Finleyalbright0273

An efficient, green strategy for synthesis of 1,4-disubstituted-1,2,3-triazole has been developed using 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) acetate ionic liquid (200 μL) under a solvent- and external base-free condition. This protocol is further applied for the synthesis of novel amino acid containing 1,2,3-triazole molecules, which were then evaluated for potential antitubercular and antibacterial activities. Cytotoxicity assay of the compounds was also performed. In silico analysis of the promising compounds selected through experimental analysis was thereafter performed for visualizing molecular interactions and predicting binding affinities between our synthesized molecules, which exhibited good activity in experimental studies and the DprE1 target protein of Mycobacterium tuberculosis. Durg-likeness studies also show potential of the synthesized molecules as drug candidates.Low salinity water flooding is a low-cost enhanced oil recovery (EOR) technology. The mechanism of EOR in a sandstone reservoir is still controversial, and there are many influencing factors. In this study, the effects of salinity (2000, 4000, 8000, and 100,000 ppm), pH (5.5 acidic, 7.0 neutral, and 8.0 alkaline), cation type (Na+ and Ca2+), and clay content (A rock 6.04%, B rock 11.94%) on zeta potential and recovery related to clay swelling were studied. The results showed that the absolute value of zeta potential increased with the decrease of salinity, cation changes from divalent to monovalent, and an increase of the pH value or clay content. The results of the SEM test before and after displacement and the continuous increase of displacement pressure after low salinity water injection show that low salinity water will cause clay swelling and the absolute value of zeta potential increased. The extreme value of recovery appears in the rocks with a high clay content In neutral and alkaline NaCl solutions, the design of low-salinity water flooding technology in oil fields.As in our previous work, most attempts to study the self-aggregation of methylene blue (MB) in water have been limited to the dimer. In the present work, we have analyzed the self-aggregation of MB in water beyond the dimeric form. For this purpose, the visible light absorption spectra of a large number of aqueous solutions of MB (1.1 × 10-6 to 3.4 × 10-3 M) and NaCl (0.0-0.15 M) at different temperatures (282-333 K) have been fed to a mathematical routine in order to determine the potential existence of a unique higher-order aggregate without any preconception about the aggregation order or about the need of counterions, such as chloride, for compensating the positive charge of the aggregates. Contrary to the common belief that the trimer is the dominant aggregate at high MB concentration, to our surprise we found that the tetramer acting alone, and without any counterion, is the higher-order aggregate that yields the best fitting to all the experimental absorbance spectra, with a very low average relative error of 0.04 ± 0.34%. Also contrary to previous assumptions, it has emerged quite evidently that this aggregate is present in the solution at MB concentrations below 3.4 × 10-5 M (11 ppm), though to a rather low extent. This has brought the need for the recalculation of the visible light absorption spectrum and the thermodynamic parameters for the dimer, which along with those for the tetramer are the main contributions of the present work.A PAA/ZnO/Ag heterostructure composite material was prepared by a reduction method. The properties of composite particles are analyzed by transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), UV-visible spectroscopy, and Raman spectroscopy. Ag nanoparticles play an important role in PAA/ZnO/Ag composite microspheres, conferring new SERS properties and functions to PAA/ZnO/Ag. The intensity of the SERS signal of PAA/ZnO/Ag irradiated with UV light decreased from 10 000 to below 500. Galunisertib TGF-beta inhibitor The SERS detection limit of R6G obtained was reduced to 1 × 10-6 M. The PAA/ZnO/Ag composite particles show a very good degradation effect on R6G under UV light irradiation. This study has developed a new synthesis method to prepare SERS signal enhancement materials with self-cleaning effects. According to the experimental results, the PAA/ZnO/Ag composite material has higher sensitivity than the PAA/ZnO composite material.Modified salinity water (MSW) core flooding tests conducted in carbonates often exhibit a delay in the additional oil recovery. It has been suggested that the ionic adsorption process controls this delay. In this study, we examine the adverse effect of the adsorption process on the performance of MSW flooding in various models categorized as layered and heterogeneous reservoirs and a North Sea field sector model. To evaluate the impact of porous media's heterogeneity on the delay caused by the adsorption, we introduce the net present volumetric value based on which the cost of delay is calculated. This evaluation is achieved by comparing the calculated cost of delay for heterogeneous systems and that of their equivalent homogeneous porous media. It is found that, as the level of reservoir heterogeneity increases, the adverse effect of ionic adsorption on the improved oil production decreases. Further, computational results suggest that the connectivity index, which is defined as the effective permeability between injection and production wells divided by the average permeability, is a better alternative to the vorticity index to describe the impact of the delay of additional oil recovery in heterogeneous reservoirs subjected to MSW flooding.COVID-19 is a biphasic infectious disease with no approved vaccine or pharmacotherapy. The first drug that has shown promise in reducing COVID-19 mortality in severely-ill patients is dexamethasone, a cheap, well-known anti-inflammatory glucocorticoid, approved for the treatment of inflammatory conditions including respiratory diseases such as asthma and tuberculosis. However, about 80% of COVID-19 patients requiring oxygenation, and about 67% of patients on ventilators, are not responsive to dexamethasone therapy mainly. Additionally, using higher doses of dexamethasone for prolonged periods of time can lead to severe side effects and some patients may develop corticosteroid resistance leading to treatment failure. In order to increase the therapeutic efficacy of dexamethasone in COVID-19 patients, while minimizing dexamethasone-related complications that could result from using higher doses of the drug, we applied a chemocentric informatics approach to identify combination therapies. Our results indicated that combining dexamethasone with fast long-acting beta-2 adrenergic agonists (LABAs), such as formoterol and salmeterol, can ease respiratory symptoms hastily, until dexamethasone's anti-inflammatory and immunosuppressant effects kick in.