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9 nm and 110.6 nm for Cur NP+VC and CCNP+VC respectively. The curcumin encapsulated in the Cur NP+VC and CC+VC nano-scaffolds showed a release profile of > 60% and an improved antioxidant activity of greater than 80%. The nano-scaffolds were antagonistic against Escherichia coli and Staphylococcus aureus, and likewise enhanced wound healing capacity of 85.62 % and 77.05% was observed in murine cell line.
The curcumin nano-scaffold is a biodegradable and effective drug delivery system for topical use that can act as an antioxidant, facilitate wound healing, as well as prevent bacterial infections.
The curcumin nano-scaffold is a biodegradable and effective drug delivery system for topical use that can act as an antioxidant, facilitate wound healing, as well as prevent bacterial infections.
Coronavirus disease 2019 (COVID-19) is currently rampant worldwide, resulting in unpredictable harm to humans. High blood levels of cytokines and chemokines have been marked in patients with COVID-19 infection, leading to cytokine storm syndrome. Cytokine storms are violent inflammatory immune responses that reveal the devastating effect of immune dysregulation and the critical role of an effective host immune response.
Scientometric analysis summarizes the literature on cytokine storms in recent decades and provides a valuable and timely approach to tracking the development of new trends. This review summarizes the pathogenesis and treatment of diseases associated with cytokine storms comprehensively based on scientometric analysis.
Field distribution, knowledge structure, and research topic evolution correlated with cytokine storms are revealed, and the occurrence, development, and treatment of disease relevant to cytokine storms are illustrated.
Cytokine storms can be induced by pathogens and iatrogenic causes and can also occur in the context of autoimmune diseases and monogenic diseases as well. These reveal the multidisciplinary nature of cytokine storms and remind the complexity of the pathophysiological features, clinical presentation, and management. Overall, this scientometric study provides a macroscopic presentation and further direction for researchers who focus on cytokine storms.
Cytokine storms can be induced by pathogens and iatrogenic causes and can also occur in the context of autoimmune diseases and monogenic diseases as well. These reveal the multidisciplinary nature of cytokine storms and remind the complexity of the pathophysiological features, clinical presentation, and management. Overall, this scientometric study provides a macroscopic presentation and further direction for researchers who focus on cytokine storms.
The current framework is about heat and mass transformation of magnetic fluid flow having nanoparticles and motile microorganisms over a porous stretched sheet to examine the behavior of electric current aspects, heat radiation and activation energy.
Similarity transformations are applied to transform the highly mixed non-linear PDE's into higher order non-linear ODE's. Parametric equations with five dependent functions are resolved numerically by employing Bvp4c function of Matlab. The special types of boundary conditions are introduced, the velocity, temperature, concentration and motile microorganisms' profiles instigated strong deterioration to velocity slip, thermal slip as well as solutal slip of concentration and motile microorganisms with penetrability condition. Basic physical parameters i.e. temperature distribution, density, velocity field and motile micro-organism dispersions are being highly observed as influenced by emerging parameters.
The microorganisms disclose the decreasing behavior upon growing values of bio convection Lewis number and Peclet number. These results are highly useful in the application of heat transmitting equipment's as well as microbial fuel cells. Additionally, the behavior of Brownian motion, Rayleigh number, Bioconvection Lewis number thermophoresis parameter, Peclet number and buoyancy ratio factor are examined mathematically and visually. Moreover, the obtained outcomes are verified.
Physical quantities such as skin friction factor, heat flux, local Sherwood number and concentration number of motile microorganisms over speed field, heat coefficient, volumetric density of nanoparticles and microorganism concentration are briefly discussed in tabular and graphical form.
Physical quantities such as skin friction factor, heat flux, local Sherwood number and concentration number of motile microorganisms over speed field, heat coefficient, volumetric density of nanoparticles and microorganism concentration are briefly discussed in tabular and graphical form.Favipiravir is a potential antiviral drug undergoing clinical trials to manage various viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Favipiravir possesses antiviral properties against RNA viruses, including SARS-CoV-2. Unfortunately, these viruses do not have authorized antiviral drugs for the management of diseases resulting from their infection, hence the dire need to accentuate the discovery of antiviral drugs that are efficacious and have a broad spectrum. Favipiravir acts primarily by blocking inward and outward movements of the virus from cells. Favipiravir is a prodrug undergoing intracellular phosphorylation and ribosylation to form an active form, favipiravir-RTP, which binds viral RNA-dependent RNA polymerase (RdRp). Considering the novel mechanism of favipiravir action, especially in managing viral infections, it is vital to pay more attention to the promised favipiravir hold in the management of SARS-CoV-2, its efficacy, and dosage regimen, and interactions with other drugs. In conclusion, favipiravir possesses antiviral properties against RNA viruses, including COVID- 19. Favipiravir is effective against SARS-CoV-2 infection through inhibition of RdRp. Pre-clinical and large-scalp prospective studies are recommended for efficacy and long-term safety of favipiravir in COVID-19.Background Gastrointestinal cancer (GIC) is a prevalent and lethal malignant tumor. It is obligatory to investigate innovative biomarkers for the diagnosis and prognosis. Proteins play a crucial role in regulating the occurrence and progression of GIC. However, the prognostic value of proteins is unclear in GIC.
