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(P= 0.03), and lower SAPD increased 0.12 mm (P= 0.003). The 6- and 12-month postoperative visual analog scale back and leg scores significantly decreased compared with preoperatively (back mean change-5.98 and-6.05, P < 0.001; leg-6.86 and-6.89, P < 0.001).

Performing minimally invasive transforaminal lumbar interbody fusion at the symptomatic index level does not worsen canal dimension of asymptomatic adjacent segments during short-term follow-up. It might be possible to improve canal dimension at adjacent segments by changing disc height or lordosis at the fused level via adjusting size and position of the interbody cage.

Performing minimally invasive transforaminal lumbar interbody fusion at the symptomatic index level does not worsen canal dimension of asymptomatic adjacent segments during short-term follow-up. It might be possible to improve canal dimension at adjacent segments by changing disc height or lordosis at the fused level via adjusting size and position of the interbody cage.

To investigate if COVID-19 UK lockdown measures resulted in a delay in the presentation and treatment of patients with cauda equina syndrome (CES).

This is a multicenter retrospective study of patients with surgically treated CES across 3 time periods April-May 2020 (first lockdown), August-September 2020 (no-lockdown group), and January-February 2021 (second lockdown). Data regarding duration of symptoms, time from referral to admission, time from admission to surgery, and postoperative outcomes were collected.

A total of 56 patients (male 26, female 30, mean age 44.3 years) were included in the study (n= 14, n= 18, and n= 24 in the 3 time periods, respectively). There was no significant difference in duration of symptoms across the time periods (12.6 days vs. 8.2 days vs. 3.8 days) (P=0.16). Nearly all the patients were admitted within 48 hours of referral (n= 55, 98.2%). The majority of patients were operated on within 48 hours first lockdown (n= 12, 85.7%), no-lockdown (n= 16, 88.9%), and second lockdown (n= 21, 87.5%). The length of hospital stay was significantly shorter in the second lockdown (3.3 days) versus the other 2 time periods (4.4 days and 6.4 days) (P=0.02). Thirteen complications were present, with dural tear being the most common (n= 6, 10.7%). Majority reported symptom improvement (n= 53, 94.6%), with a similar number discharged home (n= 54, 96.4%).

Despite the pandemic, patients with CES were promptly admitted and operated on with good outcomes. Shorter duration of hospital stay could be attributed to adaptation of spinal services.

Despite the pandemic, patients with CES were promptly admitted and operated on with good outcomes. Shorter duration of hospital stay could be attributed to adaptation of spinal services.

Technological advances have significantly fostered the use of robotics in neurosurgery. Due to their novelty, there is a need to develop training methods within neurosurgical residency programs that provide trainees the skills to utilize these systems in their future practices safely and effectively.

We describe a detailed curriculum for trainees with significant responsibilities in the operating room, as well as hands-on and theoretical didactics. The curriculum for robot-assisted stereotactic electroencephalography (SEEG) and deep brain stimulation (DBS) electrode implantation technique and assessment tool has been designed based on Accreditation Council for Graduate Medical Education's (ACGME's) milestone requirement for surgical treatment of epilepsy and movement disorders. Residents were surveyed to assess their use of robotics in their surgical training.

Since 2019, more than 100 patients have undergone robot-assisted SEEG and DBS depth electrode implantations at our institution. Residents and fellows were involved in all aspects of surgical planning and execution and were encouraged to take an active role during procedures. Didactic sessions led by experienced faculty are emphasized as important learning tools prior to hands-on experience in the operating room. The results of the survey show that residents receive more training intraoperatively as compared to training sessions, yet trainees would benefit from more instruction on informative cadaveric simulation sessions.

Our curriculum was developed to become a structured tool for assessment of robotic education in neurosurgical training. This curriculum based on ACGME milestone requirements serve as a template for resident and fellow education in robotics in neurosurgery.

Our curriculum was developed to become a structured tool for assessment of robotic education in neurosurgical training. This curriculum based on ACGME milestone requirements serve as a template for resident and fellow education in robotics in neurosurgery.

The purpose of this study was to compare clinical and radiological results of lateral lumbar interbody fusion (LLIF) for lumbar degenerative disease in patients under the age of 80years with those over the age of 80years.

One hundred two patients who underwent LLIF without direct decompression were enrolled, including 92 patients who were less than 80years (group A) and 10 over 80years (group B). All patients were evaluated using numerical evaluation scale scores for low back pain, leg pain, and leg numbness, as well as demographic data, surgical data, and imaging data before and after LLIF surgery.

Patients over the age of 80 years were found to have longer hospital stays (P= 0.006) and more postoperative muscle weakness (P= 0.011) and endplate injuries (P= 0.038). C-176 cell line In addition, each numerical evaluation scale score improved significantly from preoperative to postoperative (P < 0.001). However, the changes in scores between preoperative and postoperative for each numerical evaluation scale were not significantly different between the 2 groups. Statistically significant increases in lumbar lordosis preoperatively compared with postoperatively were observed in patients under 80years but did not change in those over 80years.

These data suggest a need for awareness of intraoperative endplate injury and postoperative motor weakness. Critically, indirect decompression with LLIF in lumbar degenerative disease in patients over age 80 as well as those under age 80 has shown satisfactory clinical and radiological results. This study shows that age alone should not prevent older people from undergoing LLIF.

