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Although at present depression is one of the most disabling disorders in our social environment, the understanding of its pathogenesis and the resources for its treatment are still unsatisfactory. The importance of brain asymmetry in the pathogenesis of disorders in brain function, including mood disorders such as depression, is a highly unexplored, sometimes underrated, and even ignored topic. It is important to note that the basal and pathological functional lateralization must have an underlying neurochemical substrate. It is also necessary to indicate that the brain asymmetry extends to a neurovisceral integration whose behavior may also be lateralized. One of the most studied axis from the functional point of view is the brain-heart connection, in whose operation there are observations that suggest an asymmetric behavior in basal conditions that is modified by central and peripheral changes, as well as by pharmacological treatments. There are evidences that connect cardiovascular function, neurochemical asymmetries, and depression. A deep understanding of the bilateral behavior of the brain following pathophysiological changes in blood pressure as well as pharmacologically induced, can provide us with therapeutic suggestions for the treatment of depression. In this article, we analyze remarkable results of some representative selected contributions, with which we discuss our proposal on the relationship between hypertension, depression and neurochemical asymmetry.Epidemic spread on networks is one of the most studied dynamics in network science and has important implications in real epidemic scenarios. Nonetheless, the dynamics of real epidemics and how it is affected by the underline structure of the infection channels are still not fully understood. Here we apply the susceptible-infected-recovered model and study analytically and numerically the epidemic spread on a recently developed spatial modular model imitating the structure of cities in a country. The model assumes that inside a city the infection channels connect many different locations, while the infection channels between cities are less and usually directly connect only a few nearest neighbor cities in a two-dimensional plane. We find that the model experience two epidemic transitions. The first lower threshold represents a local epidemic spread within a city but not to the entire country and the second higher threshold represents a global epidemic in the entire country. Based on our analytical solution we proposed several control strategies and how to optimize them. We also show that while control strategies can successfully control the disease, early actions are essentials to prevent the disease global spread.To date, no effective preventive or curative medical interventions exist against COVID-19, caused by Severe Acute Respiratory Syndrome corona virus 2 (SARS CoV-2). The available interventions are only supportive and palliative in nature. Popular among the emerging explanations for the mortality from COVID-19 is "cytokine storm", attributed to the body's aggressive immune response to this novel pathogen. In less than a year the disease has spread to almost all countries, though the mortality rates have varied significantly from country to country based on factors such as the demographical mix of the population, prevalence of comorbidities, as well as prior exposure to viruses from the corona family. This review examines the current literature on mortality rates across the globe, explores the possible reasons, thereby decoding variations. COVID-19 researchers have noted unique characteristics in the structural and host-pathogen interaction and identified several possible target proteins and sites that could exhibit control over the entry of SARS CoV-2 into the host, which this paper reviews in detail. Identification of new targets, both in the virus and the host, may accelerate the search for effective vaccines and curative drugs against COVID-19. Further, the ontological approach of this review is likely to provide insights for researchers to anticipate and be ready for future mutant viruses that may emerge in future.On April 20th, 2020, 2,403,410 cases of corona Virus were confirmed globally. This date matches the end of the first strict lockdown in Morocco.. The number of Morocco confirmed cases attended 2990 and 143 deaths were recorded. Due to the pandemic, all avoidable activities in the country were prohibited since the kingdom announced the general lockdown on March 20th, 2020. This study aims at comparing the air quality status, before the pandemic and during the confinement. It was performed in Casablanca and Marrakech from Morocco. The main objective is to show whether COVID-19 compelled lockdown may have saved lives by restraining air pollution than by preventing infection. We used the difference-in-difference and the Theil and Sen non-parametric approaches for univariate time series. We defined the before quarantine period as between February 16th and March 19th and the during quarantine as between the March 20th and April 20th. We assessed changes in air quality during vs. Gefitinib before the quarantine period in 2020 and compared these with corresponding changes in the same lunar calendar periods in 2016-2019. Then we calculated the avoided cause-specific mortality attributable to the decreases in NO2 and PM2.5 based on the concentration-response functions from previous studies. We found that NO2 dropped by -12 μg/m3 in Casablanca and - 7 μg/m3 in Marrakech. PM2·5 dropped by -18 μg/m3 in Casablanca and - 14 μg/m3 in Marrakech. CO dropped by -0.04 mg/m3 in Casablanca and - 0.12 mg/m3 in Marrakech. This air pollution reduction had created human health benefits. It reduced mortality, and saved lives mainly from cardiovascular diseases. Further investigation may be undertaken to explore the reduction in the concentrations of industry-related pollutants.COVID-19 procedural restrictions and concerns from both practitioners and patients have led to a decrease in cosmetic procedures performed. Reduced clinic space, the necessity of distancing between people, and patient preference for a smaller care team may restrict trainees from observing, assisting with, or performing procedures. Thus, trainees may be limited in their ability to learn, practice, and meet the required number of cases to achieve competence, subsequently necessitating a sustained demand for alternative methods of learning. In this review, we examine the efforts made thus far by both dermatologists and dermatology organizations to meet the educational procedural needs of trainees and compensate for limitations during the pandemic and highlight areas in which innovation may still be needed.