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This interpretative phenomenological study explored play experiences between mothers who had completed, or were receiving treatment for, breast cancer and their young children and disease-related factors influencing those experiences. Six Puerto Rican mothers who had young children at the time of their primary treatment were interviewed. Interviews were recorded, transcribed, and analyzed through constant comparative method. Two themes emerged (a) "changes and challenges," which contextualized disease-related factors affecting the maternal role; and (b) "play and relationships with children" described play moments and how treatment affected these. Participants emphasized the benefits of playing and relating with their children while in treatment. Play as a co-occupation and an effective means to connect mothers with their children must be considered in the practice of occupational therapy. Future studies with more diverse samples of mothers at different stages of the disease are warranted to expand this exploratory work.Malaria-causing parasites rely on an actin-myosin-based motor for the invasion of different host cells and tissue traversal in mosquitoes and vertebrates. The unusual myosin A of Plasmodium spp. has a unique N-terminal extension, which is important for red blood cell invasion by P. falciparum merozoites in vitro and harbors a phosphorylation site at serine 19. Here, using the rodent-infecting P. berghei we show that phosphorylation of serine 19 increases ookinete but not sporozoite motility and is essential for efficient transmission of Plasmodium by mosquitoes as S19A mutants show defects in mosquito salivary gland entry. S19A along with E6R mutations slow ookinetes and salivary gland sporozoites in both 2D and 3D environments. In contrast to data from purified proteins, both E6R and S19D mutations lower force generation by sporozoites. Our data show that the phosphorylation cycle of S19 influences parasite migration and force generation and is critical for optimal migration of parasites during transmission from and to the mosquito.Speech-language pathologists have embraced many aspects of technology in their practice, from telehealth to tablet device applications (apps) that support intervention practice. In this article, we consider the design, development, and implementation of technology. We discuss how some processes of technology development in Speech-language pathology (SLP) tend to follow research pathways which centre clinicians and researchers as designers of the intervention. This approach side-lines user involvement. We propose that a Participatory Design framework is a suitable way to reconceptualise design and development of these technological innovations in a client-centred way. Further, we explore how Participatory Design approaches utilise methods from and have much in common with qualitative research. We explore this overlap and propose that technology design teams take up the challenge of innovation in technology by engaging in a participatory rather than clinician-driven process for future technology design. Implications for both research and clinical practice are explored.The front cover artwork is provided by Dr. Ping Nie and Prof. Limin Chang at Jilin Normal University. The image shows one-dimensional silicon-nitrogen-doped carbon nanotube composite fabricated through a dealloying process. The nanotube engineered silicon coupled with conductive carbon coating synergistically boosts the electrochemical performance. Read the full text of the Research Article at 10.1002/cphc.202100832.The present study explored the predictive value of culprit high-risk plaque (HRP) detected by optical coherence tomography (OCT) for predicting major adverse cardiovascular events (MACEs) in patients with ST-segment elevation myocardial infarction (STEMI). HRP was defined as the simultaneous presence of four criteria minimum lumen area 180°, and presence of macrophages. Patients (n = 274) were divided into non-HRP group (n = 206) and HRP group (n = 68). MACEs were defined as a composite of all-cause death, myocardial infarction, stroke, and revascularization. During a mean follow-up of 2.2 years, 47 (17.5%) MACEs were observed 28 (13.6%) in the non-HRP group and 19 (27.9%) in the HRP group (log-rank P = .005). Patients with HRP were 2.05 times more likely to suffer from a MACE than those without HRP (hazards ratio 2.05, 95% confidence interval 1.04-4.02, P = .038); MACE risk was comparable between plaque rupture and plaque erosion. In conclusion, HRP was present in 24.8% of STEMI patients and associated with higher cardiovascular risk independent of plaque rupture, suggesting that HRP detected by OCT may help identify patients at high risk of future cardiac events.

To assess if cancer-specific survival (CSS) following curative intent treatment (CIT) for muscle-invasive bladder cancer (MIBC) differs between patients presenting with MIBC (primary) and patients presenting with non-muscle-invasive bladder cancer who progress to MIBC (secondary).

This study uses data from the Cancer Registry of Norway on patients initially diagnosed with bladder cancer in 2008-2012 and treated with radical cystectomy (RC) or radiotherapy (RT). To ensure a clinically relevant population, we selected patients with a pre-treatment histology confirming muscle-invasion. Survival models were applied to evaluate differences in observed and adjusted CSS by type of MIBC and stratified by type of CIT. Adjustment was made for age group, sex, previous cancer, diagnostic hospital's academic status and geographical region, and type of CIT.

