Hauserlarkin8861

This review is conducted to identify knowledge gaps regarding the broad spectrum of clinical signs and symptoms of children with COVID -19.

To investigate the similarities and differences of renal clinical and renal pathology between IgA nephropathy (IgAN) and IgA Vasculitis Nephritis (IgAVN) in children.

A total of 237 children with IgAN and 190 children with IgAVN were included. The general conditions, clinical characteristics, final diagnosis, clinical and pathological classification of the children were intercepted at the time of admission, and the retrospective comparative analysis was carried out.

The results showed that the median course of disease in IgAN group was longer than that in IgAVN group (P=0.02). Patients with IgAN had a significantly higher duration of infection than the patients with IgAVN (P=0.03). The white blood cell count (WBC), hemoglobin (HGB) in IgAN group were significantly lower than that in IgAVN group (P=0.02). The serum creatinine in IgAN group was higher than that in IgAVN group (P=0.02). Patients with IgAN and IgAVN had statistically significant differences in pathological typing between clinical types hematuria and proteinuria, nephrotic syndrome and chronic nephritis (P=0.004).

The clinical manifestations of IgAN and IgAVN were similar, but the onset of IgAN was hidden and the clinical manifestations were relatively serious. Renal pathology was mainly glomerulosclerosis and renal tubular atrophy. IgAVN was characterized by acute onset and good renal function. Renal pathology was dominated by endothelial hyperplasia and crescent formation. These differences did not support the hypothesis that the two diseases are the same.

The clinical manifestations of IgAN and IgAVN were similar, but the onset of IgAN was hidden and the clinical manifestations were relatively serious. Renal pathology was mainly glomerulosclerosis and renal tubular atrophy. IgAVN was characterized by acute onset and good renal function. Renal pathology was dominated by endothelial hyperplasia and crescent formation. These differences did not support the hypothesis that the two diseases are the same.

The aim of this study is to determine the mutation spectrums and clinical characteristics of NF1 patients followed up in our center and to investigate whether there is a genotype-phenotype relationship.

Sixty-three children and 34 relatives diagnosed with NF1 were included in the study. Age, gender, family history, clinical features, tumors detected in the patient at the time of diagnosis or during follow-up, orbital and cerebral magnetic resonance imaging (MRI) findings were recorded. Also results of the NF1 gene analysis results were recorded.

Fifty-three different mutations were found as a result of the NF1 gene analysis studied from patients and their family members. Among these 53 mutations, stop codon mutation was the most frequently detected mutations. Sixteen out of 50 (32%) mutations were found to be novel mutations. Twenty-eight tumors developed in our patients. Twenty of them were optic gliomas and others were medullary thyroid carcinoma, glioblastome multiforme, pons glioma, acute lymphoblasdifferent phenotypic characteristics even in the same mutation.----.Background Prior observational studies have reported that higher levels of vitamin D are associated with decreased caries risk in children. However, these studies are prone to bias and confounding so do not provide causal inference. Genetic variants associated with a risk factor of interest can be used as proxies, in a Mendelian randomization (MR) analysis, to test for causal association with an outcome. The objective was to estimate the causal association between serum 25-hydroxyvitamin D (25(OH)D) (the commonly measured vitamin D metabolite in blood) and dental caries using a two-sample MR approach which estimates the causal effect of an exposure on an outcome. Methods A total of 79 genetic variants reliably associated with 25(OH)D were identified from genome-wide association studies and used as a proxy measure of 25(OH)D. The association of this proxy measure with three outcome measures was tested; specifically caries in primary teeth (n=17,035, aged 3-12 years), caries in permanent teeth in childhood and adolescence (n=13,386, aged 6-18 years), and caries severity in adulthood proxied by decayed, missing and filled tooth surfaces (DMFS) counts (n=26,792, aged 18-93 years). Results The estimated causal effect of a one standard deviation increase in natural log-transformed 25(OH)D could be summarized as an odds ratio of 1.06 (95%CI 0.81, 1.31; P=0.66) for caries in primary teeth and 1.00 (95%CI 0.76, 1.23; P=0.97) for caries in permanent teeth in childhood and adolescence. In adults, the estimated casual effect of a one standard deviation increase in natural log-transformed 25(OH)D was 0.31 fewer affected tooth surfaces (95%CI from 1.81 fewer DMFS to 1.19 more DMFS; P=0.68) Conclusions The MR-derived effect estimates for these three measures are small in magnitude with wide confidence intervals and do not provide evidence for a causal relationship between 25(OH)D and dental caries.

COVID-19 has trickle down effects psychologically on multiple strata of society, particularly university students. Apart from the worry of contracting or spreading COVID-19, Malaysian university students were also locked down in campuses, suffering significant psychological distress. EPZ011989 nmr Hence, an online mindfulness intervention was proposed to alleviate psychological distress and improve psychological flexibility and mindfulness.

