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The results demonstrated that the IL-10 expression was markedly increased after HI and IL-10 were colocalized with neurons and astrocytes which were badly injured by HI insult. In addition, Bcl-2 and ERp29 were remarkably decreased following IL-10 mRNA interference compared with the NC group. Our findings revealed that IL-10 exerted its antiapoptotic and neuroprotective effects by regulating the expression of Bcl-2 and ERp29, indicating that IL-10 may be a promising molecule target for HIE treatment.N-trans-Feruloyloctopamine (FO), a natural compound, was reported in our previous study to inhibit a tumor cell malignant phenotype by AKT- and EMT-related signals and might be used as a promising drug for HCC treatment. However, the specific targets and detailed mechanisms still need to be clarified. Screening with RNA-Seq in Huh7 cells treated with FO revealed that 317 genes were modulated, of which 188 genes were upregulated and 129 genes were downregulated. Real-time cell analyzer and flow cytometry data reveal that tumor cell proliferation and apoptosis were impacted by FO. DAVID bioinformatic data showed that most of the biological process GO terms are related to proliferation and apoptosis. KEGG enrichment analysis showed that FO mainly regulates PI3K-AKT- and apoptosis-related signals, in which BBC3, DDIT3, NOXA, and CDKN1A on the surface serve as the novel targets of FO inducing HCC cell apoptosis. The result implied that FO might exacerbate HCC cell apoptosis by regulating BBC3, DDIT3, CDKN1A, and NOXA signals. The obstacle effect of FO can provide new targets and new credibility for the treatment of liver cancer.Environmental noise control is necessary for human health and auditory comfort conditions. In this respect, it is required that industrial noise should be kept under control and healthy living spaces should be obtained in residential areas. This paper aims to explain industrial noise control at urban and building scales. In this study, the strategic noise mapping process related to industrial activities in a line with the Environmental Noise Directive (END) was clarified. Besides this, what type of factors are effective in the industrial noise mapping process were defined, and important basic parameters, which are essential in the industrial noise mapping, were detailed. The preparation of the industrial noise mapping process was explained in detail. It was mentioned that the regions exposed to excessive noise should be defined according to the strategic noise map and improvement plans should be performed. Improvement methods that reduce excessive noise in living spaces are clarified and it was explained how the improvement of environmental quality can be acquired. In this regard, this paper gives information on industrial noise mapping and industrial noise control at the urban scale.

Domestic violence is a common health problem that often affects women's mental health. Although domestic violence may not be reported during quarantine, it may increase due to increased restrictions. Therefore, the goal of the present study was to develop and validate the Domestic Violence during Quarantine Scale (DVQS) on a sample from Iran.

Two hundred and three Iranians participated in this study and completed online questionnaires. This cross-sectional and methodological study consisted of two phases. In the first phase, item pool generation and questionnaire design was carried out through literature review. In the second phase, psychometric properties were assessed via an exploratory factors analysis (EFA). Internal consistency was examined by Cronbach's alpha coefficient and McDonalds' Omega.

In the EFA, three factors, including humiliation (seven items), threatening (six items), and restriction (four items) were extracted that together explained 64.4% of the variance of domestic violence during quarantine. Using Cronbach's alpha coefficient, the internal consistency of humiliation, threatening, and restriction was found to be 0.90, 0.896, and 0.76 respectively, and an alpha of 0.927 was found for the total scale. In addition, using McDonalds' Omega, internal consistencies of 0.82, 0.84, and 0.78 were found for the three factors respectively.

The DVQS has good validity and reliability; therefore, it can be used in future studies.

The DVQS has good validity and reliability; therefore, it can be used in future studies.Aim In 2017, the Institute for Quality Assurance and Transparency in Healthcare (IQTIG) introduced a quality assurance system for the surveillance of surgical site infections (SSI) on behalf the Federal Joint Committee. The establishment of the new system was made in parallel to existing methods, such as the "Krankenhaus-Infektions-Surveillance-System" (KISS). The aim of this work was to perform a comparative analysis. Methods All 2,233 cases at the University Medical Center Goettingen requiring an assessment of the presence of SSI as part of the IQTIG procedure in 2018 and 2019 were evaluated retrospectively according to the KISS protocol. Results In total, 2,050 patients were included in the comparative evaluation. Overall, 1,779 (79.7%) had a surgical anamnesis (surgery during the stay or in the past), and 1,716 (83.7%) showed identical results for both surveillance strategies. Kinase Inhibitor Library chemical structure Different results were found for 334 patients (16.3%), with 160 of these (7.8%) positive for SSI according to IQTIG and 174 (8.5%) positive for KISS. Risk factors were identified for a discordant assessment between the methods. Conclusion The congruence of the two strategies was consistently high over the study period. There is evidence that the efficiency of the documentation algorithm can be increased without the loss of documentation of SSI, while preserving the precision of the documentation through training.Background The cytotoxic effects of COVID-19 raise the question of a possible relation between COVID-19 infection and new-onset type 1 diabetes. We report the case of an eight-year-old boy with new-onset type 1 diabetes and an asymptomatic COVID-19 infection. Case presentation The eight-year-old boy was hospitalized on December 18th, 2020 due to increased polyuria during the preceding 1 week. Type 1 diabetes was diagnosed with autoantibodies against glutamic acid decarboxylase, tyrosine phosphatase and insulin. The Hba1c value was 11.6%. Upon admission, the PCR test for COVID-19 was positive, the duration of the infection was not clear due to the asymptomatic course, and antibodies were initially negative. Significantly elevated antibodies against COVID-19 were detected 15 days later. Conclusion The laboratory findings led us to the hypothesis that the boy already had an increased risk of developing autoimmune diseases (HLA DR3-DQB1*0201 and DR4-DQB1*0302 positive). The Hba1c value allows speculation that the diabetes manifestation was already "on the way" and that a relatively recent COVID-19 infection could have accelerated the process.