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Moreover, the level of IL-36 was negatively correlated with the level of lung function of patients with COPD, and the levels of IL-36α, IL-36β, and IL-36γ increased with advancing disease severity.

In COPD, the pro-inflammatory effect of IL-36 is closely related to neutrophils, and hence, IL-36 might be considered a novel biomarker for determining COPD severity.

In COPD, the pro-inflammatory effect of IL-36 is closely related to neutrophils, and hence, IL-36 might be considered a novel biomarker for determining COPD severity.Task-based runtime systems are an important branch of parallel programming research, since tasks decouple computation from the compute units, giving the runtime systems greater flexibility than a thread-based solution. This makes it easier to deal with the ever-increasing complexity of parallel architectures by providing a separation of concerns-the specification of parallelism is separated from the implementation of the parallel computations on a specific architecture. The Open Community Runtime is one such system, aimed at large-scale parallel systems. Unlike many other task-based runtime systems, the creators not only provided an implementation but there is also a comprehensive specification document. This has allowed us to create an independent implementation, called OCR-Vx. In this article, we present our experience of developing the runtime system, put our work in the context of the specification and the other implementations, and describe key lessons that we have learned during our work. We discuss the design and implementation issues of task-based runtime systems and applications including task synchronization and scheduling, data management, memory consistency, the relation between shared-memory and distributed-memory runtime systems, NUMA architectures, and heterogeneous systems. The article is aimed at audiences not familiar with OCR, since we believe these lessons could be valuable for developers working on other task-based runtime systems or designing new ones.

In the past few years, the number of studies conducted on the designs of abutments and related materials has increased. The restoration is performed over the implant using prefabricated standard abutments. Due to the problems encountered in relation to bone resorption following restoration, other types of abutment designs have been introduced in the dental field such as molded abutmentsusually fabricated by the lost-wax technique and computer-designed abutments produced by three-dimensional (3D) printing technology. The aim of this study was to compare the clinical performance of molded abutments and computer-designed 3D printed abutments in terms of the bone loss around the implantand the depth of periodontal pockets in a one-year observation period.

The research sample consisted of 32 dental implants for patients who required two adjacent implants. Patients were randomly allocated into two groups in the first group, the patients received molded abutments, whereas, in the second group, the patients receits was within the normal limits. However, the implants that were restored using the printed abutments had less bone resorption than those restored using the molded abutments.

Within the limitations of the current work, the mean bone resorption for both types of abutments was within the normal limits. However, the implants that were restored using the printed abutments had less bone resorption than those restored using the molded abutments.Empagliflozin-induced euglycemic diabetic ketoacidosis is a life-threatening metabolic complication of diabetes mellitus characterized by metabolic acidosis, ketonemia, and relatively normal serum glucose levels. We present a rare case of empagliflozin-induced diabetic ketoacidosis obscured by alkalosis. This case report aims to create awareness among clinicians about this entity and consider this diagnosis in their differential, especially in patients taking sodium-glucose co-transporter (SGLT-2) inhibitors who present to the hospital with unspecific symptoms that may not suggest DKA.Pulmonary embolism (PE) is a potentially lethal condition, although frequently diagnosed, and is rarely associated with transit on initial presentation. Heparin-induced thrombocytopenia (HIT) can cause both arterial thrombus formation and venous thromboembolism. The two forms of HIT must be differentiated in order to guide management. We present a complex and unique case of PE in transit secondary to HIT diagnosed in a patient with a negative serotonin assay.Background Fall from a height is a common cause of trauma requiring emergency care; in many cases, the trauma team needs to urgently develop the initial treatment strategy. selleck The mechanism of injury (intentional or accidental) is an important factor in predicting trauma patterns and severity. We aimed to describe how the severity of injuries in each body region contributes to overall trauma severity and skeletal trauma patterns in intentional and accidental falls. Methods Data accumulated between January 1, 2004 and May 31, 2019 were obtained from a nationwide trauma database. Patients aged ≥18 years and injured by falls from a height were included. The median Abbreviated Injury Scale (AIS) score for the Injury Severity Score (ISS) for each body region (region 1 head, face, and neck; region 2 thorax; region 3 abdomen; region 4 lower extremity and pelvis; and region 5 upper extremity) was investigated. Skeletal injury patterns were classified into four groups group I (intentional/severe), group II (accidental/seurther studies are required to assess the usefulness of our findings for the development of initial treatment strategies at the ED.People are using platforms of social media like Twitter, Facebook, or Instagram as a regular way to reach very much targeted and new prospective customers. The role of online media is to facilitate the opportunity in making a connection with followers and fans every time they log in. Online media keep social posts informative and sometimes entertaining which the followers' glade to see the contents in their feeds. Online media facilitate with low commitment and easy way to prospective consumers for expressing attentiveness in the business you do for your services or product. Online media can offer a number of marketing opportunities for businesses of all dimensions. These opportunities include promotion of the brand, communication to the consumer about service or product, attracting customers, and building strong connections with available consumers. Apart from this, several other benefits can be gained from the business of online media such as the ability to target, broad reach, fast, personal, low cost or free, and easy to use. An overview of the existing approaches, tools, and techniques to present is the dire need of the modern business in order to develop novel ways and to present the business of services or products in an effective and efficient way. Therefore, this study has presented a comprehensive review of the existing literature associated with the techniques, tools, and approaches used for business with the help of online media and to decision making. Based on this study, new mechanisms will be provided for effective business.

