Jeppesengreve8048

Our study reveals that sex chromosome heteromorphy evolved independently at the geographic lineage level in this species complex.

Continuous renal replacement therapy (CRRT) is the standard treatment for severe acute kidney injury in critically ill patients. However, a practical consensus for discontinuing CRRT is lacking. We aimed to develop a prediction model with simple clinical parameters for successful discontinuation of CRRT.

Adult patients who received CRRT at Samsung Medical Center from 2007 to 2017 were included. Patients with preexisting ESRD and patients who progressed to ESRD within 1 year or died within 7 days after CRRT were excluded. Successful discontinuation of CRRT was defined as no requirement for renal replacement therapy for 7 days after discontinuing CRRT. Patients were assigned to either a success group or failure group according to whether discontinuation of CRRT was successful or not.

A total of 1,158 patients were included in the final analyses. The success group showed greater urine output on the day before CRRT discontinuation (D-1) and the discontinuation day (D0). Multivariable analysis identified that urine output ≥300 mL on D-1, and mean arterial pressure 50∼78 mm Hg, serum potassium <4.1 mmol/L, and BUN <35 mg/dL (12.5 mmol/L) on D0 were predictive factors for successful discontinuation of CRRT. A scoring system using the 4 variables above (area under the receiver operating curve 0.731) was developed.

Scoring system composed of urine output ≥300 mL/day on D-1, and adequate blood pressure, serum potassium <4.1 mmol/L, and BUN <35 mg/dL (12.5 mmol/L) on D0 was developed to predict successful discontinuation of CRRT.

Scoring system composed of urine output ≥300 mL/day on D-1, and adequate blood pressure, serum potassium less then 4.1 mmol/L, and BUN less then 35 mg/dL (12.5 mmol/L) on D0 was developed to predict successful discontinuation of CRRT.

Saliva is increasingly used as a diagnostic tool as it is non-invasive, easily accessible, and less stressful compared to blood sampling. Saliva has a vital role in maintaining oral health. It is necessary for the salivary pH to be neutral in the oral cavity for the optimal functioning of its components. Stress has an effect on salivary pH.

To study the effect of a mind-body intervention like Sudarshan Kriya yoga (SKY) on the salivary pH.

An exploratory pilot study involving an open trial on 321 healthy individuals who were novice to SKY was conducted. The salivary pH was measured before and after a single 90-min session of SKY.

The salivary pH continued to be neutral after the intervention in the group that had initial neutral pH. There was a statistically significant shift of pH towards neutral in both the groups that had either acidic or alkaline pH initially.

Mind-body interventions like SKY modulate the salivary pH to bring it to the range of optimal functioning. This pilot study provides information for future long-term studies that can be implemented with measures of anxiety and stress along with measuring other salivary biomarkers.

Mind-body interventions like SKY modulate the salivary pH to bring it to the range of optimal functioning. This pilot study provides information for future long-term studies that can be implemented with measures of anxiety and stress along with measuring other salivary biomarkers.

Recent studies have identified the combination of vancomycin with piperacillin-tazobactam (VPT) to be associated with increased nephrotoxicity. Multiple, large cohort studies have found this widely used combination to have a higher risk of nephrotoxicity than other regimens in a variety of populations.

This review summarizes the epidemiology and clinical features of VPT-associated acute kidney injury (AKI). Potential mechanisms involved in the pathogenesis of this phenomenon are also discussed. Key Message VPT-associated nephrotoxicity is a recently recognized clinical entity. Clinical strategies to minimize the risk of toxicity in this setting include antimicrobial stewardship, monitoring of kidney function, and emerging data supporting the potential role for novel biomarkers in predicting and managing AKI.

This review summarizes the epidemiology and clinical features of VPT-associated acute kidney injury (AKI). Potential mechanisms involved in the pathogenesis of this phenomenon are also discussed. Key Message VPT-associated nephrotoxicity is a recently recognized clinical entity. Clinical strategies to minimize the risk of toxicity in this setting include antimicrobial stewardship, monitoring of kidney function, and emerging data supporting the potential role for novel biomarkers in predicting and managing AKI.

There have been some reports on the coexistence of psoriasis and atopic dermatitis; however, the longitudinal relationship between these two diseases remains unclear.

This study aimed to investigate the bidirectional association between psoriasis and atopic dermatitis.

This cohort study recruited patients from the National Health Insurance Research Database in Taiwan. We included 8,206 patients with psoriasis and 32,824 matched controls to assess the risk of atopic dermatitis and 25,743 patients with atopic dermatitis and 102,972 matched controls to assess the risk of psoriasis. Cox regression model was used for the analyses.

After adjusting for potential confounders, patients with psoriasis had a higher risk of atopic dermatitis (adjusted hazard ratio [aHR] 13.01; 95% CI 10.23-16.56) than the controls. Patients with atopic dermatitis had a higher risk of psoriasis (aHR 10.37; 95% CI 6.85-15.69) than the controls. Stratified analyses revealed similar results in both sexes and all age groups.

Our study demonstrated a bidirectional association between psoriasis and atopic dermatitis, suggesting that psoriasis and atopic dermatitis are not mutually exclusive and may share some biological mechanisms.

