Hassingballe5081
85 and 0.69, respectively. The AUC of PCT on POD 5 had a value of 0.87, with a sensitivity and specificity of 0.84 and 0.74, respectively.
Our research supports the hypothesis that CRP and PCT are valuable diagnostic tools for predicting POPF, especially given the CRP levels on POD 4 and PCT levels on POD 5. Limited by the small number of the studies analyzed herein, we recommend that more randomized controlled trials be performed to verify our conclusions.
Our research supports the hypothesis that CRP and PCT are valuable diagnostic tools for predicting POPF, especially given the CRP levels on POD 4 and PCT levels on POD 5. Limited by the small number of the studies analyzed herein, we recommend that more randomized controlled trials be performed to verify our conclusions.
The most common complication of thyroid anesthesia is recurrent laryngeal nerve injury, and anesthesia drugs affect the intraoperative recurrent laryngeal nerve monitoring indicators, especially nerve blockers, which can cause muscle relaxation and affect vocal cord contraction. The purpose of this study was to investigate the optimal dose of rocuronium during general anesthesia (GA) during thyroid surgery by meta-analysis.
Chinese and English databases were searched by the combination of "thyroid", "general anesthesia", and "rocuronium bromide". Publications which took double dose rocuronium GA surgery as the double group and normal dose rocuronium GA surgery as the normal group were included, and Review Manager 5.3 (Rev Man 5.3) was employed for meta-analysis.
A total of fifteen publications were included in the meta-analysis and an overall heterogeneity test was conducted to obtain the results. Comparison of the operation time between the double group and the normal group showed the mean difference (firmed that a double dose of rocuronium can meet the needs of anesthesia induction and GA during thyroid surgery.
This meta-analysis confirmed that a double dose of rocuronium can meet the needs of anesthesia induction and GA during thyroid surgery.
There are many types of neurosurgery devices, their manipulation procedures are complex, and it is difficult for growing nurses in operating room to use them proficiently. In clinical practice, a set of detailed, intuitive, and flexible training methods are needed to improve the effectiveness of training for growing nurses in operating room. In this study, a two-dimensional (2D) code video was used to train growing nurses in operating room to operate these devices, aiming to improve their ability to do so in the clinical setting.
Before training, we created a video for every step of device manipulation, decoded the videos, generated a 2D code respectively, and scanned the code to play on a personal digital assistant (PDA). In 2019, we enrolled 32 growing nurses at the N1 level (N1 refers to the lowest level of nurses) in the north and south divisions of our hospital. A total of 16 nurses from the south division were trained with traditional methods, and 16 nurses from the north division were trained based devices.
Although the mortality of pancreaticoduodenectomy (PD) has decreased, the morbidity especially infections is still a severe challenge. This study aimed to identify the risk factors and microbial spectrum for infectious complications after PD.
This retrospective study of 291 consecutive patients who underwent PD between February 2018 and March 2021 was conducted. The clinical data was reviewed and risk factors associated with infectious complications were analyzed. To investigate the microbial spectrum, microorganisms isolated from preoperative bile, drainage fluid and blood were counted.
A total of 110 patients (37.8%) developed postoperative infections. The patients who suffered infections had higher severe complications, prolonged hospitalization and increased expenditures. Three independent risk factors were identified preoperative biliary drainage (PBD) [odds ratio (OR) 2.082; 95% confidence interval (CI) 1.059-4.091; P=0.033], clinically relevant postoperative pancreatic fistula (CR-POPF) (OR 11.984; 95% CI 6.556-21.471; P=0.000) and biliary fistula (BF) (OR 3.674; 95% CI 1.218-11.084; P=0.021).
and
were the most frequently isolated bacteria in preoperative bile and drainage fluid after PD.
and
were the most common bacteria in bacteremia patients.
PBD, POPF and BF are independent risk factors for infectious complications after PD. To lower the incidence of infection, PBD should be performed only in select cases and efforts should be taken to reduce the POPF and BF. The pathogens of bile and drainage fluid should be monitored throughout the hospital stay.
PBD, POPF and BF are independent risk factors for infectious complications after PD. To lower the incidence of infection, PBD should be performed only in select cases and efforts should be taken to reduce the POPF and BF. The pathogens of bile and drainage fluid should be monitored throughout the hospital stay.
To verify the feasibility of using the residual cancer burden (RCB) index to stratify prognosis of patients after neoadjuvant chemotherapy (NAC) and to compare RCB with the Miller-Payne system.
We retrospectively analyzed clinicopathological data of patients receiving treatment between January 1, 2010 and December 31, 2018. Kaplan-Meier curves were used to compare the survival outcomes and estimate disease-free survival (DFS) and disease-specific survival (DSS). Harrell's concordance index (C-index) was used to evaluate the predictive accuracy of RCB and Miller-Payne system.