It is difficult to distinguish patients with schizophrenia with neuroleptic-induced parkinsonism (NIP) from those with existing idiopathic Parkinson's disease when their striatal dopamine transporter uptake is reduced. There is a possibility of misdiagnosis of Parkinson's disease in patients with schizophrenia as schizophrenia with NIP, which leads to inappropriate treatment. This prospective study aimed at determining the underlying pathophysiology using detailed clinical and psychological assessments.

We enrolled six patients with schizophrenia who had parkinsonism and were diagnosed with Parkinson's disease according to the Movement Disorder Society Clinical Diagnostic Criteria, except for the fifth absolute exclusion criteria.

Five patients had been treated with neuroleptics for 20 years. One patient refused treatment for schizophrenia. All patients had impaired cognitive function at enrolment, olfactory dysfunction, and constipation. All patients were treated with dopaminergic therapy, and their parkinsonism substantially improved; one woman in her 40s experienced a wearing-off effect and dyskinesia. The uptake of dopamine transporter in the striatum decreased by 13%/year during the study period.

Some patients with schizophrenia and parkinsonism benefit from dopaminergic therapy. Some of these patients may also exhibit Lewy pathology.

Some patients with schizophrenia and parkinsonism benefit from dopaminergic therapy. Some of these patients may also exhibit Lewy pathology.Given the effect of the COVID-19 pandemic, which led to the forced adoption of online teaching in several academic institutions across the world, we set out an objective in this paper to examine salient factors that may affect the decision to use online teaching by faculty members (teaching staff). We propose and validate a model based on an extended innovation diffusion theory and 284 online survey responses from Ghana and find that the attitude towards online teaching is predictably influenced by relative advantage and observability. Contrary to theory, complexity boosts rather than inhibits the attitude towards online teaching. The most salient predictors of willingness to use the mode of online teaching are attitude, observability, institutional trust, and compatibility. We conclude with discussions on the important implications for the scientific community and educational policymakers.The present mixed-methods study provides insight into how students in higher education describe and form multiplex relationships in a cohort of students attending a commuter college, thereby improving our understanding of the complex relationships within student groups and their relation to learning. The main aim was to understand the student experience of networking with other students, particularly how commuter students perceive their academic multiplex relationships. Relational data were collected in a cohort of students (n = 109), complemented by 15 semi-structured interviews. One main finding was that students perceived that their largely homophilous multiplex relationships were central to academic achievement, but if students also had limited friendship relations these multiplex relationships could limit students' academic experience. Another finding was how orientation week and group work done during the first semester mainly supported the formation of multiplex networks but were also perceived as barriers by some students. Likewise, commuting both scaffolded network building and became a barrier, especially for students with an immigrant background. One important implication for curriculum development is that faculty cannot leave relationship building to the students alone. A strategic model is discussed that supports emerging multiplex relationships, which can lead to gains in learning, retention, and integration.The rise of mental health problems during COVID-19 has been called a national crisis. Parents and caregivers reported parenting stress, anxiety, and depression, which may be exacerbated by economic insecurity. This study used longitudinal data to examine the association of food insecurity and material social support to subsequent parent and child mental health outcomes in the early weeks of COVID-19. Data were collected from a national convenience sample of U.S. parents (N = 359) at two time points April 14, 2020 (T1) and April 30, 2020 (T2). Data were analyzed using multivariate linear and logistic regression analyses. Most of the sample were mothers (67.5%) and identified as White (69.6%). Among parents for whom services were applicable, over half (51.4%) were unable to receive free and reduced-cost school-based lunch. Food insecurity at T1 was significantly associated with higher odds of parental anxiety (OR = 1.52, p less then .001) and depression (OR = 1.63, p less then .001), as well as increased parenting stress (β = 0.