Our study demonstrated a bidirectional association between psoriasis and atopic dermatitis, suggesting that psoriasis and atopic dermatitis are not mutually exclusive and may share some biological mechanisms.Bone metastases occur in 65%-80% advanced breast cancer patients. Although significant progresses have been made in understanding the biological mechanisms driving the bone metastatic cascade, traditional 2Din vitromodels and animal studies are not effectively reproducing breast cancer cells (CCs) interactions with the bone microenvironment and suffer from species-specific differences, respectively. Moreover, simplifiedin vitromodels cannot realistically estimate drug anti-tumoral properties and side effects, hence leading to pre-clinical testing frequent failures. To solve this issue, a 3D metastatic bone minitissue (MBm) is designed with embedded human osteoblasts, osteoclasts, bone-resident macrophages, endothelial cells and breast CCs. This minitissue recapitulates key features of the bone metastatic niche, including the alteration of macrophage polarization and microvascular architecture, along with the induction of CC micrometastases and osteomimicry. The minitissue reflects breast CC organ-specific metastatization to bone compared to a muscle minitissue. Finally, two FDA approved drugs, doxorubicin and rapamycin, have been tested showing that the dose required to impair CC growth is significantly higher in the MBm compared to a simpler CC monoculture minitissue. The MBm allows the investigation of metastasis key biological features and represents a reliable tool to better predict drug effects on the metastatic bone microenvironment.The synthesis of a sustainable material through carbon nitride (C3N4) chemically grafted on waste-derived carbon including carbonizing coals (PM), melamine-urea-formaldehyde resins (MUF-C-1100), and luffa cylindrical sponges (SG), respectively, and its application as sulfur cathode in lithium-sulfur (Li-S) batteries were demonstrated. The Li-S cell assembled by the sulfur (S) cathode with component from C3N4grafted coal-derived carbon (PM-CN) possesses a specific capacity of 1269.8 mA h g-1at 0.05 C. At 1 C, the initial specific capacity of PM cathode is only 380.0 mA h g-1, comparable to the PM-CN5 cathode of 681.9 mA h g-1, and PM-CN10 cathode of 580.7 mA h g-1, respectively. And, PM-CN 5 cathode presents the capacity retention of 75.9% with a coulomb efficiency (C.E.) of 97.3% after 200 cycles. The MUF-CN cathode gives a specific capacity of 1335.6 mA h g-1at 0.05 C, and the capacity retention of 66.7% with a C. E. of 93.6% after 300 cycles at 0.5 C. The SG-CN cathode had a specific capacity of 953.9 mA h g-1at 0.05 C, and capacity retention of 95.1% with a C. E. of 98.2% after 125 cycles at 1 C. The remarkable improved performances were mainly ascribed to the sustainable materials as S host with micro-meso pore and C3N4structure providing the strong affinity N sites to lithium polysulfides (LiPSs). This work provides an attractive approach for the preparation of sustainable materials by rational design of grafting C3N4to waste-derived carbons with functions as S cathode materials for high-performance Li-S batteries.The Most Likely Path formalism (MLP) is widely established as the most statistically precise method for proton path reconstruction in proton computed tomography (pCT). However, while this method accounts for small-angle Multiple Coulomb Scattering (MCS) and energy loss, inelastic nuclear interactions play an influential role in a significant number of proton paths. By applying cuts based on energy and direction, tracks influenced by nuclear interactions are largely discarded from the MLP analysis. In this work we propose a new method to estimate the proton paths based on a Deep Neural Network (DNN). Through this approach, estimates of proton paths equivalent to MLP predictions have been achieved in the case where only MCS occurs, together with an increased accuracy when nuclear interactions are present. Moreover, our tests indicate that the DNN algorithm can be considerably faster than the MLP algorithm.Objective.For patients with disorders of consciousness (DOC), such as vegetative state (VS) and minimally conscious state (MCS), communication is challenging. SBI-0206965 Currently, the communication methods of DOC patients are limited to behavioral responses. However, DOC patients cannot provide sufficient behavioral responses due to motor impairments and limited attention. In this study, we proposed a hybrid asynchronous brain-computer interface (BCI) system that provides a new communication channel for DOC patients.Approach.Seven DOC patients (3 VS and 4 MCS) and eleven healthy subjects participated in our experiment. Each subject was instructed to focus on the square with the Chinese words 'Yes' and 'No'. Then, the BCI system determined the target square with both P300 and steady-state visual evoked potential (SSVEP) detections. For the healthy group, we tested the performance of the hybrid system and the single-modality BCI system.Main results.All healthy subjects achieved significant accuracy (range from 72% to 100%) in both the hybrid system and the single-modality system. The hybrid asynchronous BCI system outperformed the P300-only and SSVEP-only systems. Furthermore, we employed the asynchronous approach to dynamically collect the EEG signals. Compared with the synchronous system, there was a 21% reduction in the average required rounds and a reduction of 105 s in the online experiment time. This asynchronous system was applied to detect the 'yes/no' communication function of seven DOC patients, and the results showed that three of the patients (3 MCS) showed significant accuracies (67 ± 3%) in the online experiment, and their Coma Recovery Scale-Revised (CRS-R) scores were also improved compared with the scores before the experiment. This result demonstrated that 3 of 7 patients were able to communicate using our hybrid asynchronous BCI system.Significance.This hybrid asynchronous BCI system represents a useful auxiliary bedside tool for simple communication with DOC patients.