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997) and Freundlich model (R2 = 0.993), respectively, this indicated that the adsorption of lead ion occurs within the pores and via the functional groups present on the nanocomposite.The Basil seeds mucilaginous polysaccharide exhibits remarkable physical and chemical properties like high water-absorbing capacity, emulsifying, and stabilizing properties. The metal-organic frameworks are one of the most promising precursors made of metal clusters and organic connectors for the fabrication of advanced adsorbents due to their unique properties. In this study, the bionanocomposite of magnetic zeolitic imidazolate framework-8 was successfully synthesized and applied to adsorb azo cationic and anionic dyes. The synthesized magnetite nanoparticles were pretreated with mucilage extracted from basil seeds to acquire negatively charged magnetite surface, followed by nucleation through attracting zinc cation, and then the growth of metal-organic frameworks which yields high-quality ZIF-8 crystals. The samples were characterized by Field Scanning Electron Microscopy, X-ray Diffraction, Fourier Transform Infrared Spectrometry, vibrating sample magnetometer, and Brunauer-Emmett-Teller surface area analysis. In the process of adsorption, influencing factors and recycling regeneration were discussed, and the adsorption mechanisms such as kinetics, isotherm, and thermodynamics were explored. The results of the adsorption process showed that maximum adsorption capacities were 9.09 and 13.21 mg/g for Methylene blue and Eriochrome Black T, respectively. The excellent reusability combined with its magnetic separation property makes the nanocomposite a promising adsorbent for the removal of cationic and anionic dyes.Kraft lignin, so far useful for energy generation, has been gathering considerable attention as an alternative material to replace fossil-based resources mainly due to its high phenolic content. However, the wide molecular weight distribution and chemical composition heterogeneity led to the development of fractionation methods. Herein, to narrow such characteristics we used eucalypt kraft lignin fractionated at pH's 9, 7, 5 and 3 by sequential acid precipitation. These lignin fractions were first characterised by simultaneous pyrolysis and trimethylsilylation (SPyT) with N-Methyl-N-(trimethylsilyl) trifluoroacetamide with posterior tests of antioxidant, antibacterial, and antitumour activities. We observed higher ratio of syringyl/guaiacyl groups and increase in antioxidant activity in those fractions with lower molecular weight (precipitated at lower pH's). Fractions precipitated at pH's 9 and 7 have shown an outstanding antibacterial activity against five bacteria. Moreover, fractions 7 and 5 presented at cytotoxicity tests higher ability to inhibit the growth of U87MG and T98G glioma cells, while only a slight inhibition of adult human fibroblasts (non-tumour cells) was detected."Nanocellulose" have captivated the topical sphere of sturdily escalating market for sustainable materials. The review focuses on the comprehensive understanding of the distinct surface chemistry and functionalities pertaining to the renovation of macro-cellulose at nanodimensional scale to provide an intuition of their processing-structure-function prospective. The abundant availability, cost effectiveness and diverse properties associated with plant-based resources have great economical perspective for developing sustainable cellulose nanomaterials. Hence, emphasis has been given on nanocellulose types obtained from plant-based sources. An overarching goal is to provide the recent advancement in the preparation routes of nanocellulose. Considering the excellent shear thinning/thixotropic/gel-like behavior, the review provids an assemblage of publications specifically dealing with its application as rheology modifier with emphasis on its use as bioink for 3D bioprinting for various biomedical applications. Altogether, this review has been oriented in a way to collocate a collective data starting from the historical perspective of cellulose discovery to modern cellulosic chemistry and its renovation as nanocellulose with recent technological hype for broad spanning applications.The research work was intended to formulate teriflunomide (TFM) loaded nano lipid-based (TNLC) carbopol-gellan gum in situ gel (TNLCGHG) and to investigate its therapeutic efficacy against glioma, a brain and spine tumor. Nanoformulation was developed using gellan gum and carbopol 974P as gelling and mucoadhesive agents, respectively, Glyceryl di-behenate and Glyceryl mono-linoleate blend as lipids, and Gelucire 44/14 water blend as surfactant system. Globule size, PDI, zeta potential, encapsulation efficiency, mucoadhesive strength, and nasal permeation were found to be 117.80 nm, 0.56, -21.86 mV, 81.16%, 4.80 g, and 904 μg/cm2, respectively. Anticancer efficacy of TFM-loaded nano lipid-based carbopol-gellan gum in situ gel (TNLCGHG) was determined in human U-87MG glioma cell line. IC50 was found 7.0 μg/mL for TNLCGHG, 4.8 μg/mL for pure TFM, and 78.5 μg/mL for TNLC, which approve the superiority of surfactant along with gellan gum as permeation enhancer. Brain Cmax for technetium (99mTC) labeled intranasal (i.n.) 99mTC-TNLCGHG was found 2-folds higher than 99mTC-TNLC (i.n.) and 99mTC-TNLC intravenous (i.v.) because the TNLCGHG formulation contains surfactant with natural gelling polymers, which promisingly improved drug permeability. Finally, this research revealed encouraging outcomes and successfully developed intranasal TNLCGHG nanoformulation as a novel tool for safe delivery of