Knapphull1101

t the precision medicine strategies considering genetics and dietary habits to modify cardiovascular health for people at higher risk of genetically determined obesity.

Circulating insulin-like growth factor-I (IGF-I) is associated with the risk of several cancers. Dietary protein intake, particularly dairy protein, may increase circulating IGF-I; however, associations with different protein sources, other macronutrients, and fibre are inconclusive. To investigate the associations between intake of protein, macronutrients and their sources, fibre, and alcohol with serum IGF-I concentrations.

A total of 11,815 participants from UK Biobank who completed ≥4 24-h dietary assessments and had serum IGF-I concentrations measured at baseline were included. Multivariable linear regression was used to assess the cross-sectional associations of macronutrient and fibre intake with circulating IGF-I concentrations.

Circulating IGF-I concentrations were positively associated with intake of total protein (per 2.5% higher energy intake 0.56nmol/L (95% confidence interval 0.47, 0.66)), milk protein 1.20nmol/L (0.90, 1.51), and yogurt protein 1.33nmol/L (0.79, 1.86), but not with cheese protein-0.07nmol/L (-0.40, 0.25). IGF-I concentrations were also positively associated with intake of fibre (per 5g/day higher intake 0.46nmol/L (0.35, 0.57)) and starch from wholegrains (Q5 vs. Q1 1.08nmol/L (0.77, 1.39)), and inversely associated with alcohol consumption (>40g/day vs<1g/day-1.36nmol/L (-1.00,-1.71)).

These results show differing associations with IGF-I concentrations depending on the source of dairy protein, with positive associations with milk and yogurt protein intake but no association with cheese protein. The positive association of fibre and starch from wholegrains with IGF-I warrants further investigation.

These results show differing associations with IGF-I concentrations depending on the source of dairy protein, with positive associations with milk and yogurt protein intake but no association with cheese protein. The positive association of fibre and starch from wholegrains with IGF-I warrants further investigation.

We conducted a systematic review and meta-analysis to evaluate evidence from randomized controlled trials (RCTs) documenting the effectiveness of supplementation with pro-/synbiotics versus placebo controls on anthropometric and metabolic (glucoregulatory status, lipid profile) indices in adults with metabolic syndrome (MetS).

Databases of MEDLINE, Scopus, Embase, Web of Science, and Cochrane Library were searched through March 2020 to identify eligible RCTs evaluating the effects of pro-/synbiotic consumption in adults (≥18 years) with MetS. Mean differences (MDs) and 95% confidence intervals (CIs) were pooled using random-effects models.

Ten eligible publications (9 RCTs, n=344 participants) were included. Supplementation with pro-/synbiotics reduced total cholesterol (TC) in adults with MetS versus placebo (MD-6.66mg/dL, 95% CI-13.25 to-0.07, P=0.04, I

=28.8%, n=7), without affecting weight, body mass index, waist circumference, fasting blood sugar, homeostasis model assessment for insulin resistance, insulin, triglyceride, low-density lipoprotein cholesterol, or high-density lipoprotein cholesterol (P>0.05).

Pro-/synbiotic consumption may be beneficial in reducing TC levels in adults with MetS. However, our observations do not support the effectiveness of pro-/synbiotics consumption on other anthropometric or metabolic outcomes of MetS. Further investigations with larger sample sizes are required to confirm these findings.

Pro-/synbiotic consumption may be beneficial in reducing TC levels in adults with MetS. However, our observations do not support the effectiveness of pro-/synbiotics consumption on other anthropometric or metabolic outcomes of MetS. Further investigations with larger sample sizes are required to confirm these findings.

The aim of this study was to investigate the linear and nonlinear dose-response associations of animal-based dietary protein intake and risk of developing rheumatoid arthritis (RA).

A systematic search of MEDLINE, Scopus and Embase was conducted up to October 2020. Observational studies that report risk estimates of RA for animal-based protein consumption were included. We calculated pooled relative risks (RRs) by using a random-effects model. 4SC202 Linear and non-linear dose-response analyses were performed to examine the dose-response relations between animal-based protein consumption and RA.

Seven cohort studies (n=457,554) with 3545 incident cases and six case-control studies with 3994 cases and 5252 controls were identified. Highest compared with the lowest category of fish consumption was inversely associated with risk of RA (RR 0.89; 95% CI, 0.80 to 0.99; I

=0%, n=10). Also, a 100g/day increment in fish intake was associated with a 15% decreased risk of RA. Dose-response analysis showed a modest U-shaped association between fish consumption and incidence of RA, with the lowest risk at a fish intake of 20-30g/day (P

=0.04). We found no significant association between consumption of red meat, poultry or dairy and the risk of RA.

The present study revealed a significant reverse association between fish consumption and risk of RA. While we observed no association between red meat, dairy or poultry consumption and risk of RA. Further well-designed prospective studies are needed to support our findings.

The present study revealed a significant reverse association between fish consumption and risk of RA. While we observed no association between red meat, dairy or poultry consumption and risk of RA. Further well-designed prospective studies are needed to support our findings.Monochloramine (NH2Cl) is increasingly used as alternative disinfectant to free chlorine in industrial plants. After use in cooling systems, the waters are released to the environment and residual NH2Cl may be discharged into the receiving waters. As NH2Cl is suspected to exhibit toxicity towards aquatic organisms, a proper risk assessment of its occurrence in environmental waters is needed to prevent adverse effects on wildlife. For this purpose, a comprehensive model simulating monochloramine loss in natural riverine waters was developed. This model incorporates the following processes (i) autodecomposition; (ii) reaction with nitrite and bromide; (iii) oxidation with Dissolved Organic Carbon (DOC); (iv) oxidation with organic fraction of Suspended Particulate Matter (SPM); (v) reactions in bottom sediments and (vi) volatilization. The model was also designed to conduct uncertainty and sensitivity analysis. It was tested on several French rivers submitted to discharges of monochloraminated effluents and on several seasonal conditions.