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13 ± 8.32, 262.04 ± 7.15, 259.33 ± 7.31)ng/L VS (352.67 ± 19.24, 360.24 ± 23.58, 362.21 ± 25.24)ng/L] and TNF-α [(50.14 ± 1.75, 50.45 ± 1.81, 48.03 ± 1.24) ng/L VS (70.25 ± 3.02, 72.45 ± 3.25, 76.69 ± 2.18)ng/L] in CR + EC group were decreased (P  less then  0.0001). Compared with sham group, IL-6 [(343.76 ± 21.97, 345.91 ± 19.89, 340.34 ± 22.17)ng/L]and TNF-α [(68.10 ± 2.96, 67.31 ± 3.01, 70.34 ± 3.35)ng/L] of T3, T6 and T9 in CR + EC group were lower (P  less then  0.0001). These findings indicated that CRRT combined with low-flow ECMO of V-V mode had a positive effect on anti-inflammation, oxygenation improvement and surplus blood CO2 removal in canines with ARDS and hypercapnia. These results provide a promising treatment regimen for ARDS.Saxitoxin (STX) is a major marine toxin from shellfish, and it is responsible for paralytic shellfish poisoning (PSP). In this study, a highly sensitive and rapid aptamer assay was developed for STX detection by combining fluorescence resonance energy transfer (FRET) and nuclease-assisted target recycling signal amplification. 6-Diazo-5-oxo-L-norleucine The aptamer STX-41 conjugated with graphene quantum dots (GQDs) was adsorbed on magnetic reduced graphene oxide (MRGO) to establish a fluorescence quenching system. Then, the binding between STX and aptamer induced the desorption of GQD-aptamer from MRGO and the restoring of fluorescence for the fluorescent determination of STX. The digestion of the target bound aptamer by DNase I could release the target for recycling thus achieving signal amplification. Under the optimized conditions, the aptamer assay showed a wide detection range (0.1-100 ng·mL-1), low detection limit (LOD of 0.035 ng·mL-1), high specificity, good recovery (86.75-94.08% in STX-spiked clam samples) and repeatability (RSD of 4.27-7.34%). Combined with fluorescent detection technology, signal amplification technology, and magnetic separation technology, the proposed method can be used to detect STX in seafood products successfully.Water resources management requires a proper understanding of the status of available and exploitable water. One of the useful management tools is the use of simulation models that are highly efficient in spite of the complex problems in the groundwater sector. In the present study, three data-based models, namely, group method of data handling (GMDH), Bayesian network (BN), and artificial neural network (ANN), have been investigated to simulate the groundwater levels and assess the quantitative status of aquifers. Five observation wells were selected in Birjand aquifer using spatial clustering to analyze and evaluate the aquifer. To determine the effective variables in predicting groundwater level, 10 scenarios were developed by combining several variables, including groundwater level in the previous month, aquifer exploitation, surface recharge, precipitation, temperature, and evaporation. Results showed that the GMDH model with three input variables, i.e., the groundwater level in the previous month, aquifer exploitation, and precipitation, had the highest prediction performance, RMSE, NASH, MAPE, and R2 of which were obtained equal to 0.074, 0.97, 0.0037, and 0.97, respectively. Furthermore, Taylor's diagram showed that the predicted values using the GMDH model had the highest correlation with the observational data. Hydrograph simulation was performed for 6 years to analyze the condition of the aquifer. The results showed that the groundwater level is in critical condition in this aquifer, and a 1.2-m groundwater loss was predicted for this aquifer. The findings of this study show that the management of the studied aquifer is necessary to improve its current situation.Imaging techniques widely use Computed Tomography (CT) scans for various purposes, such as screening, diagnosis, and decision-making. Of all, it holds true for bone injuries. To build fully automated Computer-Aided Detection (CADe) and Diagnosis (CADx) tools and techniques, it requires fairly large amount of data (with gold standard). Therefore, in this paper, since state-of-the-art works relied on small dataset, we introduced a CT image dataset on limbs that is designed to understand bone injuries. Our dataset is a collection of 24 patient-specific CT cases having fractures at upper and lower limbs. From upper limbs, 8 cases were collected from bones in/around the shoulder (left and right). Similarly, from lower limbs, 16 cases were collected from knees (left and right). Altogether, 5684 CT images (upper limbs 2057 and lower limbs 3627) were collected. Each patient-specific CT case is composed of maximum 257 scans/slices in average. Of all, clinically approved annotations were made on every 10th slices, resulting in 1787 images. Importantly, no fractured limbs were missed in our annotation. Besides, to avoid privacy and confidential issues, patient-related information were deleted. The proposed dataset could be a promising resource for the medical imaging research community, where imaging techniques are employed for various purposes. To the best of our knowledge, this is the first time 5K+ CT images on fractured limbs are provided for research and educational purposes.

Cardiac hydatid over the interventricular septum is extremely rare. Echinococcus infests humans as an accidental host. Echocardiography usually clinches the diagnosis of cardiac hydatid. However, multimodality imaging including cardiac magnetic resonance (CMR) imaging, computed tomography (CT), and positron emission tomography (PET) helps in supporting the diagnosis and surgical planning.

