Krarupadler3886

95) and r=0.77±0.15 (range 0.49 to 0.91), after excluding 8 patients with lower quality recordings. Cosine rhythmometry modeling showed mean acrophases occurring at 421±220 AM in left eyes and 339±150 AM in right eyes (r=0.48; P=0.034). Mean acrophase amplitude was 110.9±51.9 for left eyes and 107.8±46.2 for right eyes (r=0.79; P less then 0.001). No serious adverse events related to CLS monitoring were recorded. NMU chemical in vitro Transient conjunctival hyperemia (13 patients) and blurred vision (11 patients) were the most frequent adverse events. Conclusions In this group of untreated glaucoma patients, there was good intereye agreement for circadian IOP-related patterns using the CLS. These results show a higher degree of intereye symmetry, in terms of IOP peak timings and amplitudes, than previously reported with standard tonometry.Precis Improvements in post-trabeculectomy visual field outcomes were found to be significantly associated with pre-operative nerve fiber layer thickness parameters extracted from the sectorized structure-function relationship, baseline visual field and severity of glaucoma. Objective To determine whether the pre-operative structure-function relationship helps to predict visual outcomes at one-year post-trabeculectomy. Patients and methods 91 eyes from 87 participants who successfully underwent trabeculectomy were included in our study. All eyes received optical coherence tomography imaging and visual field assessment using 30-2 standard automated perimetry pre-operatively at baseline and post-operatively one year after trabeculectomy. Linear mixed model analysis was used to assess the association of structure and function at baseline, and multivariate analysis to investigate factors associated with post-operative visual field outcomes. Results Results from multivariate and univariate analysis for visual field one year after trabeculectomy showed that a positive pre-operative retinal nerve fiber layer thickness deviation from the structure-function model was found to be significantly associated with improved post-operative visual field outcomes (β=0.06▒dB/μm; 95% CI, 0.03 to 0.09). Other significant factors included baseline visual field mean deviation (β=-0.18; 95% CI -0.23 to -0.13) and the presence of severe glaucoma (β=-1.69; 95% CI, -2.80 to -0.57). Intraocular pressure was positively associated with improved visual field outcomes only in univariate analysis (β=0.06; 95% CI, 0.01 to 0.11). Conclusions and relevance Characteristics derived from the baseline structure-function relationship were found to be strongly associated with post-operative visual field outcomes. These findings suggest that the structure-function relationship could potentially have a role in predicting visual field progression after trabeculectomy.Background Individuals with chronic pain are at higher risk for suicide than other populations, and their potential for prescription drug use disorder (PDUD) enormously exists. This study aimed to estimate the prevalence and correlates of suicidality and to determine its relation to PDUD, among US adults with a history of chronic pain. Methods Data were obtained from the Collaborative Psychiatric Epidemiology Surveys (2001-2003). This analysis was limited to respondents who had a history of chronic pain (N = 5301). Logistic regression was used to determine the association between suicidality and prescription drug use disorder among those populations. Results Among study respondents, there was a strong positive association between PDUD and suicidal ideation and attempts (P value less then 0.001, = 0.006, respectively). Adjusted logistic regression analysis showed those with PDUD had 1.5 times greater likelihood of suicidal ideation (95% CI 1.2-1.8). Among respondents with a history of chronic pain and PDUD, Non-Hispanic Whites, female gender, lifetime mood and/or anxiety, and substance use disorders were associated with increased suicide risk (P value = 0.020, = 0.011, less then 0.001, less then 0.001, respectively). Conclusions There is a robust relationship between PDUD and suicidality in US adults with a history of chronic pain. Ethnicity, gender, and comorbid mood, anxiety or substance use disorders can predict suicidality among individuals with both chronic pain and PDUD. Longitudinal studies need to investigate the causal relationship between PDUD and suicidality among those populations.Purpose of review Hypertension is a major risk factor for cardiovascular disease, cerebrovascular events, and progression to end-stage kidney disease (ESKD). The kidneys play a causative role in hypertension, but they are also organs vulnerable to hypertensive injury. Thus far, goals for optimal blood pressure in chronic kidney disease (CKD) and ESKD patients are not fully elucidated. Herein, we critically review the existing evidence. Recent findings Large randomized controlled trials (RCTs) continue to be deemed as the best source of evidence to guide optimal blood pressure goals in CKD and ESKD patients. Despite recent advances, the growing body of literature does not permit drawing definitive conclusions. Few adequately powered RCTs have specifically assessed goals for treatment of hypertension in patients with CKD. The most recent large RCT in hypertension, the Systolic Blood Pressure Intervention Trial, included a subset of patients with CKD and provided some insights. For the ESKD population, trials to evaluate blood pressure goals are even more scarce. The Blood Pressure in Dialysis Trial was a relatively small pilot study that can be deemed as hypothesis generating. Summary Management of hypertension in CKD is essential for optimization of cardiovascular, cerebrovascular and renal outcomes. To date, the existing evidence does not fully clarify ideal targets for blood pressure control in this patient population.Purpose of review Acute mechanical circulatory support devices have become widely used in cardiogenic shock and high-risk percutaneous coronary intervention (PCI) but there remains significant controversy over the evidence supporting their use and the specific roles of various devices. In this review, we summarize major recent studies and identify key areas of future investigation. Recent findings In cardiogenic shock, uncontrolled single arm studies emphasizing early mechanical circulatory support (MCS) have showed promising results, but randomized trials have either been stopped prematurely or enrolled patients with advanced shock unlikely to benefit from MCS. In high-risk PCI, only one randomized controlled trail has been performed, with practice guided largely by observational data. Summary Randomized trials of current-generation mechanical support devices incorporating contemporary best-practices and performed in clearly defined populations are badly needed to clarify the role of acute MCS devices in cardiogenic shock and high-risk PCI.