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A series of configuration-controlled Fe(ii)-Ir(iii) heteronuclear metal complexes, including ferrocene and half-sandwich like iridium(iii) complex units, have been designed and prepared. These complexes show better anticancer activity than cisplatin under the same conditions, especially cis-configurational ones. click here Laser confocal microscopy analysis confirms that the complexes follow a non-energy-dependent cellular uptake mechanism, accumulate in lysosomes (pearson co-localization coefficient ∼0.7), lead to lysosomal damage, and eventually induce apoptosis. These complexes can reduce the mitochondrial membrane potential, disturb the cell circle, catalyze the oxidation of nicotinamide-adenine dinucleotide (NADH) and increase the levels of intracellular reactive oxygen species (ROS), following an anticancer mechanism of oxidation. In addition, the complexes could bind to serum protein, and transport through it. Above all, the Fe(ii)-Ir(iii) heteronuclear metal complexes hold promise as potential anticancer agents for further study.A decarboxylative, desulfonylative Smiles rearrangement is presented that employs activated-ester/energy transfer catalysis to decarboxylate β-amino acid derived starting materials at room-temperature under visible light irradiation. The radical Smiles rearrangement gives a range of biologically active arylethylamine products highly relevant to the pharmaceutical industry, chemical biology and materials science. The reaction is then applied to the synthesis of a chiral unnatural amino acid, 2-thienylalanine, used in the treatment of phenylketonuria. We also show how the reaction can proceed under metal-free and catalyst-free conditions.Different from the traditional role of a Brønsted base, amines/imines have been widely employed during the past few decades as a Lewis base to activate electrophilic allene, olefin, and carbonyl compounds. Understanding the detailed mechanisms and the origin of chemo- and stereo-selectivities for these types of reactions should be very important and highly desirable. In this minireview, the recent advances and methods for analysis of the origin of the selectivities of novel Lewis base amine/imine-mediated reactions are systematically summarized and reviewed from a theoretical viewpoint. This information provides valuable insights for understanding the general action modes of Lewis base amine/imine catalysts and rational design of more efficient organocatalytic reactions with high stereoselectivity and special chemoselectivity.Of all cyanobacteria, Microcystis aeruginosa is the most commonly found species in bloom episodes all over the world. This species is known to produce cyanopeptides with hepatotoxic effects, namely microcystins (MCs). In this regard, Advanced Oxidation Processes (AOPs) have been widely studied for cyanotoxin degradation, but very few studies focused on cyanobacteria inactivation combined with toxin removal. To our knowledge, this is the first report of the photo-Fenton process application focusing on M. aeruginosa inactivation and microcystin-LR (MC-LR) degradation. This research work aimed to evaluate the photo-Fenton process under three different conditions with regard to Fe2+/H2O2 ratios (0.6/10, 5/50, and 20/100 mg L-1) at the initial near-neutral pH. Process efficiency was measured by immediate cell density reduction, growth inhibition, effect on MC-LR concentrations, and scanning electron microscopy (SEM) to analyze any alterations in cell morphology. Growth inhibition test (GIT) results pointed to cell inactivation under all conditions tested, and MC-LR concentrations were reduced below WHO's maximum limit at medium and higher concentrations of reagents. The possible mechanisms of cell inactivation by oxidative species are discussed.This systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to summarize the effect of almond intake on anthropometric indices in adult subjects. We searched PubMed, Scopus, ISI Web of Science, Cochrane Library, and Google Scholar databases until January 2020 to identify relevant RCTs. Data were reported as weighted mean differences (WMDs) and standard deviations (SDs) to show the magnitude of effects of almond on body weight (BW), body mass index (BMI), waist circumference (WC), fat mass (FM), and fat-free mass (FFM). Out of 2983 reports, 28 RCTs (37 arms) were eligible for including in our meta-analysis. The pooled results, obtained using a random-effects model, showed that almond intake significantly decreased BW (WMD -0.38 kg, 95% CI -0.65, -0.10, p = 0.007, I2 = 30.5%) and FM (WMD -0.58 kg, 95% CI -0.87, -0.28, p less then 0.001, I2 = 4.9%). However, we found no significant effect of almond administration on BMI (WMD -0.30 kg m-2, 95% CI -0.67, 0.06, p = 0.101, I2 = 62.6%), WC (WMD -0.60 cm, 95% CI -1.28, 0.06, p = 0.078, I2 = 0.0%), and FFM (WMD 0.23 kg, 95% CI -0.04, 0.50, p = 0.097, I2 = 49.5%). Overall, the current meta-analysis demonstrated that resveratrol almond intake significantly reduced weight and FM, but did not affect BMI, WC, and FFM. Further studies are still required to confirm our results.The efficiency of soft particles to stabilize emulsions is examined by measuring their desorption free energy, i.e., the mechanical work required to detach the particle from a fluid interface. Here, we consider rubber-like elastic as well as microgel particles, using coarse-grained molecular dynamics simulations. The energy of desorption is computed for two and three-dimensional configurations by means of the mean thermodynamic integration method. It is shown that the softness affects the particle-interface binding in two opposing directions as compared to rigid particles. On the one hand, a soft particle spreads at the interface and thereby removes a larger unfavorable liquid-liquid contact area compared to rigid particles. On the other hand, softness provides the particle with an additional degree of freedom to get reshaped instead of deforming the interface, resulting in a smaller restoring force during the detachment. It is shown that the first effect prevails so that a soft spherical particle attaches to the fluid interface more strongly than rigid spheres.