We present a 29-year-old male who presented with dyspnea and was found to have cardiac hydatid on the interventricular septum on echocardiography. CT and CMR clinched the diagnosis. CT pulmonary angiography showed extensive pulmonary thromboembolization and cavitary consolidation in lungs. PET showed no active uptake in cardiac hydatid. Post-surgical enucleation of the cyst his hypotension worsened and succumbed.

Cardiac hydatid has poor prognosis. Multimodality imaging helps in confirming the diagnosis and surgical planning.

Cardiac hydatid has poor prognosis. Multimodality imaging helps in confirming the diagnosis and surgical planning.

Aneurysm of the left brachiocephalic vein is a very rare clinical disease and only 40 cases have been reported so far.

The patient was a 61-year-old woman with no related medical history. She underwent CT to investigate the cause of a cough and a mass was noted in the anterior mediastinum. Dynamic computed tomography with contrast medium injected into the left basilic vein demonstrated the venous aneurysm with blood flow to the left brachiocephalic vein. The patient had no symptoms, but because of the risk of pulmonary infarction and aneurysm rupture, the aneurysm was surgically resected. A median sternotomy was a reasonable approach because of the fragility of the venous aneurysm wall with little working space in the anterior mediastinum.

We diagnosed an aneurysm of the left brachiocephalic vein on preoperative imaging and excised it through a median sternotomy. The venous wall was thin and fragile in some areas and so this approach was appropriate in view of the possibility of intraoperative injury.

We diagnosed an aneurysm of the left brachiocephalic vein on preoperative imaging and excised it through a median sternotomy. The venous wall was thin and fragile in some areas and so this approach was appropriate in view of the possibility of intraoperative injury.This study aimed to evaluate the effects of different traditional or alternative energy and protein sources, associated or not, on feeding behavior, ruminal kinetics, and post-ruminal flow of nutrients. Besides, it was assessed diets' effects on different sites (reticulum and omasum) of buffaloes. Four ruminally cannulated male Murrah buffaloes (average initial weight of 637 ± 66.37 kg) were randomly distributed in a 4 × 4 Latin square design. Treatments were arranged as 2 × 2 factorial arrangement. The first factor evaluated was the inclusion of energy sources (ground corn and crude glycerin), and the second factor was the inclusion of protein sources (soybean meal and cottonseed cake). Buffaloes fed cottonseed cake had a higher content of neutral detergent fiber (NDF) and potentially digestible detergent fiber (pdNDF) in the rumen environment than buffaloes fed soybean meal. There was a sampling site effect on rumen digestion rates of pdNDF, passage rates of indigestible neutral detergent fiber (iNDF), and pdNDF, and flow of iNDF. In this study, omasal collections were more representative. Total replacement of ground corn by crude glycerin promoted less NDF ruminal digestibility, and care should be taken to include this energy source. The cottonseed cake does not cause a difference in rumen dynamics and can totally replace soybean meal in feedlot buffaloes' diet.Cercarial emission of schistosomes is a determinant in the transmission to the definitive host and constitutes a good marker to identify which definitive host is responsible for transmission, mainly in introgressive hybridization situations. Our goal was to test the hypothesis that micro-mammals play a role in Schistosoma haematobium, S. link2 bovis, and/or S. haematobium x S. bovis transmission. Small mammal sampling was conducted in seven semi-lacustrine villages of southern Benin. Among the 62 animals trapped, 50 individuals were investigated for Schistosoma adults and eggs 37 Rattus rattus, 3 Rattus norvegicus, 9 Mastomys natalensis, and 1 Crocidura olivieri. Schistosoma adults were found in four R. rattus and two M. link3 natalensis, with a local prevalence reaching 80% and 50%, respectively. Two cercarial chronotypes were found from Bulinus globosus experimentally infected with miracidia extracted from naturally infected M. natalensis a late diurnal and nocturnal chronotype, and an early diurnal, late diurnal, and nocturnal chronotype. The cytochrome C oxidase subunit I mtDNA gene of the collected schistosomes (adults, miracidia, and cercariae) belonged to the S. bovis clade. Eleven internal transcribed spacer rDNA profiles were found; four belonged to S. bovis and seven to S. haematobium x S. bovis. These molecular results together with the observed multi-peak chronotypes add M. natalensis as a new host implicated in S. haematobium x S. bovis transmission. We discuss the origin of the new chronotypes which have become more complex with the appearance of several peaks in a 24-h day. We also discuss how the new populations of offspring may optimize intra-host ecological niche, host spectrum, and transmission time period.

The Prognostic Nutritional Index (PNI), Nutritional Risk Index (NRI), Geriatric Nutritional Risk Index (GNRI), and Controlling Nutritional Status (CONUT) score were devised for quantifying nutritional risk. This study evaluated their properties in detecting compromised nutrition and guiding perioperative management of esophageal cancer patients.

A prospective institutional database of esophageal cancer patients was reviewed and analyzed. Compromised nutritional status was defined as PNI < 50, NRI < 97.5, GNRI < 92, or CONUT score ≥ 4, respectively. The malnutrition diagnosis consensus established by the European Society of Clinical Nutrition and Metabolism (ESPEN 2015) was selected as reference. Multivariable logistic regression and receiver operating characteristic curve analysis were used. External validation was conducted.

After reviewing the 212-patient database, 192 patients were finally included. Among the four nutritional indexes, the GNRI < 92 showed highest sensitivity (72.0%), specificity (78.