12-month follow-up was 80.0% and 71.4% in the preRARP and postRARP groups, respectively.