Enniscochrane6527

05), and ARRs were 0.12 versus 0.30 (p=.05). 45% of Glatopa patients switched (back) to Copaxone 20/40mg and were censored at that point. Mean (SD) all-cause medical and pharmacy costs were $51,507 ($28,494) versus $55,085 ($37,061; p=.50). Mean MS-related costs were $45,379 ($24,732) versus $47,949 ($32,615; p=.67), of which mean disease modifying therapy costs were $42,926 ($23,196) versus $44,932 ($28,554; p=.59). Results were similar in sensitivity analyses.Conclusions In this real-world study, MS patients treated with Glatopa experienced similar health outcomes and costs compared to those treated with Copaxone, with a trend towards lower relapse rates (borderline statistically significant) and cost savings (not statistically significant).Prolonged exposure to aluminum through occupational hazards or food/water intake has been linked to the occurrence of Alzheimer's disease (AD). This study aimed at investigating the neuroprotective effects of Gallic Acid (GA) against aluminum-chloride induced AD in adult Wistar rats. Twenty eight (28) adult Wistar rats were divided into four groups (n = 7). Group A received normal saline as placebo; Group B received 200 mg/kg bw of AlCl3 only; Group C received 100 mg/kg bw of GA only and group D received 100 mg/kg bw of GA and 200 mg/kg bw of AlCl3. At the end of the 60 days experiment, blood samples were collected to obtain serum for analysis and the brain was harvested. Neurobehavioural tests (Morris Water maze, Y-Maze), neurotransmitter levels, oxidative stress markers, serum electrolytes, antioxidant enzymes and histological assessment were carried out. There was a significant decrease in antioxidant enzymes (CAT, GSH and SOD), serum electrolyte (except K+) and neurotransmitter levels (except norepinephrine) with corresponding increase in stress markers (MDA, H2O2 and NO) among group B compared to control but was restored nearly to normal after GA administration. Neurobehavioral tests showed decreased spatial memory impairment and learning deficit in group B compared to control but was ameliorated with GA administration. Histological observation showed neurofibrillary tangles and amyloid plaques in the external granular layer of group B but protected by GA administration. Nutritional supplementation of GA preserve the morphological and physiological integrity of the hippocampus against environmental neurotoxins (AlCl3) by mopping up free radicals associated with oxidative stress induced AD.Background Positive distraction involves distracting oneself from a stressor by thinking about or engaging in activities that induce positive emotion. Wnt activator We hypothesized that although it is a disengagement coping strategy, which have been historically viewed as maladaptive (e.g., avoidance), positive distraction can be an adaptive version that predicts positive outcomes.Design To test this hypothesis, we developed a scale to measure positive and neutral distraction (distracting oneself by engaging in daily activities) in response to chronic stressors in 3 samples (MTurk1, N = 206; undergraduate, N = 376; MTurk2, N = 200). We then correlated the use of these strategies with outcomes in these samples and another undergraduate sample (N = 370).Results Exploratory SEM confirmed that the scale consists of two factors corresponding to positive and neutral distraction, which were positively correlated with avoidance. However, unlike avoidance, positive distraction (and to a lesser degree neutral distraction) was related to positive outcomes such as higher well-being and positive emotions, and fewer depressive symptoms especially when controlling for avoidance.Conclusions Our results suggest that positive distraction can be an adaptive disengagement coping strategy for chronic stressors when controlling for avoidance and should be incorporated into coping studies and interventions.Objective The majority of cases of the fatal neurodegenerative disease amyotrophic lateral sclerosis (ALS) are of unknown etiology. A proportion of these cases are likely to be attributable to contaminant exposures, although the specific environmental etiology of ALS remains largely a mystery. Certain forms of the neurotoxic metal mercury readily cross into the central nervous system. Fish is a dietary source of methylmercury, but also of beneficial components, such as omega-3 polyunsaturated fatty acids. Prior work using clinic-based studies of toenails and hair as keratinous biomarkers of exposure suggest elevated mercury levels in ALS patients compared with controls. We sought to validate this relationship in a U.S. case-control comparison of mercury levels in nail clippings. Methods We performed trace element analysis using inductively coupled plasma mass spectrometry (ICP-MS) on the nail clippings of n = 70 female, geographically representative ALS patients from the National ALS Biorepository and compared them to n = 210 age-matched controls from a set of n = 1216 nationally distributed controls from the Sister and Two Sister Studies. Results Compared to the lowest quartile of nail mercury, moderate levels were associated with decreased risk of ALS (P = 4.18e-6). However, the odds of having nail mercury levels above the 90th percentile were 2.3-fold higher among ALS patients compared with controls (odds ratio (OR) = 2.3, 95% confidence interval 1.10-4.58, adjusted for age and smoking status). Conclusion This finding suggests that excessive mercury exposure may be associated with the neurodegenerative health of aging populations.Background The biopsychosocial model of challenge and threat specifies a challenge-threat continuum where favorable demand-resource evaluations, efficient cardiovascular responses, and superior performance characterize challenge; and maladaptive outcomes like clinical depression characterize threat states. The model also specifies task engagement, operationalized as heart rate and ventricular contractility increases, as