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These services have been well received by users, but it is still necessary to systematize the provision of information services to identify which documents are of greatest interest and usefulness.80 years to Corresponding Member of the Russian Academy of Sciences, Professor, Honored Scientist of the Russian Federation Nikolay Nikolaevich Ivants - a leading Russian specialist in psychiatry and drug treatment, a scientist and clinician of world renown, an excellent teacher, competent organizer of research and treatment process, a careful and responsible manager.The authors present a clinical case of a female patient with depression who developed lichen planus during the COVID-19 pandemic and describe the anamnesis, skin and mental status of the patient. The phenomenon of amplified itching in the clinical picture in the post-covid period in the framework of depressive cataesthetic hyperesthesia is considered. A comprehensive psychosomatic assessment of the condition and the inclusion of approaches of psychocorrection in basic dermatotropic therapy contributed to the normalization of mood, rapid and complete reduction of itching, improvement of the skin status and patient's quality of life.The authors describe the clinical observation of a patient with a paraventricular tumor of the left frontal lobe and demonstrate the effectiveness of endoscopic biopsy of a volumetric mass of such localization through the lateral ventricle using intraoperative navigation. The disease manifested with convulsive seizures two years before the patient was admitted to the hospital. During this period of time, he was repeatedly examined. The dimensions of the volumetric formation remained unchanged. Based on the data obtained, it was not possible to accurately verify the type of tumor. Anticonvulsant therapy was ineffective. The patient underwent surgery - endoscopic partial removal of the tumor (biopsy) and opening of the tumor cyst through the left lateral ventricle using intraoperative navigation. Clinical improvement in the patient's condition was achieved. After the operation, the headaches and the seizures stopped.The article describes the history of the Department of Nervous Diseases, Medical Genetics and Neurosurgery of the Daghestan State Medical University on the basis of literature data and archival sources introduced into scientific circulation for the first time. The department, created in 1936, has gone through a difficult path in its formation and development. The authors reconstruct the history of the formation of this department of the university, dwelling on the problems faced by its first employees. Special attention is paid to the work of the department during the Great Patriotic War, when its staff was reduced to a minimum. The authors describe the appearance, stages of development and successful functioning of the scientific school for the study of thermoregulation under the guidance of Associate Professor V.A. Liechtenstein. The formation of the teaching of neurosurgery, as well as the work of the department in recent years, is described.

To search for correlations between intraoperative electrocorticographic data and seizure control after the multiple hippocampal transections (MHT) in patients with symptomatic pharmacoresistant medial temporal lobe epilepsy.

Six patients underwent MHT nearby the hippocampus. The left dominant hemisphere was affected in all cases. Patients had normal memory function. Follow up was 18 to 24 months. Scalp electroencephalogram (EEG) and electrocorticography (ECoG) were intaoperatively recorded. Transections of the hippocampus were performed until ECoG epileptiform discharges stopped.

Seizure control was achieved in five patients. Synchronous epileptiform activity disappeared in the hippocampus in all patients after MHT. Complete disappearance of epileptiform activity in the hippocampus and basal cortex was demonstrated in 2 cases. The epileptiform activity remained in the basal cortex in 3 patients.

Using the method of hippocampal transections it was possible to achieve the disappearance of synchronous ep 4 of 5 cases after the resection of the pathological substrate, uncus and amygdala.

To personalize pharmacotherapy with aripiprazole in patients with schizophrenia via therapeutic drug monitoring (TDM).

TDM of aripiprazole (ARI) and its active metabolite dehydroaripiprazole (DHA) was performed for patients diagnosed with schizophrenia (ICD-10 F20.00; F20.01; F20.02). Thirty-six parameters were assessed. To carry out TDM, the method of high-performance liquid chromatography with mass spectrometry was chosen employing a validated method.

TLM was performed in a group of young patients 26.5±10.1 years old, average weight 77.2±16.2 kg, average PANSS score 81.4±21.4, UKU score 14.5±3.9. An average ARI concentration was 18.4±7.9 mg, serum ARI concentration 417.9±362.4 ng/ml, serum DHA concentration 117.5±116.1 ng/ml and the total concentration 535.4±478.5 ng/ml. Equations of correlation dependences of concentration on dose are obtained for ARI and DHA.

The results show the significant metabolism of ARI. A combined determination of the main substance and its active metabolite DHA in the patient's blood serum is advisable for correct assessment of the TLM result in patients with mental diseases.

The results show the significant metabolism of ARI. A combined determination of the main substance and its active metabolite DHA in the patient's blood serum is advisable for correct assessment of the TLM result in patients with mental diseases.

To conduct a comparative analysis of psychopharmacotherapy effectiveness in hypochondriac disorders of late age and to identify the optimal combinations of drugs depending on the thymopathic (hypothymic and/or anxiety) components accompanying the main hypochondriac manifestation.

One hundred and eight female inpatients, aged from 50 to 88 years, with leading hypochondriac symptoms of non-delusional level were enrolled in the study. All patients were examined clinically and psychopathologically using psychometric scales the Montgomery-Asberg Depression Rating Scale, the Hamilton Anxiety Rating Scale, the hypochondria rating scale and the UKU side-effect rating scale.