A total of 423 female patients with complete data were included in the analysis, with a median follow-up time of 58.5 months (range, 7-126 months); 84 patients experienced recurrence, and 48 experienced breast cancer related death. RCB index and the Miller-Payne system were associated with prognosis in the whole cohort. Patients who achieved RCB-I had similar survival outcomes as those with pathological complete response (pCR, RCB-0). In whole cohort, for the RCB index and the Miller-Payne system, respectively, C-indexes for DFS were 0.73 and 0.64, for DSS were 0.74 and 0.64. The average RCB score was different among three subtypes (F=9.335, P<0.001).
The RCB index and the Miller-Payne system can stratify survival outcome of patients after NAC, and RCB had a superior prediction accuracy, especially for triple-negative breast cancer (TNBC). New cut-off value should be sought in order to improve prediction accuracy.
The RCB index and the Miller-Payne system can stratify survival outcome of patients after NAC, and RCB had a superior prediction accuracy, especially for triple-negative breast cancer (TNBC). New cut-off value should be sought in order to improve prediction accuracy.
The incidence and mortality of thyroid cancer vary based on race as well as gender. Both gender thyroid cancer patients give variable clinical characteristics, such as tumor size and distant metastasis. read more However, sex differences in the prognosis of thyroid cancer remain controversial. Therefore, the present study explored the relationship between gender and prognosis of patients with thyroid cancer for conducive personalized treatment.
A retrospective analysis was carried out on patients with pathologically proven thyroid cancer from the Surveillance, Epidemiology, and End Results (SEER) database. The gender disparities in the prognosis of different cohorts, derived by propensity score matching were investigated using Cox proportional hazards models and Kaplan-Meier curves.
Among the studied 41,270 female and 13,188 males with thyroid cancer, gender was an independent prognostic factor for overall (OS) and cancer-specific (CSS) survival (HR =1.632, 95% CI 1.499-1.777, P<0.001; HR =1.473, 95% CI 1.245-CSS. Other factors including race, age, income, histological type, surgery, T, N, M stage influenced OS of male and female thyroid cancer patients. Interestingly, race had no impact on CSS of thyroid cancer patients, whereas median income affected only the male patients CSS.
Our study demonstrated that male patients had a prognostic factor for poorer OS and CSS. Other factors including race, age, income, histological type, surgery, T, N, M stage influenced OS of male and female thyroid cancer patients. Interestingly, race had no impact on CSS of thyroid cancer patients, whereas median income affected only the male patients CSS.
Carbon nanoparticles (CNs) have been used intraoperatively in open thyroid surgery to facilitate central neck dissection and parathyroid protection. However, little attention was paid to the preoperative injection of CNs. Its safety and feasibility remain to be evaluated in bilateral axillo-breast approach robotic thyroidectomy (BABA RT).
In this retrospective cohort study, 114 papillary thyroid cancer patients (PTC) undergoing BABA RT were enrolled from March 2020 to March 2021. In the CNs group (n=64), 0.15 mL of CNs was injected into the thyroid lobules with malignant nodules the day before surgery. Medical records were reviewed and analyzed, including complications of CNs usage, surgical outcomes, central lymph node (CLN) retrieval, and parathyroid glands (PGs)-related parameters.
No significant differences were found between the CNs and the control groups in terms of general characteristics and surgical parameters. Complications of CNs were rare in the CNs group. The mean number of retrieved CLN was significantly higher in the CNs group than in the control group (9.48±4.88
5.40±2.67, P<0.001), as was the mean number of metastatic CLN (2.00±2.56
1.04±1.70, P=0.018). There were no differences in PGs preserved in situ, PGs autotransplantation, and postoperative PTH levels on the first day and first month (all P>0.05).
In patients with PTC undergoing BABA RT, preoperative application of CNs is a safe and feasible method to facilitate central neck dissection. However, the value of the preoperative application of CNs in robotic thyroidectomy needs to be further studied because it has no significant benefit for parathyroid protection.
In patients with PTC undergoing BABA RT, preoperative application of CNs is a safe and feasible method to facilitate central neck dissection. However, the value of the preoperative application of CNs in robotic thyroidectomy needs to be further studied because it has no significant benefit for parathyroid protection.
In breast cancer surgery, electrocautery (EC) is commonly used with the basic method of knot tying, and there are few reports of using other devices such as ultrasonic dissection device (UDD). This study was designed to compare the case of using EC with the basic method of knot tying and the case of using UDD in breast cancer surgery.
From April 2019 to March 2020, 376 patients who underwent breast cancer surgery at Pusan National University Hospital were enrolled. We compared operation time, complications, and blood loss volume between surgery with and without UDD.
We included 306 patients for the final analysis, 142 in the control group and 164 in the trial group. The operation time [minutes (min)] was significantly reduced in the trial group compared to the control group (111.2
95.5 min, P<0.001). In subgroup analysis, the operation time in the trial group was significantly reduced. There was no significant difference in intraoperative blood loss (P=0.999) and complications [seroma (P=0.965), hematoma (P=0.