These data suggest a need for awareness of intraoperative endplate injury and postoperative motor weakness. Critically, indirect decompression with LLIF in lumbar degenerative disease in patients over age 80 as well as those under age 80 has shown satisfactory clinical and radiological results. This study shows that age alone should not prevent older people from undergoing LLIF.

Strokes are among the leading causes of death worldwide and have different characteristics. Different physiopathological mechanisms characterize the numerous subtypes of ischemic stroke (IS). In this study, we investigated the relationship between serum levels of autophagy-5 protein, apolipoprotein B-48, and oxidative stress markers in patients with ischemic stroke.

For this study, 100 participants were recruited, of which 50 were patients with IS and 50 were healthy individuals. We conducted a case-control study at Imam Reza Hospital from March 2019 to April 2020. Serum levels of ATG5, apo B-48, and oxidative stress markers were determined in both groups. Our Receiver Operating Characteristic Analysis evaluated the additional diagnostic value of these factors in both groups.

Diabetes, smoking, age, sex, alcohol consumption, weight, and height did not differ significantly between the 2 groups (P>0.05). However, the 2 groups had significant differences in hypertension and body mass index (P<0.05). Fifty-four percent (27 patients) of patients with IS had an ischemic stroke in large vessels, while 46% (23 patients) had an ischemic stroke in small vessels. Serum levels of ATG5, apo B-48, and oxidative stress markers were higher in the case group than in the control group (P<0.0001).

In patients with IS, serum levels of ATG5, apoB-48, malonaldehyde, total oxidative stress, and total antioxidant capacity can be used as novel biomarkers to predict or treat the disease.

In patients with IS, serum levels of ATG5, apoB-48, malonaldehyde, total oxidative stress, and total antioxidant capacity can be used as novel biomarkers to predict or treat the disease.

The aim of this study was to evaluate the course of occluded distal vessels before mechanical thrombectomy (MT) for acute large vessel occlusion (LVO) with non-contrast magnetic resonance imaging (MRI). The variable flip-angle three-dimensional turbo spin-echo (VRFA-3D-TSE) method was used to evaluate the course of occluded distal vessels quickly and clearly in acute LVO cases before MT.

Patients with acute LVO who were indicated for MT between April 2021 and March 2022 were examined by the VRFA-3D-TSE method to evaluate the distal course of occluded vessels. We included internal carotid artery (ICA) occlusion, M1 occlusion of the middle cerebral artery, and basilar artery (BA) occlusion. Preoperative images were compared to the angiographic findings after recanalization or with follow-up magnetic resonance angiography, and the results were assessed by 2 endovascular treatment specialists as excellent, good, or poor imaging.

MT was performed in a total of 27 patients. There were 17 patients with intracranial occlusion of the ICA, M1, and BA. Occlusion was found in the intracranial ICA in 6 patients, the M1 in 7, and the BA in 4. VRFA-3D-TSE MRI was performed in all patients, and the imaging was rated (by the 2assessors) as excellent in 12 of 17 and 14 of 17 cases, good in 5 of 17 and 3 of 17 cases, and poor in 0 of 17 cases.

In patients with acute LVO, VRFA-3D-TSE MRI enabled rapid and good depiction of the course of occluded distal vessels before MT without the use of contrast medium.

In patients with acute LVO, VRFA-3D-TSE MRI enabled rapid and good depiction of the course of occluded distal vessels before MT without the use of contrast medium.

The incidence of multiple primary malignancies (MPM) has increased in recent decades. Our aim was to evaluate incidence, clinical features, and survival in cases of spinal metastases from MPM in which one of the malignancies is lung cancer.

We retrospectively reviewed an institutional database of lung cancer patients with spinal metastasis and extracted all cases of MPM.

Among 275 patients who had spinal metastasis with lung cancer as one of the diagnoses, 21 (7.6%) patients with MPM were identified. Mean patient age was 68.5 years (95% confidence interval [CI], 65.3-71.7). The most common cancers diagnosed in addition to lung cancer were breast cancer (5 patients, 24%), upper aerodigestive tract cancer (4 patients, 19%), and prostate cancer (4 patients, 19%). Eighteen (86%) patients walked independently, and 3 (14%) patients walked with help. Seventeen (80.9%) patients had a good Karnofsky performance scale score. The median survivals from the date of first cancer diagnosis, last cancer diagnosis, and spinal metastasis diagnosis were 109.8 months (95% CI, 23.5-196.1), 17.8 months (95% CI, 5.8-29.8), and 10.3 months (95% CI, 5.4-15.2), respectively. Actual rates of survival at 6 months, 12 months, and 24 months from the date of spinal metastasis diagnosis were 81%, 42.9%, and 23.8%, respectively.

The present study is the first series to our knowledge to show that survival of patients with spinal metastasis and MPM involving lung cancer is not clearly inferior to that of patients with spinal metastasis and lung cancer alone.

The present study is the first series to our knowledge to show that survival of patients with spinal metastasis and MPM involving lung cancer is not clearly inferior to that of patients with spinal metastasis and lung cancer alone.