Hartleybrink5454

ment for examining the above questions. We here provided the first-ever overview of archaeal community structure and biogeography in mangroves located along an over-9,000-km coastline of southeastern China. We observed that archaeal diversity in low-latitude mangroves was higher than that in high-latitude mangroves. Furthermore, our data indicated that homogeneous selection strongly controlled the assembly of the overall and conditionally rare taxon communities in mangrove sediments, while the dominant taxon and always-rare taxon communities were mainly controlled by dispersal limitation.Aim To explore the expression profiles of long noncoding RNAs (lncRNAs) and identify novel lncRNAs as biomarkers for early diagnosis and therapy of hepatocellular carcinoma (HCC). Materials & methods Expression profiles of lncRNAs and mRNAs in five paired HCC and adjacent normal tissues were obtained by RNA sequencing. Eight lncRNAs, including two novel liver-specific lncRNAs (NONHSAT059247.2 and NONHSAT013897.2), were validated in another 74 pairs of HCC and adjacent normal tissues by quantitative reverse transcription PCR. Results The results of quantitative reverse transcription PCR showed that NONHSAT252133.1, NONHSAT112116.2 and NONHSAT242657.1 were significantly upregulated in HCC tissues, whereas NONHSAT169790.1, NONHSAT059247.2 and NONHSAT013897.2 were significantly downregulated. Two liver-specific lncRNAs demonstrated excellent diagnostic performance NONHSAT059247.2 (area under the curve = 0.941, 95% CI 0.902-0.979, p less then 0.0001), NONHSAT013897.2 (area under the curve = 0.944, 95% CI 0.906-0.983, p less then 0.0001). Conclusion The liver-specific lncRNAs NONHSAT059247.2 and NONHSAT013897.2, may provide new biomarkers for the future study on diagnosis, therapy, and mechanisms of HCC.

Many studies have investigated the devastating health effects of heat waves, but less is known about health risks related to cold spells, despite evidence that extreme cold may contribute to a larger proportion of deaths.

We aimed to systematically investigate the association between cold spells and mortality in Japan.

Daily data for weather conditions and 12 common causes of death during the 1972-2015 cold seasons (November-March) were obtained from 47 Japanese prefectures. Cold spells were defined as







≥





2





consecutive days with daily mean temperatures







≤





5





th





percentile for the cold season in each prefecture. Quasi-Poisson regression was combined with a distributed lag model to estimate prefecture-specific associations, and pooled associations at the national level were obtained through random-effects meta-analysis. The potential influence of cold spell characteristics (intensity, duration, and timing in season) on associats were relatively flat for all-cause mortality and other outcomes.

Our findings may have implications for establishing tailored public health strategies to prevent avoidable cold spell-related health consequences. https//doi.org/10.1289/EHP7109.

