Ehlersthomsen6013

Our obtained outstanding results indicated the feasibility of sensing the surface texture for any material in fields such as paper, fashion, apparel manufacturing, and cosmetic industries, which was impossible until now.Falls are among the main causes of injuries in elderly individuals. Balance and mobility impairment are major indicators of fall risk in this group. The objective of this research was to develop a fall risk feedback system that operates in real time using an inertial sensor-based instrumented cane. Based on inertial sensor data, the proposed system estimates the kinematics (contact phase and orientation) of the cane. First, the contact phase of the cane was estimated by a convolutional neural network. Next, various algorithms for the cane orientation estimation were compared and validated using an optical motion capture system. The proposed cane contact phase prediction model achieved higher accuracy than the previous models. In the cane orientation estimation, the Madgwick filter yielded the best results overall. Finally, the proposed system was able to estimate both the contact phase and orientation in real time in a single-board computer.Predicting the activities and properties of materials via in silico methods has been shown to be a cost- and time-effective way of aiding chemists in synthesizing materials with desired properties. Refractive index (n) is one of the most important defining characteristics of an optical material. Presented in this work is a quantitative structure-property relationship (QSPR) model that was developed to predict the refractive index for a diverse set of polymers. A number of models were created, where a four-variable model showed the best predictive performance with R2 = 0.904 and Q2LOO = 0.897. The robustness and predictability of the best model was validated using the leave-one-out technique, external set and y-scrambling methods. The predictive ability of the model was confirmed with the external set, showing the R2ext = 0.880. For the refractive index, the ionization potential, polarizability, 2D and 3D geometrical descriptors were the most influential properties. The developed model was transparent and mechanistically explainable and can be used in the prediction of the refractive index for new and untested polymers.Metformin, a synthetic derivative of guanidine, is commonly used as an oral antidiabetic agent and is considered a multi-vector application agent in the treatment of other inflammatory diseases. Recent studies have confirmed the beneficial effect of metformin on immune cells, with special emphasis on immunological mechanisms. Multiple Sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) characterized by various clinical courses. Although the pathophysiology of MS remains unknown, it is most likely a combination of disturbances of the immune system and biochemical pathways with a disruption of blood-brain barrier (BBB), and it is strictly related to injury of intracerebral blood vessels. Metformin has properties which are greatly desirable for MS therapy, including antioxidant, anti-inflammatory or antiplatelet functions. The latest reports relating to the cardiovascular disease confirm an increased risk of ischemic events in MS patients, which are directly associated with a coagulation cascade and an elevated pro-thrombotic platelet function. Hence, this review examines the potential favourable effects of metformin in the course of MS, its role in preventing inflammation and endothelial dysfunction, as well as its potential antiplatelet role.In the process of rapid drawdown of reservoir water level, the seepage force in the slide mass is an important factor for the stability reduction and deformation increment of many landslides in the reservoir areas. It is feasible to improve the stability of seepage-induced landslide by employing a drainage well to reduce or eliminate the water head difference that generates the seepage force. In this paper, the Shuping landslide, a typical seepage-induced landslide in the Three Gorges Reservoir area of China, is taken as an example. A series of numerical simulations were carried out to figure out the seepage field, and the Morgenstein-Price method was adopted to calculate the landslide stability. Then the influence of horizontal location of the drainage well, drainage well depth, drainage mode on the landslide treatment effect, and the applicability of drainage well were analyzed. The results show that (1) landslide stability increases obviously with the well depth in the slide mass, while the increment of landslide stability with the well depth is limited in the slide bed; (2) the sensitivity of the stability improvement with the depth is greater than that with the horizontal positions of the drainage wells in the slide mass; (3) the drainage well is suggested to be operated when the reservoir water falls rather than operates all the time; and (4) the drainage method is most suitable for landslides with low and medium permeability. These results provide deep insights into the treatment of seepage-induced landslides.Heating temperature is very important in the process of billet production, and it directly affects the quality of billet. CP-456773 However, there is no direct method to measure billet temperature, so we need to accurately predict the temperature of each heating zone in the furnace in order to approximate the billet temperature. link2 Due to the complexity of the heating process, it is difficult to accurately predict the temperature of each heating zone and each heating zone sensor datum to establish a model, which will increase the cost of calculation. To solve these two problems, a two-layer transfer learning framework based on a temporal convolution network (TL-TCN) is proposed for the first time, which transfers the