We identified 650 eligible patients 589 (91%) primary MIBC and 61 (9%) secondary MIBC. A total of 556 (86%) patients underwent RC and 94 (14%) RT. The 5-year CSS lecular and genetic characteristics in addition to detailed clinicopathologic information.To investigate whether flash-free adhesive ceramic brackets (FFA) have a better clinical performance than conventional adhesive ceramic brackets (CVA) in patients undergoing multi-bracket orthodontic treatment. PubMed, CENTRAL, Web of Science, Scopus, Embase, CNKI and Grey-literature were searched without restrictions up to January 2022. Both randomized controlled trials (RCTs) and controlled clinical trials (CCTs) were included. Risk of bias assessment was performed using the RoB 2.0 and ROBINS-I cochrane risk of bias tools. Eight articles, for seven studies, were included in this systematic review, and four split-mouth trials (SMT) were included in the meta-analysis. A random-effects meta-analysis found a statistically significant faster bonding time with FFA (mean difference [MD] = -93.85 seconds/quadrant, P = .002, 2 SMT), and no statistically significant difference regarding bracket failure rate at 6 months (risk ratio [RR] = 1.05; P = .93, 3 SMT), adhesive removal time (MD = -18.26 seconds/quadrant, P = .50, 2 SMT), and amount of remnant adhesive (MD = -0.13/bracket, P = .72, 2 SMT) between FFA and CVA. No difference (P > .05, 3 SMT) was found in enamel demineralization and periodontal measurements. CVA showed a statistically significant higher debonding pain score (P = .004, 1 SMT). Both flash-free and conventional adhesive ceramic brackets had a similar clinical performance, except for the faster bonding with FFA. Further, well-designed clinical trials are still required.Precise control over interparticle interactions is essential to retain the functions of individual components in a self-assembled superstructure. Here, we report the design of a multifunctional bioplasmonic network via an electrostatically directed self-assembly process involving adenosine 5'-triphosphate (ATP). The present study unveils the ability of ATP to undergo a long-range self-assembly in the presence of cations and gold nanoparticles (AuNP). Modelling and NMR studies gave a qualitative insight into the major interactions driving the bioplasmonic network formation. ATP-Ca2+ coordination helps in regulating the electrostatic interaction, which is crucial in transforming an uncontrolled precipitation into a kinetically controlled aggregation process. Remarkably, ATP and AuNP retained their inherent properties in the multifunctional bioplasmonic network. The generality of electrostatically directed self-assembly process was extended to different nucleotide-nanoparticle systems.Bibliography Dr Sanne Peters is an Associate Professor at The George Institute for Global Health and a Senior Lecturer at Imperial College London. She is also Associate Professor at the University Medical Center Utrecht. After completing her MSc in Epidemiology in 2009, she obtained a PhD in Epidemiology from Utrecht University in 2012. Her PhD focused on subclinical imaging measures of atherosclerosis as a means to identify people at high-risk for future cardiovascular disease. As part of her PhD training, she spent 6 months at The George Institute in Sydney. This is where she started her research on sex differences in cardiovascular disease. In 2013, she was awarded a postdoctoral fellowship, which enabled her to continue her work on sex differences at the University of Cambridge. In 2014, she was offered a position at the George Institute offices at the University of Oxford (now in collaboration with Imperial College London). In 2018, she relocated back to the Netherlands and was also appointed as Associate Professor in Utrecht.

The aim of this study was to gain insight into factors affecting career adaptability of newly graduated nurses and ways to improve them.

Newly graduated nurses face an important transition from student to professional. Unfortunately, the nurse turnover rate is high due to maladaptation. Factors influencing career adaptability and improvement methods have not been clearly addressed.

Using a descriptive qualitative study with thematic analysis, 15 newly graduated nurses from a tertiary obstetrics and gynaecology teaching hospital in China were interviewed.

Six themes affecting career adaptability were found personality, self-confidence, occupational care focus, work-related stress, basic professional competency and gap between reality and expectations. Four themes improving career adaptability were identified strong social support, self-adjustment, self-development and career preparation. Eight subthemes were also identified.

Individual, family and work factors were among those affecting career adaptability among newly graduated nurses. Newly graduated nurses would improve their career adaptability through self-adjustment and social support. click here Helping them to promote these factors and measures is conducive to improving their career adaptability and reducing staff turnover.

Nurse managers should be aware of the key factors affecting career adaptability among newly graduated nurses and design targeted improvement programmes.

Nurse managers should be aware of the key factors affecting career adaptability among newly graduated nurses and design targeted improvement programmes.

Wellness Recovery Action Planning (WRAP

) is a recovery-oriented program designed for people with mental illness to improve well-being and self-manage symptoms.

This randomized controlled trial investigates the effectiveness of brief Wellness Recovery Action Planning (WRAP

) as a mental health self-management tool for adults without formal clinical diagnoses in Hong Kong.

182 adults were randomly assigned to WRAP

or waitlist control condition to investigate whether WRAP

can promote mental well-being and reduce psychological distress for community adults with no known diagnosable mental disorders.

Significant improvements were found in depressive (





= .11) and anxiety symptoms (





= .06), empowerment (





= .09), and personal recovery (





= .11) among WRAP

participants compared with waitlist control participants. Moreover, changes in anxiety symptoms, hope, empowerment, and reliance on others were found to sustain at 3-month follow-up.

Brief WRAP

is an effective self-management tool in enhancing mental health and alleviating psychological distress for millennials living in the community.