TFM in glioma patients.In this study, novel 3D porous alginate-coated 58S bioactive glass scaffolds were fabricated through a foam replication method using a combination of amorphous 58S bioactive glass structure and sodium alginate. The formation of the alginate coating on the surface of the struts of BG scaffolds was confirmed. The effect of alginate coating on the microstructure, mechanical properties, biodegradability, biomineralization, adhesion, viability, and differentiation of human bone marrow-derived mesenchymal stem cells (hMSCs) on the 58S BG scaffolds were evaluated. A 45.2% increase in hMSC's viability and a 3.4-fold increase in ALP activity of the 1AlBG scaffold in the absence of an osteogenic differentiation media compared to an uncoated BG scaffold were observed. Notably, gene expression analysis exhibited that the 1AlBG scaffold resulted in accelerated osteogenic differentiation of hMSCs, as expression of COL-1, RUNX2, and OCN increased after 14 days. Results revealed a significant increase of antibacterial inhibition in the 1AlBG scaffold in comparison to the BG scaffold. Based on the microstructural, mechanical, and biological investigations, the 1AlBG scaffold exhibited enhanced mechanical and biological properties, making it a promising candidate for bone regeneration. Overall, our findings have highlighted the potential of alginate-coated BG scaffolds to stimulate bone regeneration through stem cell osteoinduction.Conductive self -electrical stimuli bioactive scaffolds could be used the potential for peripheral nerve regeneration with the maximum efficiency. To produce such conductive self-electrical stimuli bioactive scaffolds, chopped spun piezoelectric nanofibers of polyvinylidene fluoride/mesoporous silica nanoparticle (PVDF/MCM41) are prepared and incorporated in gellan/polyaniline/graphene (gellan/PAG) nanocomposites which have been previously prepared by incorporation of polyaniline/graphene (PAG) nanoparticles in gellan gel at 80 °C. Highly conductive binary doped polyaniline/graphene nanoparticles are prepared by chemical oxidative polymerization of aniline monomer using in-suite precipitation polymerization method in presence of graphene nanoparticles and sodium dodecyl sulfate. All intermediate and final products including spun PVDF/MCM41 nanofibers, PAG nanoparticles, and gellan-gelatin gel scaffolds containing PVDF/MCM41 nano spun fibers and PAG nanoparticles are characterized using different analysis methods. Chemical and structural analyses of PAG nanoparticles and PVDF/MCM41 nanofibers have been done using FTIR and XRD methods. The morphological structure of different samples is investigated using SEM. Morphological investigation and DLS results confirm fabrication of MCM41 nanoparticle with a completely spherical shape and the average size of 50 nm of which have been dispersed in electrospun PVDF nanofibers very well. read more Also, the preparation of PAG nanoparticle with high conductivity is verified with morphological and conductivity tests. MTT easy and biocompatibility test results indicate potential applicability of the prepared conductive self -stimuli nano-scaffold for nerve regeneration applications.Sr3.8Fe25.7O70.4-chitosan magnetic microparticles (Sr3.8Fe25.7O70.4-CMNs) with a core-shell structure were synthesized, characterized and applied for the removal of two model cationic dyes. The results showed that these magnetic microparticles possess fast adsorption rate and high adsorption efficiency for both crystal violet (CV) and basic red 9 (BR9) at a temperature ranging 30 °C to 40 °C and suitable pH range (pH ≥ 7). The maximum removal efficiency for CV and BR9 attained to 94.5% and 97.5% in 30 min, which was significantly faster and higher than that of chitosan ( 0.97) and the pseudo-second-order model. Additionally, the synthesized Sr3.8Fe25.7O70.4-CMNs were easy to regeneration and reuse, and the removal rate remained above 90% after 5 recycle times. This study would provide a new more environmental friendly material and method for the treatment of wastewater containing toxic dyes.Enzymes are the highly versatile bio-catalysts having the potential for being employed in biotechnological and industrial sectors to catalyze biosynthetic reactions over a commercial point of view. Immobilization of enzymes has improved catalytic properties, retention activities, thermal and storage stabilities as well as reusabilities of enzymes in synthetic environments that have enthralled significant attention over the past few years. Dreadful efforts have been emphasized on the renewable and synthetic supports/composite materials to reserve their inherent characteristics such as biocompatibility, non-toxicity, accessibility of numerous reactive sites for profitable immobilization of biological molecules that often serve diverse applications in the pharmaceutical, environmental, and energy sectors. Supports should be endowed with unique physicochemical properties including high specific surface area, hydrophobicity, hydrophilicity, enantioselectivities, multivalent functionalization which professed them as competent carriers for enzyme immobilization. Organic, inorganic, and nano-based platforms are more potent, stable, highly recovered even after used for continuous catalytic processes, broadly renders the enzymes to get efficiently immobilized to develop an inherent bio-catalytic system that displays higher activities as compared to free-counter parts. This review highlights the recent advances or developments on renewable and synthetic matrices that are utilized for the immobilization of enzymes to deliver emerging applications around the globe.