Kaplanbering0858

To systematically review the efficacy and safety of Ligustrazine in the treatment of idiopathic pulmonary fibrosis (IPF).

The electronic literature databases (PubMed, EMbase, CNKI, WanFang database, and VIP) were retrieved through a computer to find out the randomized controlled trials (RCT) of Ligustrazine in the treatment of IPF according to the inclusion/exclusion criteria screening test. Cochrane's bias risk table was also used to evaluate the quality of the study and to extract effective data. RevMan 5.3 was used for statistical analysis.

A total of 7 RCTs (a total of 366 patients, including 196 in experimental and 170 in control group). Compared with the control group, Ligustrazine could improve the clinical symptoms ([OR] = 2.20, 95% CI [1.40, 3.46],

=0.0006), lung function (VC % [MD] = 3.92, 95% CI [0.68, 7.17],

=0.02), (TLC% [MD] = 4.94, 95% CI [0.37, 9.52],

=0.03), the pulmonary diffusion function (DLCO % [MD] = 9.12, 95% CI [5.70, 12.55],

< 0.00001), and arterial blood gas analysineed to be further analyzed and determined. It can be considered as a new alternative and complementary medicine to be promoted and recommended for use in medical units in various countries in the world and it solved the difficult problem of conventional drug treatment of IPF; therefore, more research strength can be put in the treatment of the pathological mechanism of IPF for further exploration. The study was registered under registration number CRD42020193626.

To evaluate the evidence for the efficacy and safety of acupuncture at Tianshu (ST25) for functional constipation (FC).

We systematically searched seven databases to identify randomized controlled trials of acupuncture at ST25 alone or in combination with conventional therapy in the treatment of FC. Risk ratios (RRs) and mean differences (MDs) were calculated using RevMan 5.3 with 95% confidence interval (CI).

The study included ten trials with 1568 participants. Meta-analysis showed that the Cleveland Constipation Score (CCS) for deep needling was significantly lower than that for lactulose (deep needling with low-frequency dilatational wave MD -0.58, 95% CI -0.94 to -0.22; deep needling with sparse wave MD -3.67, 95% CI -6.40 to -0.94; deep needling with high-frequency dilatational wave MD -3.42, 95% CI -5.03 to -1.81). Furthermore, CCS for shallow needling with high-frequency dilatational wave was lower than that for lactulose (MD -1.77, 95% CI -3.40 to -0.14). In addition, when deep needling was comhan conventional treatment, with the rate of AE being significantly lower for both deep needling and shallow needling. The trial is registered with https//www.crd.york.ac.uk/prospero/(CRD42019141017)).Vehicular emissions have been playing a pivotal role in deteriorating air quality in many urban parts of Nepal causing adverse impacts upon the health of commuters and pedestrians attributed to severe respiratory diseases. Primary data such as the number of vehicles (N) were obtained using two-hour peak (8 am to 10 am) and two-hour nonpeak (1 pm to 3 pm) count, after which average annual vehicle kilometer (VKT) and fuel economy (F) required for emission load estimation were obtained from vehicle survey using the simple random sampling method, sampling size taken statistically under 5% margin of error. AUPM-170 manufacturer Secondary data in this study include emission factors and derived equations from a published article. The vehicular emission load of Bhaktapur Municipality were found to be 3,310 tons/year including CO2, CO, NOx, HC, and PM10 of which CO2 accounts for 94.36% of total emissions followed by CO (4.39%), HC (0.72%), NOx (0.35%), and PM10 (0.18%), respectively. Significant positive correlation was found (r = 0.92, p=0.002) between CO2 and PM10 (r = 0.87, p=0.009), between CO2 and NOx (r = 0.90, p=0.004), between CO and HC (r = 0.74, p=0.05), and between NOx and PM10, respectively. The scenario analysis shows that the introduction of electric vehicles at different rates within the municipality can reduce the emissions to a significant amount. Exponential growth in vehicular gaseous pollutants potent to jeopardize the environment and welfare can become inevitable in the future if clean energy technology is not promoted early.

Waterpipe nicotine dependence and its association with depressive symptoms and dual usage among adolescents are currently not examined in the literature. Adolescents are a vulnerable population that is susceptible to depression and initiation of tobacco use. We aim, in this novel study, to assess the association between depressive symptoms and waterpipe nicotine dependence among adolescents in Jordan, evaluate the association between waterpipe smoking status (waterpipe smoker vs. dual user) and waterpipe nicotine dependence, and assess the internal validity of the Waterpipe Nicotine Dependence Scale (WNDS).

A cross-sectional study among adolescents of grade 9

to 12

in Jordan was conducted through multistage cluster random sampling. The self-reported Arabic Youth Tobacco Use Composite Measure Questionnaire (YTUCM) was used to collect the surveys that include demographic information, smoking status, and the WNDS to assess waterpipe nicotine dependence and depressive symptoms. Multiple linear regression of the WNDS and the short- and long-term consequences of dual usage.

Tendon injuries are common musculoskeletal disorders in clinic. Due to the limited regeneration ability of tendons, tissue engineering technology is often used as an effective approach to treat tendon injuries. Silk fibroin (SF) films have excellent biological activities and physical properties, which is suitable for tendon regeneration. The present study is aimed at preparing a SF film with a bionic microstructure and investigating its biological effects.

A SF film with a smooth surface or bionic microstructure was prepared. After seeding tendon stem/progenitor cells (TSPCs) on the surface, the cell morphology, the expression level of tenogenic genes and proteins, and the focal adhesion kinase (FAK) activation were measured to evaluate the biological effect of SF films.

The TSPCs on SF films with a bionic microstructure exhibited a slender cell morphology, promoted the expression of tenogenic genes and proteins, such as SCX, TNC, TNMD, and COLIA1, and activated FAK. FAK inhibitors blocked the enhanced expression of tenogenic genes and proteins.