Our findings may have implications for establishing tailored public health strategies to prevent avoidable cold spell-related health consequences. https//doi.org/10.1289/EHP7109.Evidence shows that treatment by gynecologic oncologists (GOs) increases overall survival among women with ovarian cancer. However, specific strategies for institutions and community-based public health programs to promote treatment by GOs are lacking. To address this, we conducted a literature review to identify evidence-based and promising system- and environmental-change strategies for increasing treatment by GOs, in effort to ensure that all women with ovarian cancer receive the standard of care. We searched for English-language literature published from 2008 to 2018. We used PubMed, PubMed Central, OVID, and EBSCO for peer-reviewed literature and Google and Google Scholar for gray literature related to increasing receipt of care by GOs among ovarian cancer patients. Numerous suggested and proposed strategies that have potential to increase treatment by GOs were discussed in several articles. We grouped these approaches into five strategic categories increasing knowledge/awareness of role and importance of GOs, improving models of care, improving payment structures, improving/increasing insurance coverage for GO care, and expanding or enhancing the GO workforce. We identified several strategies with the potential for increasing GO care among ovarian cancer patients, although currently there is little evidence regarding their effectiveness across US populations. Public health programs and entities that measure delivery of quality health care may pilot the strategies in their populations. Certain strategies may work better in certain environments and a combination of strategies may be necessary for any one entity to increase GO ovarian cancer care. Findings, lessons learned, and recommendations from implementation projects would inform community and public health practice.Background This study focused on poor coping flexibility, which involves the perseveration of a failed coping strategy, as a moderator of the association between depression and suicidal risk; no study has previously examined the association between coping flexibility and suicidal risk. Aims This study examined whether individuals with lower coping flexibility would have a stronger suicidal risk when experiencing depression above a certain level. Method Participants, who were 682 college students, answered questionnaires regarding coping flexibility, depressive symptoms, and suicidal risk. Results Hierarchical multiple regression analyses showed that in individuals with greater depressive symptoms, lower coping flexibility was associated with higher suicidal risk, but this was not the case in individuals without depressive symptoms. Our hypothesis was supported. Limitations Our findings cannot indicate the causal direction of the association between coping flexibility and depressive symptoms and suicidal risk. Conclusion Our findings may be useful in understanding the association between depression and suicidal risk through coping flexibility and contribute to reductions in suicidal risk, as coping flexibility can be improved through training.Metal-organic frameworks (MOFs) have been proposed as emerging fillers for composite polymer electrolytes (CPEs). However, MOF particles are usually served as passive fillers that yield limited ionic conductivity improvement. Building continuous MOF reinforcements and exploiting their active roles remain challenging. Here we demonstrate the feasibility of engineering fast Li+ conduction within MOF on molecule conception. Two-dimensional Cu(BDC) MOF is selected as an active filler due to its sufficient accessible open metal sites for perchlorate anion anchoring to release free Li+, verified by theoretical calculations and measurements. A novel Cu(BDC)-scaffold-reinforced CPE is developed via in situ growth of MOF, which provides fast Li+ channels inside MOF and continuous Li+ paths along the MOF/polymer interface for high Li+ conductivity (ambient 0.24 mS cm-1) and enables high mechanical strength. Stable cycling is achieved in solid-state Li-NCM811 full cell using the MOF-reinforced CPE. This molecule-basis Li+ conduction strategy brings new ideas for designing advanced CPEs.The first total synthesis of thuggacin cmc-A and the determination of the absolute structure are described. The thuggacin family of antibiotics is of great interest due to the antibiotic activity against Mycobacterium tuberculosis. Based on the assumption that seven stereogenic centers in thuggacin cmc-A would share the same stereochemistry as thuggacin-A, all stereogenic centers of thuggacin cmc-A were strictly constructed in a stereocontrolled manner. The total synthesis allowed its stereostructure to be fully confirmed.Retigeranic acid A is a uniquely structured pentacyclic sesterterpene bearing eight stereogenic centers. We report a concise route to the core structure of (-)-retigeranic acid A. The stereochemistry of its six chiral centers and three quaternary carbon centers was well-controlled. This route features two intramolecular Pauson-Khand reactions (IMPKRs) the first forged the D and E rings to deliver the triquinane subunit, and the second constructed the A and B rings and diastereoselectively installed the quaternary C6a center.DNA origami structures represent an exciting class of materials for use in a wide range of biotechnological applications. This study reports the design, production, and characterization of a DNA origami "zipper" structure, which contains nine pH-responsive DNA locks. Each lock consists of two parts that are attached to the zipper's opposite arms a DNA hairpin and a single-stranded DNA that are able to form a DNA triplex through Hoogsteen base pairing. The sequences of the locks were selected in a way that the zipper adopted a closed configuration at pH 6.5 and an open state at pH 8.0 (transition pKa 7.6). By adding thiol groups, it was possible to immobilize the zipper structure onto gold surfaces. The immobilization process was characterized electrochemically to confirm successful adsorption of the zipper. The open and closed states were then probed using differential pulse voltammetry and electrochemical impedance spectroscopy with solution-based redox agents. It was found that after immobilization, the open or closed state of the zipper in different pH regimes could be determined by electrochemical interrogation. These findings pave the way for development of DNA origami-based pH monitoring and other pH-responsive sensing and release strategies for zipper-functionalized gold surfaces.The development of photoluminescent (PL) systems, displaying multiple stimuli-responsive emission color tuning, has been the pressing priority in the recent times due to their huge role in contemporary lighting and anticounterfeiting technologies. Acknowledging this importance, we present a simple and eco-friendly PL system showing emission color tuning in response to different stimuli, that is, the composition of the system, pH, excitation wavelength, and the temperature with the plus point of getting significantly pure white light emission (WLE). The novel system is fabricated from the aqueous mixture of three organic fluorophores, umbelliferone (UMB), fluorescein (FLU), and Rhodamine-B (RB). By varying the fluorophore composition in the mixture at pH 12, nearly pure WLE with a Commission Internationale d'Eclairage (CIE) 1931 profile of (0.33, 0.33) was obtained at the excitation wavelength of 365 nm, the sustainability of which was ensured by employing the micellar self-assemblies of tetradecyltrimethylammonium bromide (TTAB) molecules. Similar WLE was obtained under mildly acidic conditions (pH 6) but at the excitation wavelength of 330 nm. By proper tuning of pH and the wavelengths of the system to use it as a fluorescent ink, we found a remarkable and highly applicable phenomenon observed for the first time, that is, triple-mode orthogonal emission color tuning with white light ON/OFF switching. We validate the vital applicability of this phenomenon in protecting the authenticity of the document with its hard-to-counterfeit property. The applicability of this phenomenon is also explored by synthesizing PVA-based fluorescent films from the tri-fluorophore mixture. selleck chemicals llc Moreover, the emission color of the PL system was explored lucidly for its temperature dependence owing to the thermal responsiveness of RB emission, where the PL system proves to be a full-color RGB system.