a prerequisite for challenge and threat states. The blunted cardiovascular reactivity to stress literature describes reductions of these increases and associates them with problems like clinical depression.Objectives To determine whether blunted cardiovascular reactivity to stress has implications for challenge and threat theory.Methods We review and synthesize the literatures on blunted cardiovascular reactivity to stress and the biopsychosocial model.Results Blunted cardiovascular reactivity appears not to reflect a physiological inability to respond to stress. Rather, it reflects a contextually dependent motivational dysregulation and reduced reactivity to stress consistent with deficient task engagement in the biopsychosocial model.Conclusion We argue that blunted cardiovascular reactivity represents deficient task engagement, and more generally, motivational disengagement due to threat states. Our biopsychosocial model-based approach conceptualizes this motivational disengagement as a tendency to avoid motivated performance situations. This tendency may represent a defense mechanism against subsequent threat and might explain associations with disorders like clinical depression.BACKGROUND There has been an explosion in the use of wearable activity trackers (WATs), but we do not fully understand who wears them and why. This study's purpose was to describe the characteristics of WAT users and to compare current and former users. MATERIALS AND METHODS A variety of internet-based resources (eg, Craigslist, Facebook) were used to recruit current and former WAT users. Respondents completed a web-based survey, where they provided information on sociodemographic characteristics, health, physical activity behavior, and about their WAT use. RESULTS Of the 2826 respondents who gave informed consent, 70.8% (n = 2002) met inclusion criteria for this analysis. Respondents ranged from 18 to 81 years old (mean 32.9 ± 12.2 standard deviation) with 73.8% women. Most were current WAT users (68.7%), and the average length of WAT use overall was 9.3 ± 9.7 months. On average, current users wore the device for 3.7 months longer than former users. Compared to current users, former users had a lower body mass index (1.2 kg/m2 less), reported fewer medical conditions, shared data from their device less often, and received the device as a gift more frequently. CONCLUSIONS Current and former users varied in their reasons for using a WAT and how they used their device. Differences identified between these groups support further exploration of associations between WAT users' profiles and their physical activity behavior.The improved efficiency of cadmium (Cd) phytoextraction potential of Calendula officinalis L. was evaluated in Cd-spiked calcareous soil, using various chelating agents. In a greenhouse study, three chelating agents, including EDTA, citric acid (CA), and tartaric acid (TA), were applied to Cd-spiked soils (50 and 100 mg kg-1) under C. officinalis L. cultivation. According to the results, C. officinalis grew normally without any toxicity signs at various Cd levels of the soil; however, with increasing the Cd levels, the plant dry weight biomass decreased, and activities of antioxidant enzymes (AOEs) increased. The application of CA and TA in Cd-spiked soils improved the physiologic traits of plants and mitigated the Cd stress since the activities of AOEs decreased. Oppositely, due to increasing the Cd excessive permeability to the root of the plant, EDTA application diminished the physiologic traits and increased the activities of AOEs. The results also showed that all the chelators, especially EDTA, markedly increased the Cd mobility factor (from 58.80% to 65.20-89.60%) in Cd-spiked soils. The bioconcentration factor (BCF = 1.3-2.90) and translocation factor (TF = 1.28-1.58) of Cd, which were >1 in all treated and untreated plant samples, as well as the accumulated Cd >100 mg kg-1, demonstrated that C. officinalis is a Cd-hyperaccumulator plant which could remediate Cd by the phytoextraction process. Regarding the biodegradation of CA, as well as the increased TF efficiency of Cd and plant biomass of CA treatments (by decreasing oxidative stress), compared to EDTA and TA treatments, it is recommended that CA be used as a superior chelating agent to enhance the efficiency of Cd phytoremediation in C. officinalis.Unless contraindicated, anticoagulant therapy should be prescribed to elderly patients with atrial fibrillation. Direct-acting oral anticoagulants (DOACs) are superior to vitamin K antagonists for preventing stroke. This, together with their higher net clinical benefit, makes DOACs the treatment of choice in this population. However, due to the concerns about bleeding and the need for dose adjustment based on clinical variables, underdosing of DOACs is common and the risk of stroke high. Drugs with more easily adjusted doses are likely associated with a lower risk of dosing errors and, therefore, a greater protective effect. Correct dosing can ensure a maximal net benefit of DOACs in elderly patients with atrial fibrillation.The study by Shah et al published in this issue of the Journal of Diabetes Science and Technology validates the IDx autonomous diabetic retinopathy (DR) screening program in a real-world setting. The study found high sensitivity (100%) but low specificity (82%) for referable DR. The resulting positive predictive value of 19% means that four out of five patients without referable DR would be referred to ophthalmology causing a significant burden to ophthalmologists, primary care clinics, and patients. Artificial intelligence programs that provide better specificity, multiple levels of DR, and annotations of where lesions are located in the retina may function better than a simple referral/no referral output. This will allow for better engagement of patients through the difficult process of adhering to treatment recommendations and control their diabetes.