Johnscowan1638

HgSe colloidal quantum dot films are made by using a hybrid ligand exchange (HgSe/hybrid) in polar inks and compared with the solid-state ligand exchange using ethanedithiol (HgSe/EDT). In both systems, the conductance shows a peak at one-electron filling of the 1Se state and a dip at 2 electrons before filling the 1Pe state. The HgSe/hybrid films show a ∼100-fold increased mobility, reaching up to ∼1 cm2/Vs for 7.5 nm diameter particles. While field effect transistor and Hall measurements give similar carrier density and mobility, the temperature dependence of the mobility is consistent with hopping transport.Cannabinoid sensing in biofluids provides great insight into the effects of medicinal cannabis on the body. The prevalence of cannabis for pain management and illicit drug use necessitates knowledge translation in cannabinoids. In this Review, we provide an overview of the current detection methods of cannabinoids in bodily fluids emphasizing electrochemical sensing. First, we introduce cannabinoids and discuss the structure and metabolism of Δ9-THC and its metabolites in relation to blood, urine, saliva, sweat, and breath. Next, we briefly discuss lab based techniques for cannabinoids in biofluids. While these techniques are highly sensitive and specific, roadside safety requires a quick, portable, and cost-effective sensing method. These needs motivated a comprehensive review of advantages, disadvantages, and future directions for electrochemical sensing of cannabinoids. The literature shows the lowest limit of detection to be 3.3 pg of Δ9-THC/mL using electrochemical immunosensors, while electrodes fabricated with low cost methods such as screen-printing and carbon paste can detect as little as 25 and 1.26 ng of Δ9-THC/mL, respectively. Future research will include nanomaterial modified working electrodes, for simultaneous sensing of multiple cannabinoids. Additionally, there should be an emphasis on selectivity for cannabinoids in the presence of interfering compounds. Sensors should be fully integrated on biocompatible substrates with control electronics and intelligent components for wearable diagnostics. We hope this Review will prove to be the seminal work in the electrochemical sensing of cannabinoids.Development of highly efficient nonprecious metal (NPM) catalysts for oxygen reduction reaction (ORR) in acidic media is challenging but of great significance. Herein, an effective ORR catalyst based on Fe nanoparticles encapsulated by S,N-codoped few-layer defective carbon (Fe@S,N-DC) was synthesized via a microwave-assisted strategy. The obtained Fe@S,N-DC nanocomposite showed a remarkable electrocatalytic activity toward ORR in acidic media, with a half-wave potential (E1/2) of +0.785 V versus reversible hydrogen electrode, which was 80 mV more positive than that of the sulfur-free counterpart (Fe@N-DC). Lurbinectedin in vivo Furthermore, due to the protection by the S,N-codoped carbon shell, the Fe@S,N-DC nanocomposite displayed apparent stability with only a 13 mV negative shift of E1/2 after 10,000 cycles and excellent tolerance to methanol. X-ray absorption near-edge spectroscopy measurements confirmed the formation of multiple defective sites on the S,N-codoped carbon surface and strong interfacial electron transfer from the Fe core to the outer carbon surface, as compared to the sulfur-free counterpart. The enriched electron density on the defective carbon surface of Fe@S,N-DC, induced by the interfacial electron transfer, facilitated the reduction of O2 to OOH*, leading to enhanced ORR performance. These results shed light on the significance of S doping in Fe-N-C catalysts in the design of high-performance NPM catalysts for ORR in acidic media.BACKGROUND There is growing evidence that the response to chemotherapy may be affected by Androgen Receptor (AR) expression suggesting that triple-negative breast cancers (TNBC) AR+ and quadruple negative breast cancer (QNBC) subtypes may have different diseases behavior. METHODOLOGY We retrospectively estimated the predictive value of the AR expression in stage II and stage III TNBC patients treated with neoadjuvant chemotherapy (NAC) and correlated with the rate of pathological response (pCR). RESULTS Of 89 TNBC patients, 29 patients (32.6%) were TNBC AR+ and 60 patients (67.4) were QNBC. Most of the patients were less than 60 years old. Of note, approximately 62% in the QNBC group were less than 40 years old compared with 39 % in the TNBC AR+ group. The Ki-67 expression was higher in the QNBC in comparison with TNBC AR+ being 86.7% and 65.5%, respectively. QNBC subgroup showed higher rates of pCR compared with TNBC; 60% and 24%, respectively. Higher Ki-67 expression, higher grade, and lymph node involvement were statistically significantly correlated with the rate of pCR in the QNBC group (p=0.02, p=0.04, and p=0.03, respectively). In contrast, no significant association was observed between pCR and clinical-pathological features in the TNBC AR+ group. CONCLUSION Our results suggested that the AR expression in TNBC may be applied as a predictive marker for NAC. TNBC AR+ had a lower rate of pCR compared with QNBC, suggesting that this subtype may have a partial chemoresistance.BACKGROUND Egypt has the highest prevalence of hepatitis C virus (HCV) worldwide. Which make liver cirrhosis and hepatocellular carcinoma (HCC) major health concerns in Egypt. Circulating microRNAs (miRNAs) have been investigated as biomarkers for malignancies. We investigated miRNA gene expression of Lethal-7 (let-7) cluster let7-a-1, let-7d-1, let-7f-1 and miRNA (miR)143/145 cluster in sera of HCC patients and chronic HCV patients. METHODS The study included 40 post HCV-Hepatocellular carcinoma patients, 40 chronic HCV patients divided into 2 subgroups, 20 cirrhotic patients and 20 non-cirrhotic patients, and 40 apparently healthy subjects as a control group. Gene expression analysis for studied miRNAs was done using quantitative SYBR Green reverse-transcription Real-Time polymerase chain reaction (PCR). RESULTS We found that Let-7a-1 gene expression was significantly downregulated in the serum of HCV-HCC patients than in HCV non HCC cirrhotic group and was significantly upregulated in the serum of liver cirrhosis patients than HCV non-cirrhotic group.