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00 ± 4.53) after minimally invasive surgery (P < 0.05). (3) The change in the WAI questionnaire score after minimally invasive surgery was influenced by the occupational category and the change in ESS.
Minimally invasive surgical treatment shows significant benefit in improving the sleep quality and working ability of patients with OSAHS.
Minimally invasive surgical treatment shows significant benefit in improving the sleep quality and working ability of patients with OSAHS.
To estimate the severity of flow limitation in patients withOSA, the number of breaths with flattened inspiratory flow curves should be identified. Attempts to do a quantitative analysis of the flattening degree for all breaths in a nighttime recording havefailed up to now.
SOMNOmedics (Randersacker, Germany) developed an automated flattening analysis parameter calledthe obstructive coefficient (OC). Polysomnographic measurement including esophageal manometry was done in 25 subjects (10 healthy, 9patients with mild OSA, and 6 withsevere OSA). For each breath, the data couple of OC and esophageal pressure (EP) was used for analysis.
Data couples of OC and EP were recorded for 104,608 breaths. Airway patency histogram profiles for each study group showed no remarkable differences between each other. Increase in EP with increasing RDI was identified as the only marker of OSA severity. A strong shift was observed in N3 breaths from maximum OC/lowest EP values in healthy subjects to low OC values in association with maximum EP values in OSA.
The OC enables quantification of all breaths of a nighttime recording according to their degree of flattening. The relation of strong limited to less strong limited breaths is the same across the three study groups. The analysis of the corresponding EP to a given OC value for each study group identified the EP that is necessary to cause a given flow as the only parameter that discriminates degrees of severity of OSA. The trial registration number is DRKS00018095 from 2019 to 10-09.
The OC enables quantification of all breaths of a nighttime recording according to their degree of flattening. The relation of strong limited to less strong limited breaths is the same across the three study groups. The analysis of the corresponding EP to a given OC value for each study group identified the EP that is necessary to cause a given flow as the only parameter that discriminates degrees of severity of OSA. The trial registration number is DRKS00018095 from 2019 to 10-09.
The International Classification of Sleep Disorders (ICSD)-3 was developed to aid in the identification of these disorders. The core criterion A (ICSD-3A) to identify obstructive sleep apnea (OSA) requires the presentence of specific signs and symptoms. This study explores the predictive ability of the ICSD-3A for OSA as compared with objective measures of respiratory event index (REI).
A total of 291 participants who completed a home sleep apnea test (HSAT) during the screening evaluation of the Assessing Daily Activity Patterns through occupational Transitions (ADAPT) study were included.
Participants were classified as having mild OSA (REI ≥ 5 and < 15), moderate (≥ 15 to < 30), or severe OSA (> 30). Predictive parameters identifying participants as having OSA by the ICSD-3A criteria were assessed using REI classifications as the reference standard and further compared with a subsample using the STOP-Bang questionnaire.
The ICSD-3A had a sensitivity of 19.2% for identifying participants as having moderate to severe OSA and specificity of 84.4%. The ICSD-3A had a receiver operating characteristics (ROC) = 0.53. On the subsample of participants, the STOP-Bang questionnaire's ROC is 0.61. Results were similar when examining the classification of participants with mild compared with no OSA.
In this population, the ability of the ICSD-3A in detecting moderate to severe OSA as well as mild OSA was low. The ROC for the ICSD-3 did not differ significantly from the STOP-Bang questionnaire's ROC in this research population.
In this population, the ability of the ICSD-3A in detecting moderate to severe OSA as well as mild OSA was low. 1-NM-PP1 molecular weight The ROC for the ICSD-3 did not differ significantly from the STOP-Bang questionnaire's ROC in this research population.Although chemotherapy is a key cancer treatment, many chemotherapeutic drugs produce chronic neuropathic pain, called chemotherapy-induced neuropathic pain (CINP), which is a dose-limiting adverse effect. To date, there is no medicine that prevents CINP in cancer patients and survivors. We determined whether blockers of the canonical Wnt signaling pathway prevent CINP. Neuropathic pain was induced by intraperitoneal injection of paclitaxel (PAC) on four alternate days in male Sprague-Dawley rats or male Axin2-LacZ knock-in mice. XAV-939, LGK-974, and iCRT14, Wnt/β-catenin blockers, were administered intraperitoneally as a single or multiple doses before or after injury. Mechanical allodynia, phosphoproteome profiling, Wnt ligands, and inflammatory mediators were measured by von Frey filament, phosphoproteomics, reverse transcription-polymerase chain reaction, and Western blot analysis. Localization of β-catenin was determined by immunohistochemical analysis in the dorsal root ganglia (DRGs) in rats and human. Our phosphoproteome profiling of CINP rats revealed significant phosphorylation changes in Wnt signaling components. Importantly, repeated systemic injections of XAV-939 or LGK-974 prevented the development of CINP in rats. In addition, XAV-939, LGK-974, and iCRT14 ameliorated CINP. PAC increased Wnt3a and Wnt10a, activated β-catenin in DRG, and increased monocyte chemoattractant protein-1 and interleukin-1β in DRG. PAC also upregulated rAxin2 in mice. Furthermore, β-catenin was expressed in neurons, including calcitonin gene-related protein-expressing neurons and satellite cells in rat and human DRG. In conclusion, chemotherapy increases Wnt3a, Wnt10a, and β-catenin in DRG and their pharmacological blockers prevent and ameliorate CINP, suggesting a target for the prevention and treatment of CINP.
