Hintonwang0968

The density functional theory (DFT) calculations uncover that Zn(II) ions can efficiently activate both C≡C bonds of propargylic amines and CO 2 by coordination interaction, forming quite short Zn-O bonds and bent configuration with bond angle of 167.2°. NMR and FTIR spectroscopy further prove that Zn-clusters play an important role in activating C≡C bonds of propargylic amines. Furthermore, the electronic properties of related reactants, intermediates and products can help to understand the basic reaction mechanism and crucial role of catalyst 1 . © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.Chaos and natural evolution of tumor system have become two reasons of the failure of tumor therapies. Selectively targeting chaotic tumor systems to induce a "butterfly effect" is promising in constructing non-interventional and effective strategy for tumor therapy. Herein, we demonstrate for the first time that iridium oxide nanoparticles (IrO x ) possess acid-activated oxidase and peroxidase-like functions and wide pH-dependent catalase-like properties. Integrating of glucose oxidase (GOD) could unlock its oxidase and peroxidase activities by gluconic acid produced by catalysis of GOD towards glucose in cancer cells, and the produced H 2 O 2 can be converted to O 2 to compensate its consumption in GOD catalysis due to the catalase-like function of the nanozyme, which result in continual consumption of glucose and self-supplied substrates for generating superoxide anion and hydroxyl radical. Moreover, IrO x can constantly consume glutathione (GSH) by self-cyclic valence alteration of Ir (IV) and Ir (III), greatly reducing the anti-oxidation defense effect of tumor. Consequently, these self-cyclic parallel cascaded reactions due to the introduction of IrO x -GOD into chaotic tumor lead to a "butterfly effect" of initial starvation therapy and subsequent multiple reactive oxygen species (ROS) pressure, completely break the self-adaption of cancer cells compared to traditional ROS- and GSH- targeted therapies, providing new conceptual thinkings for non-interventional and precise cancer therapy against the resistance. © 2020 WILEY-VCH Verlag GmbH & Co. Olaparib KGaA, Weinheim.OBJECTIVES A national pre-registration pharmacist recruitment scheme, which replaces the local recruitment models, was introduced in England and Wales in 2017. This study aimed to explore pharmacy students' behaviour and associated factors in their selection of pre-registration training programmes. METHODS A mixed-method study using (a) analysis of data from all applicants (n = 2694) of the national recruitment scheme, (b) an online survey and (c) a virtual focus group was undertaken. Survey and focus group questions were developed based on the Theoretical Domains Framework (TDF). Descriptive and inferential analysis of quantitative data was undertaken using Stata software. Qualitative data from focus groups and responses from the open-ended questions were analysed using framework technique. KEY FINDINGS A vast majority of applicants (n = 2182, 83.9%) selected a hospital training programme as their first ranked preference, with the rest opting for community pharmacy. Urban areas, particularly London, were most popular geographically. A total of 307 survey responses were returned. Long-term career aspirations, followed by geographical factors, were rated most highly in applicants' decision-making. Qualitative data from survey and focus group demonstrated information about programmes/employers, perceived opportunity for skills development and aspiration towards a career path as key contributory factors in their decision-making. CONCLUSIONS Secondary care was the most desirable destination for pharmacy students to undertake early career training. The clinical roles and career opportunities in community pharmacy needs to be promoted as there is a risk that community pharmacy training programme places may be seen as a 'left over' opportunity for less competitive candidates to uptake. © 2020 Royal Pharmaceutical Society.OBJECTIVE To investigate the correlation between hTREC and human papillomavirus (HPV) load and cervical intraepithelial neoplasia (CIN) grade II/III lesions and cervical cancer. METHODS A total of 135 patients with cervical lesions of different degrees admitted to our hospital from January 2016 to February 2017 were selected, including CIN I/III 65 cases, grade III 39 cases, and cervical cancer 31 cases. The expression of hTERC gene was detected by fluorescence in situ hybridization (FISH) in three groups, and the HPV load was detected by second-generation hybridization capture (HC II) method, and its relationship with cervical lesion grade was analyzed. Department. RESULTS The positive expression rate of hTERC gene amplification was cervical cancer > CIN I/II lesion > CIN III lesion; the positive expression rate of HPV was cervical cancer > CIN I/II lesion > CIN III lesion. After treatment, the positive rate of hTERC gene amplification and HPV expression decreased significantly within 1 year (P  less then  .05). Spearman's analysis showed that the degree of cervical lesion was positively correlated with hTREC and HPV load (P  less then  .05). CONCLUSION hTREC and HPV are closely related to the occurrence and development of cervical precancerous lesions and cervical cancer. The abnormal amplification of hTERC gene increases with the grade of cervical lesions. Both of them can be used as auxiliary indicators for early screening, treatment, and prognosis of cervical cancer. © 2020 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals, Inc.AIM To report the activity of the Otorhinolaryngology Research Society (ORS) from its' founding in 1978 until dissolution in 2017. METHOD Data was obtained, (Minutes of Council Meetings, and Correspondence) from the Societies web site (now closed and archived), and relevant documents and e-mails that pervious secretaries and treasurers of ORS and The British Society of Academics in Otolaryngology (BSAO) had available. The secretarial documents of the ORS, the first 20 years had been reported "lost" and the data retained on web site was incomplete. ETHICAL CONSIDERATION No patient data have been used in this publication. RESULTS The first constitution of ORS was based on that of the Surgical Research Society and was brief and simple, with two meetings per year, awarding prizes and bursaries for the best presentations. The Society initially limited to 250 members. The constitution of ORS was revised in 1988 and modified again in 2006 which expanded the council and disbanded the need for membership. CONCLUSION The changing priorities of trainees and commercialisation of the National Health Service had resulted in running any society costly.