The study was a quasi-experimental study, with university students as participants. Intervention group participants were instructed to fill up online questionnaires which included basic demographics, as well as instruments assessing depression, anxiety, stress, mindfulness, psychological flexibility and fear of COVID-19 before and after the one-hour intervention. The control group completed pre- and postquestionnaires then subsequently crossed over to the intervention group. Repeated measures ANOVA was performed to assess time*group effects.

118 participants were involved in this nd fear of COVID-19 showed no difference. Results of this study corroborates the efficacy of online single session mindfulness therapy as a viable short-term psychological intervention amidst financial and time constraint. As university students are in the age group of highest incidences of depressive and anxiety disorders, it is crucial to utilize resources to address as many students as possible to ensure maximal benefit.

Breast cancer is the most common cancer in women worldwide. Many of these patients suffer from multiple psychological symptoms. The present study aimed to investigate the impact of acceptance and commitment therapy (ACT) on depression, pain acceptance, and psychological flexibility in married women with breast cancer.

The present study was a pre- and post-test clinical trial with intervention and control groups. The research population consisted of women with breast cancer referred to the Ayatollah Yasrebi and Shahid Beheshti Hospitals in Kashan in 2018. Through a purposive sampling method, 40 women were selected and randomly divided into two groups, namely, intervention (n = 20) and control (n = 20). The applied tools included the Depression, Anxiety and Stress Scale (DASS-21), Chronic Pain Acceptance Questionnaire 8 (CPAQ-8), and Acceptance and Action Questionnaire - II (AAQ-II). Data were analyzed by SPSS 16 using descriptive statistics and analysis of variance (ANOVA).

The results showed that ACT treatment significantly reduced the mean scores of depression compared to the control group (F = 107.72, p < 0.001). The mean scores of pain acceptance (F = 9.58, p < 0.05) and psychological flexibility (F = 10.61, p < 0 .05) significantly increased in comparison with the control group.

ACT can be considered as an effective therapeutic approach to reduce depression and increase pain acceptance and psychological flexibility in women with breast cancer. These changes appear to be due to improved acceptance of thoughts and feelings associated with cancer and increased psychological flexibility, which is the primary goal of ACT treatment.

Iranian Registry of Clinical Trials (IRCT), IRCT20190518043620N1.

Iranian Registry of Clinical Trials (IRCT), IRCT20190518043620N1.

There are several negative impacts on the physical and mental health of people presenting internet addiction, especially for the development of mood disorders, such as depression.

The aim of the study was to evaluate the association between internet addiction and depressive symptoms, as well as to test the mediating role of physical activity in this association.

A cross-sectional study was conducted among undergraduate students from three universities (one private and two public institution) from southern Brazil. Depressive symptoms were measured with the Beck Depression Inventory (BDI-21), internet addiction with the Internet Addiction Test (IAT-20) and physical activity was assessed with the International Physical Activity Questionnaire (IPAQ - short version). Poisson regression and the Karlson-Holm-Breen mediation method were used to the statistical analyses.

We have observed a dose-response relation between internet addiction and depressive symptoms. Levels of physical activity mediated the association between moderate internet addiction and depressive symptoms, accounting for 10.7% of the effect observed.

Internet addiction can be detrimental to individuals' health, and contribute to the development of depressive symptoms. Along with psychological and pharmacological therapies, prescription of physical activities are recommended.

Internet addiction can be detrimental to individuals' health, and contribute to the development of depressive symptoms. Along with psychological and pharmacological therapies, prescription of physical activities are recommended.

Bipolar disorder (BD) has a high heritability rate. Current studies have been dedicated to identifying prodromes of BD in the offspring of parents with BD (BO), and the sleep patterns of these individuals have been considered important factors.

To describe the changes in sleep parameters among offspring of parents with BD when compared to offspring of controls and to identify if changes in parameters and quality of sleep predict the onset of BD among these individuals.

PubMed, PsycINFO, and Embasewere systematically searched with no year or language restrictions, up to August 18, 2020. We searched for a combination of the following search items ("sleep*") AND ("bipolar disorder*" OR "mania" OR "hypomania" OR "bipolar depression") AND ("ultra-high risk" OR "high risk" OR "offspring" OR "first degree relatives").

A total of 10 studies were included in the systematic review and 4 studies were included in the meta-analysis. Our meta-analysis showed that the BO showed greater daytime sleepiness as compared to the offspring of control parents. The systematic review indicates that shorter sleep duration, sleep disorders and other related features can differentiate the two groups. Finally, some sleep patterns such as decreased sleep, difficulty falling asleep, and overall sleep problems might be predictors for the development of BD.

To describe the changes in sleep parameters among offspring of parents with BD when compared to offspring of controls and to identify if changes in parameters and quality of sleep predict the onset of BD among these individuals.

To describe the changes in sleep parameters among offspring of parents with BD when compared to offspring of controls and to identify if changes in parameters and quality of sleep predict the onset of BD among these individuals.