Based on the psychometric assessment, the patients were divided into the following groups group 1 - subjects with hypochondriac symptoms without accented thymopathic component (

=18); group 2 - subjects with a high level of hypothymia (

=49); group 3 - subjects with a high level of anxiety (

=22); group 4 - subjects with a high level of bondriac disorders of late age in most cases are accompanied by depressive and/or anxiety symptoms, which must be taken into account for improvement of diagnostic effectiveness and relevant selection of therapy.

Hypochondriac disorders of late age in most cases are accompanied by depressive and/or anxiety symptoms, which must be taken into account for improvement of diagnostic effectiveness and relevant selection of therapy.

To study the prevalence of clinical manifestations of postcoid syndrome in patients at an outpatient neurological appointment, to evaluate the effectiveness of therapy regimens using Cortexin at doses of 10 mg and 20 mg IM for 10 days.

674 neurologists from all regions of the Russian Federation, Azerbaijan, Kyrgyzstan and Kazakhstan took part in the study. A total of 979 COVID-19 patients were recruited. The average age is 54.6±0.45 years. The duration of the transferred SARS-CoV-2 days and from 1 month or more 12. 3 visits were carried out 1 on the day of treatment (assessment of complaints, analysis of scale indicators, prescription of the drug Cortexin in doses of 10-20 mg/m for 10 days). 2 (telephone survey) visit for 10-14 days, 3 visit - for 30 days at the reception. The condition was assessed using the Asthenia Assessment Scale (MFI-20), the Brief Mental Status Assessment Scale (MMSE questionnaire), the Schulte test, and the Subjective Treatment Quality Assessment Scale.

The daily proportion of pere was no significant correlation of clinical symptoms with the severity of COVID-19, the percentage of lung tissue damage, and different periods of postcovid syndrome. The clinical efficacy of the drug Cortexin in dosages of 10 and 20 mg for the correction of cognitive and asthenic disorders has been proven. Revealed anti-anxiety, antidepressant and anxiolytic activity of Cortexin is more pronounced when using a dosage of 20 mg.

The study was to investigate the role of moderate and severe anxiety in development of psychovegetative syndrome after coronary artery bypass graft (CABG), to describe the nature and direction of resulting autonomic dysfunction and to study possibilities of anti-ancient therapy.

We studied 33 patients (19 - in the main group, 14 - in the comparison group) on average 13 days after CABG and in dynamics in the process of early postoperative rehabilitation. A point assessment of the psychological and autonomic spheres, and sleep quality was made. Indicators of vegetative tone and vegetative regulation were studied, in particular, temporal and spectral indicators of heart rate variability. In addition to basic therapy for ischemic heart disease (IHD), the patients in main group were received therapy with alimemazine.

In most cases, after CABG, moderate situational and personal anxiety and sleep disturbances were recorded in combination with autonomic dysregulation with a predominance of sympathetic influencecan probably become a factor contributing to the successful rehabilitation of patients after CABG in the early and late postoperative periods, and the prevention of progression of IHD.

To compare the structure of cognitive deficit in patients with glaucoma, Alzheimer's disease (AD) and vascular dementia (VD).

Ninety patients were comprehensively examined and divided into 3 groups of 30 people each AD group, VD group and open-angle glaucoma group. All patients underwent neurological and neuropsychological examination.

The data on the similarity of the structure of cognitive deficit in patients with AD and glaucoma were obtained. More than half of patients with open-angle glaucoma were newly diagnosed with moderate cognitive impairment.

The results indicate the need for a comprehensive neurological and neuropsychological examination of patients with glaucoma for the early diagnosis of cognitive disorders, timely therapy and an improvement in the prognosis of the disease.

The results indicate the need for a comprehensive neurological and neuropsychological examination of patients with glaucoma for the early diagnosis of cognitive disorders, timely therapy and an improvement in the prognosis of the disease.

To evaluate the efficacy and safety of samPEG-IFN-β1a 180 μg and 240 μg administered once every 2 weeks for the treatment of relapsing remitting multiple sclerosis (RRMS) compared to placebo and low dose interferon beta-1a (LIB) 30 μg administered once weekly. The primary endpoint after 52 weeks of therapy was the time to first relapse, the hypotheses of non-inferiority and superiority to LIB were tested.

This international, multicenter, double blind, comparative, placebo-controlled clinical study enrolled 399 patients with the diagnosis of RRMS, randomized in 4 groups samPEG-IFN-β1a180 μg (

=114), samPEG-IFN-β1a 240 μg (

=114), LIB (

=114) and placebo (

=57). Placebo group patients participated in the study for 20 weeks. SP 600125 negative control research buy After 52 weeks of therapy and 4 weeks of follow-up, LIB group patients completed their participation in the study, patients from PEG-IFN-β1a groups continued to receive therapy until week 100 inclusive. The article presents the results of an analysis conducted after the end of 52 weeks of a double-blind, comparative, randomized, placebo-controlled clinical trial.