This paper aims to identify the hub prognosis-related proteins (PAPs) and construct a prognosis model to GIC patients for clinical application.
Protein expression data of GIC were obtained from The Cancer Proteome Atlas (TCPA) and downloaded the clinicopathological data from The Cancer Genome Atlas database (TCGA). Besides, hub proteins were filtrated out via univariate and multivariate Cox regression analysis. Moreover, survival analysis and nomogram were used to predict overall survival (OS). We used the calibration curves to assess the predictive and actual survival rate consistency. The consistency index (C-index) was used to evaluate the prognostic ability of the predictive model. Furthermore,esides, several PAPs, associated with the survival and clinicopathological characteristics of GIC might be potential biomarkers for GIC diagnosis and treatment.
The results indicate that the risk score is an independent prognostic biomarker and is related to the malignant clinical features of GIC patients. Besides, several PAPs, associated with the survival and clinicopathological characteristics of GIC might be potential biomarkers for GIC diagnosis and treatment.
Age-related impairments in macrophage functions have important consequences for the health of the elderly population. The aging process is also accompanied by a reduction in several hormones, including growth hormone (GH). Previous studies have shown that this hormone can affect macrophage activity in young individuals; however, the biological effects of GH stimulation on macrophages during aging have not yet been elucidated.
The aim of this work was to investigate the in vitro effects of GH on peritoneal macrophages from aged mice.
Peritoneal macrophages isolated from young (4 months-old) and old (12-15 months-old) mice were treated in vitro with 100 ng/mL of GH for 24 hours. After treatment, cells were analysed for cell morphology, reactive oxygen species (ROS) production, expression of integrins, cell adhesion to extracellular matrix molecules, and migration in transwell chambers.
Although GH-treated cells from old mice exhibited decreased ROS production, we did not observe the effects of GH on macrophage morphology or macrophage phagocytic activity in young and old mice-derived cell cultures. Macrophages from old mice had increased adhesion to laminin and fibronectin substrates, as did cells obtained from young mice treated with GH, but no change was observed in the expression of integrin receptors. find more Furthermore, cells from old mice exhibited increased migration compared to young mice and a significant increase in macrophage migration was observed under GH stimulation.
Our results showed that GH can interfere with the motility of macrophages from old mice, advancing our understanding of the interactions between the immune and neuroendocrine systems during aging.
Our results showed that GH can interfere with the motility of macrophages from old mice, advancing our understanding of the interactions between the immune and neuroendocrine systems during aging.
Frailty is a state of age-related physiological vulnerability resulting from impaired homeostatic reserve and a reduced capacity of the individual to withstand stress and an independent predictor of deleterious health outcomes among the aged. Early identification of people who are at risk for frailty is vital in prevention and minimizing its socio-economic consequences in low-resource countries like India. However, risk factors for frailty among Indian institutionalized older adults have been seldom explored.
To develop a prediction model for the risk of frailty among institutionalized older adults Method This study adopted a case-control design, wherein institutionalized adults were categorized into frail and non-frail, using Fried's criteria. Individuals above 55 years of age, who could follow instructions; without severe motor and cognitive impairment and terminal illness were recruited from nine conveniently selected institutions. Socio-demographic, lifestyle, behavioral, and; physical performance facitutionalized older adults.
Orchids are widely used in floriculture as attractive cut flowers all over the world. The current paper reviews factors affecting the in vitro flowering in orchid species.
The phenomenon of in vitro flowering is advantageous as it shortens the breeding cycle, which is prolonged in the in vivo grown orchid species of commercial value. Certain genetic and biochemical mechanisms are involved at the time of onset of flowering in orchid plants. In the present endeavour, efforts have been made to initiate in vitro flowering in terrestrial and epiphytic orchid species. Various phenomenon involved during transition of vegetative shoot apex into floral axis is also reviewed.
In vitro flowering was induced in Dendrobium nobile and Zeuxine strateumatica in Mitra medium supplemented with BAP at 0.5 in mgl
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In vitro flowering can be initiated by manipulating physical and chemical stimulus in the nutrient regime. The study would be helpful in better understanding the complex process of flowering in vitro as well as ex vitro.