knowledge learned from the source heating zone to the target heating zone. In the first layer, the TCN model is built for the source domain data, and the self-transfer learning method is used to optimize the TCN model to obtain the basic model, which improves the prediction accuracy of the source domain. In the second layer, we propose two frameworks one is to generate the target model directly by using fine-tuning, and the other is to generate the target model by using generative adversarial networks (GAN) for domain adaption. Case studies demonstrated that the proposed TL-TCN framework achieves state-of-the-art prediction results on each dataset, and the prediction errors are significantly reduced. Consistent results applied to each dataset indicate that this framework is the most advanced method to solve the above problem under the condition of limited samples.The automatic sleep stage classification technique can facilitate the diagnosis of sleep disorders and release the medical expert from labor-consumption work. In this paper, novel improved model based essence features (IMBEFs) were proposed combining locality energy (LE) and dual state space models (DSSMs) for automatic sleep stage detection on single-channel electroencephalograph (EEG) signals. Firstly, each EEG epoch is decomposed into low-level sub-bands (LSBs) and high-level sub-bands (HSBs) by wavelet packet decomposition (WPD), separately. Then, the DSSMs are estimated by the LSBs and the LE calculation is carried out on HSBs. Thirdly, the IMBEFs extracted from the DSSM and LE are fed into the appropriate classifier for sleep stage classification. The performance of the proposed method was evaluated on three public sleep databases. The experimental results show that under the Rechtschaffen's and Kale's (R&K) standard, the sleep stage classification accuracies of six classes on the Sleep EDF database and the Dreams Subjects database are 92.04% and 78.92%, respectively. Under the American Academy of Sleep Medicine (AASM) standard, the classification accuracies of five classes in the Dreams Subjects database and the ISRUC database reached 79.90% and 81.65%. The proposed method can be used for reliable sleep stage classification with high accuracy compared with state-of-the-art methods.Traffic emission is one of the major contributors to urban PM2.5, an important environmental health hazard. Estimating roadside PM2.5 concentration increments (above background levels) due to vehicles would assist in understanding pedestrians' actual exposures. This work combines PM2.5 sensing and vehicle detecting to acquire roadside PM2.5 concentration increments due to vehicles. An automatic traffic analysis system (YOLOv3-tiny-3l) was applied to simultaneously detect and track vehicles with deep learning and traditional optical flow techniques, respectively, from governmental cameras that have low resolutions of only 352 × 240 pixels. Evaluation with 20% of the 2439 manually labeled images from 23 cameras showed that this system has 87% and 84% of the precision and recall rates, respectively, for five types of vehicles, namely, sedan, motorcycle, bus, truck, and trailer. By fusing the research-grade observations from PM2.5 sensors installed at two roadside locations with vehicle counts from the nearby governmental cameras analyzed by YOLOv3-tiny-3l, roadside PM2.5 concentration increments due to on-road sedans were estimated to be 0.0027-0.0050 µg/m3. This practical and low-cost method can be further applied in other countries to assess the impacts of vehicles on roadside PM2.5 concentrations.How conditioning intensity is related to outcomes of AML patients undergoing allografting in morphologic remission is an area of great ongoing interest. We studied 743 patients in morphologic remission and known pre-transplant measurable residual disease (MRD) status determined by multiparameter flow cytometry (MFC) who received a first allograft after myeloablative, reduced intensity, or nonmyeloablative conditioning (MAC, RIC, and NMA). Overall, relapse-free survival (RFS) and overall survival (OS) were longer after MAC than RIC or NMA conditioning, whereas relapse risks were not different. Among MRDpos patients, 3-year estimates of relapse risks and survival were similar across conditioning intensities. In contrast, among MRDneg patients, 3-year RFS and OS were longer for MAC (69% and 71%) than RIC (47% and 55%) and NMA conditioning (47% and 52%). Three-year relapse risks were lowest after MAC (18%) and highest after NMA conditioning (30%). Our data indicate an interaction between conditioning intensity, MFC-based pre-transplant MRD status, and outcome, with benefit of intensive conditioning primarily for patients transplanted in MRDneg remission. link3 Differing from recent findings from other studies that indicated MAC is primarily beneficial for some or all patients with MRDpos pre-HCT status, our data suggest MAC should still be considered for MRDneg AML patients if tolerated.Target of rapamycin (TOR) is a serine/threonine kinase that modulates cell growth and metabolism in response to environmental changes. Transfer RNA (tRNA) is an abundant and ubiquitous small non-coding RNA that is essential in the translation of mRNAs. Beyond its canonical role, it has been revealed that tRNAs have more diverse functions. TOR complex 1 (TORC1), which is one of the two TOR complexes, regulates tRNA synthesis by controlling RNA polymerase III. In addition to tRNA synthesis regulation, recent studies have revealed hidden connections between TORC1 and tRNA, which are both essential players in eukaryotic cellular activities. Here, we review the accumulating findings on the regulatory links between TORC1 and tRNA-particularly those links in the budding yeast Saccharomyces cerevisiae and the fission yeast Schizosaccharomyces pombe.